ELM - instance LIG_PCNA_PIPBox_1 in sequence P39748 at position 337

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI000792	P39748 FEN1 FEN1_HUMAN	337	346	RQGSTQGRLDDFFKVTGSLS	TP	1U7B 1UL1	Homo sapiens (Human)	380

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0065	isothermal titration calorimetry	in vitro	Bruning,2004	support	certain	InteractionDetection
experimental	MI:0107	surface plasmon resonance	in vitro	Watanabe,1987	support	certain	InteractionDetection FeatureDetection
experimental	MI:0107	surface plasmon resonance	in vitro	Wilson,2017	support	certain	InteractionDetection FeatureDetection
experimental	MI:0114	x-ray crystallography	in vitro	Sakurai,2005	support	certain	InteractionDetection FeatureDetection
experimental	MI:0114	x-ray crystallography	in vitro	Bruning,2004	support	certain	InteractionDetection FeatureDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Warbrick,1997	support	likely	FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(P12004) PCNA_HUMAN	PF02747 (PCNA_C) Proliferating cell nuclear antigen, C-terminal domain	127	254	59.9/59.9	[mitab][xml]

Pathways

KEGG: The sequence P39748 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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