The Eukaryote Linear Motif resource for Functional Sites in Proteins
LIG_PCNA 140
 
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Functional site class: PCNA binding site
Functional site description: The PCNA binding site is found in proteins involved in DNA replication, repair, methylation and cell cycle control.
ELMs: LIG_PCNA
Description: The PCNA binding site is found in proteins involved in DNA replication, repair and cell cycle control.
Pattern: ((^.{0,3})|(Q)).[^FHWY][ILM][^P][^FHILVWYP][DHFM][FMY].. (Probability: 0.0000041)
Present in taxons: cellular organisms Eukaryota
PDB Structure: 2OD8
PDB:2OD8
Interaction Domain:

PCNA_C (PF02747)
Proliferating cell nuclear antigen, C-terminal domain
(Stochiometry: 1 : 1)

o See 19 Instances for LIG_PCNA


o Abstract

The PCNA binding site is a short motif that mediates interaction with PCNA (Proliferating Cell Nuclear Antigen), the "clamp" that associates proteins with the DNA replication fork. Among such proteins are enzymes involved in DNA replication, DNA repair and DNA methylation. Some proteins involved in cell cycle control also have PCNA binding sites. The site forms a short alpha helix which interacts with a patch on the outer surface of the clamp.

o 1 selected reference:

o 7 GO-Terms:

o 19 Instances for LIG_PCNA
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
DPOD3_YEAST 338 347 SNKRLKKQGTLESFFKRKAK true positive --- Saccharomyces cerevisiae (Baker's yeast)
RAD2_YEAST 995 1004 KKKGKQKRINEFFPREYISG true positive --- Saccharomyces cerevisiae (Baker's yeast)
FEN1_HUMAN 337 346 RQGSTQGRLDDFFKVTGSLS true positive 1U7B
 Homo sapiens (Human)
MSH6_YEAST 27 36 QKKMKQSSLLSFFSKQVPSG true positive --- Saccharomyces cerevisiae (Baker's yeast)
MSH3_YEAST 4 13 MAGQPTISRFFKKAVKSELT true positive --- Saccharomyces cerevisiae (Baker's yeast)
FEN1_YEAST 340 349 LKSGIQGRLDGFFQVVPKTK true positive --- Saccharomyces cerevisiae (Baker's yeast)
DNLI1_HUMAN 2 11 MQRSIMSFFHPKKEGKAKKP true positive --- Homo sapiens (Human)
RFC1_YEAST 1 10 MVNISDFFGKNKKSVRSSTS true positive --- Saccharomyces cerevisiae (Baker's yeast)
DNMT1_HUMAN 164 173 RKSTRQTTITSHFAKGPAKR true positive --- Homo sapiens (Human)
UNG_HUMAN 4 13 MIGQKTLYSFFSPSPARKRH true positive --- Homo sapiens (Human)
DPOD3_SCHPO 362 371 KNTAQSKPQQKSIMSFFGKK true positive --- Schizosaccharomyces pombe (Fission yeast)
DNLI1_YEAST 38 47 GKKPKQATLARFFTSMKNKP true positive 2OD8
 Saccharomyces cerevisiae (Baker's yeast)
RRM3_YEAST 35 44 SHAYRQQTLSSFFMGCGKKS true positive --- Saccharomyces cerevisiae (Baker's yeast)
UNG_YEAST 21 30 ARKRKQTTIEDFFGTKKSTN true positive --- Saccharomyces cerevisiae (Baker's yeast)
DPOD3_HUMAN 456 465 TAALGKANRQVSITGFFQRK true positive 1VYJ
 Homo sapiens (Human)
CDN1A_HUMAN 144 153 GRKRRQTSMTDFYHSKRRLI true positive 1AXC
 Homo sapiens (Human)
ERCC5_HUMAN 990 999 DAQQTQLRIDSFFRLAQQEK true positive --- Homo sapiens (Human)
MSH6_HUMAN 4 13 MSRQSTLYSFFPKSPALSDA true positive --- Homo sapiens (Human)
WRN_HUMAN 144 153 GIEGDQWKLLRDFDIKLKNF false positive --- Homo sapiens (Human)