Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001231 | Q15054 POLD3 DPOD3_HUMAN |
456 | 465 | TAALGKANRQVSITGFFQRK | TP |
1U76 1VYJ |
Homo sapiens (Human) | 466 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0065 | isothermal titration calorimetry | in vitro | Bruning,2004 | support | certain | InteractionDetection |
experimental | MI:0114 | x-ray crystallography | in vitro | Bruning,2004 | support | certain | InteractionDetection FeatureDetection |
Interactions
Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
---|---|---|---|---|---|
(P12004) PCNA_HUMAN | PF02747
(PCNA_C)
Proliferating cell nuclear antigen, C-terminal domain |
127 | 254 | 15.6/15.6 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000679:
Phosphorylation of S458 in the PCNA-binding motif of DNA polymerase delta subunit 3 (POLD3) by cAMP subfamily reduces the affinity of binding to the Proliferating cell nuclear antigen (PCNA) and decreases the processivity of the polymerase complex.
Pathways
KEGG: The sequence Q15054 is implicated in the following 5 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement