The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Accession:
Functional site class:
PCSK cleavage site
Functional site description:
The subtilisin-like proprotein convertases are expressed extensively in mammalian neural and endocrine cells and play a major role in the proteolytic processing of both neuropeptide and peptide hormone precursors.
ELMs with same func. site: CLV_PCSK_FUR_1  CLV_PCSK_KEX2_1  CLV_PCSK_PC1ET2_1  CLV_PCSK_PC7_1  CLV_PCSK_SKI1_1 
ELM Description:
Furin (PACE) cleavage site (R-X-[RK]-R-|-X).
Pattern: R.[RK]R.
Pattern Probability: 0.0005087
Present in taxon: Vertebrata
Interaction Domain:
Peptidase_S8 (PF00082) Subtilase family (Stochiometry: 1 : 1)
o See 13 Instances for CLV_PCSK_FUR_1
o Abstract
The members of the subtilisin-like family are proprotein convertases that process latent precursor proteins into their biologically active products. The prohormone-processing yeast KEX2 protease can act as an intracellular membrane protein or a soluble, secreted endopeptidase. The protein is required for processing of precursors of alpha-factor and killer toxin. PCSK1 (proprotein convertase 1, NEC1) and PCSK2 (proprotein convertase 2, NEC2) are type I proinsulin-processing enzymes that play a key role in regulating insulin biosynthesis. They are also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. PACE4 (paired basic amino acid cleaving system 4, SPC4) is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Its substrates include transforming growth factor beta-related proteins, proalbumin, and von Willebrand factor. Furin (PACE, paired basic amino acid cleaving enzyme, membrane associated receptor protein) is serine endoprotease responsible for processing a variety of substrates (proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor). PC7 (proprotein convertase subtilisin/kexin type 7) is closely related to PACE and PACE4. This calcium-dependent serine endoprotease is concentrated in the trans-Golgi network, associated with membranes, and is not secreted. It can process proalbumin. PC7 and furin are also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140.
o 4 selected references:

o 5 GO-Terms:

o 13 Instances for CLV_PCSK_FUR_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P13497 BMP1
BMP1_HUMAN
117 121 GRWRGRSRSRRAATSRPERV TP 3 Homo sapiens (Human)
Q05320 GP
VGP_EBOZM
498 502 GLITGGRRTRREAIVNAQPK TP 4 Ebola virus - Mayinga, Zaire, 1976
1 
P60170 GP
VSGP_EBOZM
321 325 EPKTSVVRVRRELLPTQGPT TP 3 Ebola virus - Mayinga, Zaire, 1976
P03107 L2
VL2_HPV16
9 13 RHKRSAKRTKRASATQLYKT TP 1 Human papillomavirus type 16
1 
P11223 S
SPIKE_IBVB
534 538 KITNGTRRFRRSITENVANC TP 2 Avian infectious bronchitis virus (strain Beaudette)
P11223 S
SPIKE_IBVB
687 691 LLTNPSSRRKRSLIEDLLFT TP 2 Avian infectious bronchitis virus (strain Beaudette)
P27909 
POLG_DEN1B
202 206 SQTGEHRRDKRSVALAPHVG TP 3 Dengue virus 1 Brazil/97-11/1997
1 
P03188 gB
GB_EBVB9
429 433 TPAAVLRRRRRDAGNATTPV TP 1 Human herpesvirus 4 (strain B95-8) (Epstein-Barr virus (strain B95-8))
P03420 F
FUS_HRSVA
133 137 NVTLSKKRKRRFLGFLLGVG TP 3 Human respiratory syncytial virus A2
1 
P04578 env
ENV_HV1H2
508 512 AKRRVVQREKRAVGIGALFL TP 2 HIV-1 M:B_HXB2R
2 
P03375 env
ENV_HV1B1
508 512 AKRRVVQREKRAVGIGALFL TP 3 Human immunodeficiency virus type 1 BH10
1 
P03383 env
ENV_HTLV2
305 309 PVPPPATRRRRAVPIAVWLV TP 3 Human T-lymphotropic virus 2
1 
O56861 env
ENV_FFV
124 128 GNTSSSSRRRRDIQYHKLPV TP 4 Feline foamy virus
1 
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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