The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
WRPW motif
Functional site description:
The WRPW motif mediates co-repressor recruitment.
ELMs with same func. site: LIG_WRPW_1  LIG_WRPW_2 
ELM Description:
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_1 is based on the C-terminus located motifs found in the Hairy and Runt family proteins.
Pattern: [WFY]RP[WFY].{0,7}$
Pattern Probability: 1.333e-07
Present in taxon: Metazoa
Interaction Domain:
WD40 (PF00400) WD domain, G-beta repeat (Stochiometry: 1 : 1)
o See 95 Instances for LIG_WRPW_1
o Abstract
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family, and has been identified in the Hairy family of basic-helix-loop-helix (bHLH) domain-containing proteins and the Runt family proteins (WRPY) (Paroush,1994; Fisher,1996; Grbavec,1996; Courey,2001). In these two protein families, the motif is situated at (or near) the C-terminus. Additional Groucho-binding motifs not restricted to the C-terminus are: FRPW in Huckebein (Drosophila) near the N-terminus (Goldstein,1999), and FKPY in Brinker (Drosophila) (Zhang,2001).
o 5 selected references:

o 7 GO-Terms:

o 95 Instances for LIG_WRPW_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
DPN_DROME dpn 432 435 SSKKFLAGAIEKSSSAWRPW TP 1 Drosophila melanogaster (Fruit fly)
ESM3_DROME HLHm3 221 224 ETASVSSQESGASEPVWRPW TP 1 Drosophila melanogaster (Fruit fly)
ESM5_DROME HLHm5 175 178 EDSQSAASPKPVEETMWRPW TP 1 Drosophila melanogaster (Fruit fly)
ESM7_DROME HLHm7 183 186 ASDNESLLQISSPGQVWRPW TP 1 Drosophila melanogaster (Fruit fly)
ESM8_DROHY E(spl) 180 183 CESPAPSPMPEEGEKLWRPW TP 1 Drosophila hydei
ESM8_DROME E(spl) 176 179 DCDSPAPSPQPMQQPLWRPW TP 1 Drosophila melanogaster (Fruit fly)
ESMB_DROME HLHmbeta 192 195 ACSPAPSEASSTSGPMWRPW TP 1 Drosophila melanogaster (Fruit fly)
ESMC_DROME HLHmgamma 202 205 IDVTKMEDDSEDEENVWRPW TP 1 Drosophila melanogaster (Fruit fly)
ESMD_DROME HLHmdelta 170 173 RSKSPREEDIHHGEEVWRPW TP 1 Drosophila melanogaster (Fruit fly)
HEY2_DANRE hey2 314 324 QSSGSSSKPYRPWGTEVGAF TP 1 Danio rerio (Zebrafish)
HAIR_DROVI h 375 378 LSLVIKKQIKVEEEQPWRPW TP 1 Drosophila virilis
HES1_CHICK HES1 287 290 PASQAGSPIAERREAVWRPW TP 1 Gallus gallus (Chicken)
HES1_MOUSE Hes1 277 282 VSPSSGSSLTSDSMWRPWRN TP 1 Mus musculus (House mouse)
HES1_RAT Hes1 276 281 VSPSSGSSLTADSMWRPWRN TP 1 Rattus norvegicus (Norway rat)
HES2_HUMAN HES2 170 173 SAPVPSPPSPPCGPGLWRPW TP 1 Homo sapiens (Human)
HES2_MOUSE Hes2 154 157 APAPSPPVPPPGSSGLWRPW TP 1 Mus musculus (House mouse)
HES2_RAT Hes2 154 157 APAPSPPVPPPSSLGLWRPW TP 1 Rattus norvegicus (Norway rat)
HES3_RAT Hes3 172 175 PASNCQAENPRPGFRVWRPW TP 1 Rattus norvegicus (Norway rat)
HES5_MOUSE Hes5 164 167 AAAAAVSTSRQPACGLWRPW TP 1 Mus musculus (House mouse)
HES5_RAT Hes5 163 166 KAAASVSTSRQSACGLWRPW TP 1 Rattus norvegicus (Norway rat)
HEY1_CANFA HEY1 294 304 TQAANLGKPYRPWGTEIGAF TP 1 Canis lupus familiaris (Dog)
HEY1_HUMAN Hey1 294 304 TQAANLGKPYRPWGTEIGAF TP 1 Homo sapiens (Human)
HEY1_MOUSE Hey1 289 299 TQAANLGKPYRPWGTEIGAF TP 1 Mus musculus (House mouse)
G5EFQ5_CAEEL rnt-1 298 301 RRNVSITSSNSSSPTIWRPF TP 1 Caenorhabditis elegans
O76296_HELER HeRunt-1 533 536 TVGHLPTVDDSRKEDVWRPY TP 1 Heliocidaris erythrogramma
Q24612_DROPS run 558 561 PAATKLKNSTVQQKTVWRPY TP 1 Drosophila pseudoobscura
Q24709_DROVI run 547 550 PAATKLKNAVVQQKTVWRPY TP 1 Drosophila virilis
Q26628_STRPU Transcription 532 535 TVGHLPTVDDSRKEDVWRPY TP 1 Strongylocentrotus purpuratus (Purple sea urchin)
Q8JFD4_TAKRU frRunx2 460 463 NSPTILNPGGRMDEAVWRPY TP 1 Takifugu rubripes (Torafugu)
Q8MPK8_PACLE run 414 417 SNGTRAGGPSPNDPSVWRPY TP 1 Pacifastacus leniusculus (Signal crayfish)
Q8MPK9_PACLE run 456 459 SNGTRAGGPSPNDPSVWRPY TP 1 Pacifastacus leniusculus (Signal crayfish)
Q8T306_TRICA hairy 246 249 LSLVVRRCEEPTEEKPWRPW TP 1 Tribolium castaneum (Red flour beetle)
Q8T8A9_HALRO HrHesl1 285 292 SYQINEETDSFIWRPWVAAL TP 1 Halocynthia roretzi
Q8UVG3_CHICK Transcription 469 472 SSPTVLNSSGRMDESVWRPY TP 1 Gallus gallus (Chicken)
HE71B_XENLA hes7.1-b 176 180 KTLVDSHFTYQTFKTWRPWV TP 1 Xenopus laevis (African clawed frog)
Q8UWC8_CHICK Transcription 469 472 SSPTVLNSSGRMDESVWRPY TP 1 Gallus gallus (Chicken)
Q90463_DANRE her1 325 328 SQPRTLRRALFHNQPLWRPW TP 1 Danio rerio (Zebrafish)
Q90464_DANRE her2 105 108 PVDSCQITSEIAKHGLWRPW TP 1 Danio rerio (Zebrafish)
Q90465_DANRE her3 226 229 PKDLKVIECCIFKQNYWRPW TP 1 Danio rerio (Zebrafish)
Q90466_DANRE her4.1 149 152 HANSSAKQHTPARSHIWRPW TP 1 Danio rerio (Zebrafish)
Q90467_DANRE her5 202 205 AMTSSPKQPVMLCDPVWRPW TP 1 Danio rerio (Zebrafish)
Q90468_DANRE her6 331 334 PVAVSPGAPSVTSDSVWRPW TP 1 Danio rerio (Zebrafish)
Q90813_CHICK Ch-runtB2 405 408 NSPTNMGTTARLEEAVWRPY TP 1 Gallus gallus (Chicken)
HES4B_XENLA hes4-b 274 277 VSPLGGSTRADSAESVWRPW TP 1 Xenopus laevis (African clawed frog)
Q90Z13_XENLA hes3.3 180 183 SPHSKGPGPLASTKILWRPW TP 1 Xenopus laevis (African clawed frog)
Q90Z14_XENLA ESR1 151 154 VSDSKQSALASNTNKIWRPW TP 1 Xenopus laevis (African clawed frog)
Q91ZK1_RAT Runx3 406 409 NSPTALSTPGRMDEAVWRPY TP 1 Rattus norvegicus (Norway rat)
Q95UA9_DROSI h 334 337 PLSLVIKKQIKEEEQPWRPW TP 1 Drosophila simulans
HES6_HUMAN HES6 221 224 PAALGSLTTAQIARSVWRPW TP 1 Homo sapiens (Human)
Q96PR6_HUMAN OAF1 294 304 TQAANLGKPYRPWGTEIGPF TP 1 Homo sapiens (Human)
HES7_HUMAN HES7 221 225 QDGAPKAPLPPPPAFWRPWP TP 1 Homo sapiens (Human)
Q9D0R0_MOUSE Hey1 289 299 TQAANLGKPYRPWGTEIGAF TP 1 Mus musculus (House mouse)
Q9DD59_DANRE runx3 435 438 NSPTAMSASTRIDESVWRPY TP 1 Danio rerio (Zebrafish)
Q9DEA0_DANRE runx3 421 424 NSPTAMSASTRIDESVWRPY TP 1 Danio rerio (Zebrafish)
Q9DEF2_ORYLA cbfa1 458 461 NSPTVLNPGGRIDEAVWRPY TP 1 Oryzias latipes (Japanese medaka)
Q9DEU7_DANRE her8a 218 221 SPASLPPFFPGVDPSMWRPW TP 1 Danio rerio (Zebrafish)
Q9DEU8_DANRE her8a 218 221 SPASLPPFFPGVDPSMWRPW TP 1 Danio rerio (Zebrafish)
Q9DF41_DANRE her9 288 291 VSPVGVSAGAESNEPVWRPW TP 1 Danio rerio (Zebrafish)
Q9DF72_DANRE her1 325 328 SQPRTLRRALFHNQPLWRPW TP 1 Danio rerio (Zebrafish)
Q9DF73_DANRE her7 200 204 AQPTSRHPEPASQTVWRPWP TP 1 Danio rerio (Zebrafish)
Q9DGB7_DANRE runx3 421 424 NSPTAMSASTRIDESVWRPY TP 1 Danio rerio (Zebrafish)
Q9DGB8_DANRE runx1 448 451 EGSHSSSPTSMSVEAVWRPY TP 1 Danio rerio (Zebrafish)
HEY1_XENLA hey1 284 294 TTPTPSGKPYRPWGTEIGAF TP 1 Xenopus laevis (African clawed frog)
Q9I9K1_DANRE her7 202 206 AQPTSRHPEPASQTVWRPWP TP 1 Danio rerio (Zebrafish)
Q9JHC5_MOUSE Hes3 197 200 PASNCQAESTRPGFRVWRPW TP 1 Mus musculus (House mouse)
Q9N6W6_DROHY HLHmgamma 214 217 VTKMEEVPDSEDEENVWRPW TP 1 Drosophila hydei
Q9N6W7_DROHY HLHmdelta 155 158 QLSLSPQENLDKGEDVWRPW TP 1 Drosophila hydei
Q9N6W8_DROHY HLHmbeta 202 205 PAPSEASTSSNSTGPMWRPW TP 1 Drosophila hydei
Q9NFW8_CUPSA DNA-binding-p 332 335 MMSQSPPVVSPQSKAVWRPF TP 1 Cupiennius salei
Q9PTN8_XENLA hes5.2 155 158 RCNPSKPENGIGRSSLWRPW TP 1 Xenopus laevis (African clawed frog)
Q9PTN9_XENLA hes3.1 135 144 FQVSAGSTKIWRPWQVLSPP TP 1 Xenopus laevis (African clawed frog)
Q9QUM5_MOUSE Hey1 289 299 TQAANLGKPYRPWGTEIGAF TP 1 Mus musculus (House mouse)
HEY2_HUMAN HEY2 327 337 TSSGTNNKPYRPWGTEVGAF TP 1 Homo sapiens (Human)
Q9VJ16_DROME Side 504 507 AQAAAAAAAAGQDESMWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q9VWX7_DROME Her 146 149 ELDHLVASTSKSKPNLWRPW TP 1 Drosophila melanogaster (Fruit fly)
LOZEN_DROME lz 823 826 GVESAREEDVGDLSQVWRPY TP 1 Drosophila melanogaster (Fruit fly)
Q9W621_CYNPY newt HES1 248 251 SQALSPRALSTGPESVWRPW TP 1 Cynops pyrrhogaster (Japanese firebelly newt)
Q9W7B5_XENLA BHLH-WRPW tra 232 236 TLFPPTSSSVNPALVWRPWP TP 1 Xenopus laevis (African clawed frog)
Q9W7B6_XENLA BHLH-WRPW tra 199 203 PSSPPNPHEQPPLYIWRPWP TP 1 Xenopus laevis (African clawed frog)
RUNX1_MOUSE Runx1 448 451 SNSPTNMPPARLEEAVWRPY TP 1 Mus musculus (House mouse)
RUNX1_RAT Runx1 447 450 SNSPTNMPPARLEEAVWRPY TP 1 Rattus norvegicus (Norway rat)
RUNX2_HUMAN RUNX2 518 521 SSPTVLNSSGRMDESVWRPY TP 1 Homo sapiens (Human)
RUNX2_MOUSE Runx2 604 607 SSPTVLNSSGRMDESVWRPY TP 1 Mus musculus (House mouse)
RUNX3_HUMAN RUNX3 412 415 NSPTALSTPGRMDEAVWRPY TP 1 Homo sapiens (Human)
RUNX3_MOUSE Runx3 406 409 NSPTALSTPGRMDEAVWRPY TP 1 Mus musculus (House mouse)
HAIR_DROME h 334 337 PLSLVIKKQIKEEEQPWRPW TP 1 Drosophila melanogaster (Fruit fly)
HES3_MOUSE Hes3 172 175 PASNCQAESTRPGFRVWRPW TP 1 Mus musculus (House mouse)
RUNX1_XENLA runx1 459 462 NSPTNMGSTPRLEEAVWRPY TP 1 Xenopus laevis (African clawed frog)
HE71A_XENLA hes7.1-a 176 180 KTLVDSHFTYQSFKTWRPWV TP 1 Xenopus laevis (African clawed frog)
HES4A_XENLA hes4-a 278 281 VSPLGGSTGADSAESVWRPW TP 1 Xenopus laevis (African clawed frog)
HES1A_XENLA hes1-a 264 267 PSVSPSVMPSVTIDSVWRPW TP 1 Xenopus laevis (African clawed frog)
HES7_MOUSE Hes7 221 225 QDGAPKAPSLPPPAFWRPWP TP 1 Mus musculus (House mouse)
RUNX1_HUMAN RUNX1 450 453 NSPTNMAPSARLEEAVWRPY TP 1 Homo sapiens (Human)
RUNT_DROME run 507 510 ETTTKIKSAAVQQKTVWRPY TP 1 Drosophila melanogaster (Fruit fly)
HES1_HUMAN HES1 275 280 VSPSSGPSLTADSMWRPWRN TP 2 Homo sapiens (Human)
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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