Abstract

Protein prenyltransferases recognise an exposed Cys residue preceding the C-terminus of certain protein substrates. The enzymes covalently attach a prenyl group (farnesyl or geranyl-gernayl) to the Cys residue with the consequence that the (souble) protein is attached to the membrane. Examples of CAAX box proteins include the Ras-like proteins and the G-protein gamma and (some alpha) subunits.

 Selected references

 This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process
protein amino acid prenylation	GO:0018346
protein prenylation	GO:0018342
protein farnesylation	GO:0018343
protein geranylgeranylation	GO:0018344
Cellular Component
cytosol	GO:0005829
Molecular Function
protein prenyltransferase	GO:0008318
protein farnesyltransferase	GO:0004660
protein geranylgeranyltransferase	GO:0004661