MOD_CAAXbox
59
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| Functional site class: | CAAX Box |
| Functional site description: | Prenyl groups are attached to a Cys residue 4 residues preceding the C-terminus of certain proteins directed to the plasma membrane |
|---|---|
| ELMs: | MOD_CAAXbox |
| Description: | Generic CAAX box prenylation motif |
| Pattern: | (C)[^DENQ][LIVM].$ (Probability: 0.0000022) |
| Present in taxons: | Eukaryota |
| Interaction Domain: |
PPTA (PF01239) |
|
| Protein prenyltransferases recognise an exposed Cys residue preceding the C-terminus of certain protein substrates. The enzymes covalently attach a prenyl group (farnesyl or geranyl-gernayl) to the Cys residue with the consequence that the (souble) protein is attached to the membrane. Examples of CAAX box proteins include the Ras-like proteins and the G-protein gamma and (some alpha) subunits. |
8 GO-Terms:
Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)