The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Accession:
Functional site class:
TRAF6 binding site
Functional site description:
TRAF6 protein acts as intracellular adaptor that is recruited to different receptors through its C-terminal TRAF domain.
ELM Description:
TRAF6 binding site. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmatic tails.
Pattern: ..P.E..[FYWHDE].
Pattern Probability: 0.0017147
Present in taxon: Vertebrata
Interaction Domain:
MATH (PF00917) MATH domain (Stochiometry: 1 : 1)
o See 20 Instances for LIG_TRAF6
o Abstract
TNFR-associated factors (TRAFs) constitute a family of six adaptor proteins that associated with TNF family receptors. Several TRAF proteins interact directly with the intracellular regions of various TNF cytokine receptors, including CD27, CD30, CD40, TNFR2, lymphotoxin beta-receptor, and the Herpes virus entry mediator. The unique biological function of TRAF6 is mainly determinate by its TRAF domain, which does not interact with the peptide motifs that are recognized by the other TRAFs. TRAF6 interacts with the cytoplasmic domain of RANK, CD40 and with interleukin-1 receptor-associated kinase 1 and 2. It was demonstrated that RANK interacts with TRAF6 via a novel interaction motif (Darnay,1999). Ye,2002 solved the crystal structure of TRAF6, alone (1LB4) and in complex with TRAF6-binding peptides from CD40 (1LB6) and RANK (1LB5). The crystal structure of the peptide-TRAF6 interaction revealed a TRAF6-binding motif, present also in three adaptor kinases for IL-1R/TLR signaling.
o 3 selected references:

o 3 GO-Terms:

o 20 Instances for LIG_TRAF6
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P10221 UL37
V120_HHV11
1097 1105 GAPHSNTPVEDDEMIPEDTV TP 3 Herpes simplex virus (type 1 / strain 17)
1 
O43187 IRAK2
IRAK2_HUMAN
524 532 TGSSSNTPEETDDVDNSSLD TP 1 Homo sapiens (Human)
O35305 Tnfrsf11a
TNR11_MOUSE
371 379 SIPPFQEPLEVGENDSLSQC TP 1 Mus musculus (House mouse)
O35305 Tnfrsf11a
TNR11_MOUSE
338 346 GDLSRKIPTEDEYTDRPSQP TP 1 Mus musculus (House mouse)
P25942 CD40
TNR5_HUMAN
231 239 APHPKQEPQEINFPDDLPGS TP 1 Homo sapiens (Human)
O35305 Tnfrsf11a
TNR11_MOUSE
445 453 YTGSGNTPGEDHEPFPGSLK TP 1 Mus musculus (House mouse)
P27512 Cd40
TNR5_MOUSE
235 243 PAARRQDPQEMEDYPGHNTA TP 2 Mus musculus (House mouse)
Q9Y6Q6 TNFRSF11A
TNR11_HUMAN
342 350 EDSFRQMPTEDEYMDRPSQP TP 1 Homo sapiens (Human)
O43187 IRAK2
IRAK2_HUMAN
555 563 GAATPLLPTENGEGRLRVIV TP 1 Homo sapiens (Human)
Q9Y6Q6 TNFRSF11A
TNR11_HUMAN
375 383 STPPFSEPLEVGENDSLSQC TP 1 Homo sapiens (Human)
Q9Y6Q6 TNFRSF11A
TNR11_HUMAN
451 459 CTGCRNPPGEDCEPLVGSPK TP 1 Homo sapiens (Human)
P51617 IRAK1
IRAK1_HUMAN
540 548 ASCIPPSPQENSYVSSTGRA TP 1 Homo sapiens (Human)
P51617 IRAK1
IRAK1_HUMAN
583 591 LQRGPNQPVESDESLGGLSA TP 1 Homo sapiens (Human)
P51617 IRAK1
IRAK1_HUMAN
702 710 PGLGLEQDRQGPEESDEFQS TP 1 Homo sapiens (Human)
Q62406 Irak1
IRAK1_MOUSE
537 545 AGHGSPSPQENSYMSTTGSA TP 1 Mus musculus (House mouse)
Q62406 Irak1
IRAK1_MOUSE
580 588 LQRSPNQPVESDESVPGLSA TP 1 Mus musculus (House mouse)
Q62406 Irak1
IRAK1_MOUSE
700 708 GLDLEPEKSQGPEESDEFQS TP 1 Mus musculus (House mouse)
O43353 RIPK2
RIPK2_HUMAN
192 200 GGTIIYMPPENYEPGQKSRA TP 1 Homo sapiens (Human)
O35305 Tnfrsf11a
TNR11_MOUSE
72 80 SVCLPCGPDEYLDTWNEEDK FP 1 Mus musculus (House mouse)
Q9Y6Q6 TNFRSF11A
TNR11_HUMAN
71 79 SVCLPCGPDEYLDSWNEEDK FP 1 Homo sapiens (Human)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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