The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
COP1 binding motif
Functional site description:
Motif found in plant photomorphogenesis regulators and in mammalian transcription factors.
ELM Description:
The Constitutive photomorphogenesis protein COP1 was first identified by plant genetics to be involved in light-controlled development. COP1 is a ring finger protein and has now been shown to have ubiquitin ligase activity in both the plant and mammalian context. Proteins controlled by plant COP1 include PIF3, HY5 and LAF1. In animals COP1 has been shown to regulate destruction of p53 and interact with Jun/AP-1.
Pattern: [DE][DE].{2,3}VP[DE]
Pattern Probability: 0.0000231
Present in taxons: Arabidopsis thaliana Homo sapiens Metazoa Viridiplantae
Interaction Domain:
WD40 (PF00400) WD domain, G-beta repeat (Stochiometry: 1 : 1)
o See 7 Instances for DEG_COP1
o Abstract
COP1 is a negative regulator of photomorphogenic development in Arabidopsis thaliana. It cooperates with COP9 signalosome promoting degradation of positive regulators like HY5. Mammalian homologues were identified. Recently the human ortholog, huCOP1, was characterised and it has been shown that interacts with members of JUN family, namely c-jun and junD. All COP1 interacting partners share a conserved motif consisting of a short stretch of negatively charged residues followed by the sequence VP[DE]. It has been demostrated that COP1 recognised the motif via its WD40 repeats domain. Human COP1 seems to regulate AP-1 transcription activity. Relationship between huCOP1 and CSN signalosome (implicated in modulation of AP-1-dependent transcription) has to be tested.
o 6 selected references:

o 4 GO-Terms:

o 7 Instances for DEG_COP1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P41161 ETV5
66 72 EAQVPDDEQFVPDFQSDNLV TP 1 Homo sapiens (Human)
P43268 ETV4
74 80 AQVPDSDEQFVPDFHSENLA TP 1 Homo sapiens (Human)
P50549 ETV1
67 73 AQVPDNDEQFVPDYQAESLA TP 4 Homo sapiens (Human)
229 236 QRLEYRYDDEEEHFLVPDLG TP 1 Arabidopsis thaliana (Thale cress)
P17535 JUND
241 248 RLAALKDEPQTVPDVPSFGE TP 1 Homo sapiens (Human)
O24646 HY5
38 45 EGIESDEEIRRVPEFGGEAV TP 1 Arabidopsis thaliana (Thale cress)
P05412 JUN
227 234 RLQALKEEPQTVPEMPGETP TP 1 Homo sapiens (Human)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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