The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
WRPW motif
Functional site description:
The WRPW motif mediates co-repressor recruitment.
ELMs with same func. site: LIG_WRPW_1  LIG_WRPW_2 
ELM Description:
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_1 is based on the C-terminus located motifs found in the Hairy and Runt family proteins.
Pattern: [WFY]RP[WFY].{0,7}$
Pattern Probability: 1.333e-07
Present in taxon: Metazoa
Interaction Domain:
WD40 (PF00400) WD domain, G-beta repeat (Stochiometry: 1 : 1)
o See 95 Instances for LIG_WRPW_1
o Abstract
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family, and has been identified in the Hairy family of basic-helix-loop-helix (bHLH) domain-containing proteins and the Runt family proteins (WRPY) (Paroush,1994; Fisher,1996; Grbavec,1996; Courey,2001). In these two protein families, the motif is situated at (or near) the C-terminus. Additional Groucho-binding motifs not restricted to the C-terminus are: FRPW in Huckebein (Drosophila) near the N-terminus (Goldstein,1999), and FKPY in Brinker (Drosophila) (Zhang,2001).
o 5 selected references:

o 7 GO-Terms:

o 95 Instances for LIG_WRPW_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
Q26263 dpn
DPN_DROME
432 435 SSKKFLAGAIEKSSSAWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q01068 HLHm3
ESM3_DROME
221 224 ETASVSSQESGASEPVWRPW TP 1 Drosophila melanogaster (Fruit fly)
P13096 HLHm5
ESM5_DROME
175 178 EDSQSAASPKPVEETMWRPW TP 1 Drosophila melanogaster (Fruit fly)
P13097 HLHm7
ESM7_DROME
183 186 ASDNESLLQISSPGQVWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q07291 E(spl)
ESM8_DROHY
180 183 CESPAPSPMPEEGEKLWRPW TP 1 Drosophila hydei
P13098 E(spl)
ESM8_DROME
176 179 DCDSPAPSPQPMQQPLWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q01069 HLHmbeta
ESMB_DROME
192 195 ACSPAPSEASSTSGPMWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q01070 HLHmgamma
ESMC_DROME
202 205 IDVTKMEDDSEDEENVWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q01071 HLHmdelta
ESMD_DROME
170 173 RSKSPREEDIHHGEEVWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q9I9L0 hey2
HEY2_DANRE
314 324 QSSGSSSKPYRPWGTEVGAF TP 1 Danio rerio (Zebrafish)
P29303 h
HAIR_DROVI
375 378 LSLVIKKQIKVEEEQPWRPW TP 1 Drosophila virilis
O57337 HES1
HES1_CHICK
287 290 PASQAGSPIAERREAVWRPW TP 1 Gallus gallus (Chicken)
P35428 Hes1
HES1_MOUSE
277 282 VSPSSGSSLTSDSMWRPWRN TP 1 Mus musculus (House mouse)
Q04666 Hes1
HES1_RAT
276 281 VSPSSGSSLTADSMWRPWRN TP 1 Rattus norvegicus (Norway rat)
Q9Y543 HES2
HES2_HUMAN
170 173 SAPVPSPPSPPCGPGLWRPW TP 1 Homo sapiens (Human)
O54792 Hes2
HES2_MOUSE
154 157 APAPSPPVPPPGSSGLWRPW TP 1 Mus musculus (House mouse)
P35429 Hes2
HES2_RAT
154 157 APAPSPPVPPPSSLGLWRPW TP 1 Rattus norvegicus (Norway rat)
Q04667 Hes3
HES3_RAT
172 175 PASNCQAENPRPGFRVWRPW TP 1 Rattus norvegicus (Norway rat)
P70120 Hes5
HES5_MOUSE
164 167 AAAAAVSTSRQPACGLWRPW TP 1 Mus musculus (House mouse)
Q03062 Hes5
HES5_RAT
163 166 KAAASVSTSRQSACGLWRPW TP 1 Rattus norvegicus (Norway rat)
Q9TSZ2 HEY1
HEY1_CANFA
294 304 TQAANLGKPYRPWGTEIGAF TP 1 Canis lupus familiaris (Dog)
Q9Y5J3 Hey1
HEY1_HUMAN
294 304 TQAANLGKPYRPWGTEIGAF TP 1 Homo sapiens (Human)
Q9WV93 Hey1
HEY1_MOUSE
289 299 TQAANLGKPYRPWGTEIGAF TP 1 Mus musculus (House mouse)
G5EFQ5 rnt-1
G5EFQ5_CAEEL
298 301 RRNVSITSSNSSSPTIWRPF TP 1 Caenorhabditis elegans
O76296 HeRunt-1
O76296_HELER
533 536 TVGHLPTVDDSRKEDVWRPY TP 1 Heliocidaris erythrogramma
Q24612 run
Q24612_DROPS
558 561 PAATKLKNSTVQQKTVWRPY TP 1 Drosophila pseudoobscura
Q24709 run
Q24709_DROVI
547 550 PAATKLKNAVVQQKTVWRPY TP 1 Drosophila virilis
Q26628 Transcription
Q26628_STRPU
532 535 TVGHLPTVDDSRKEDVWRPY TP 1 Strongylocentrotus purpuratus (Purple sea urchin)
Q8JFD4 frRunx2
Q8JFD4_TAKRU
460 463 NSPTILNPGGRMDEAVWRPY TP 1 Takifugu rubripes (Torafugu)
Q8MPK8 run
Q8MPK8_PACLE
414 417 SNGTRAGGPSPNDPSVWRPY TP 1 Pacifastacus leniusculus (Signal crayfish)
Q8MPK9 run
Q8MPK9_PACLE
456 459 SNGTRAGGPSPNDPSVWRPY TP 1 Pacifastacus leniusculus (Signal crayfish)
Q8T306 hairy
Q8T306_TRICA
246 249 LSLVVRRCEEPTEEKPWRPW TP 1 Tribolium castaneum (Red flour beetle)
Q8T8A9 HrHesl1
Q8T8A9_HALRO
285 292 SYQINEETDSFIWRPWVAAL TP 1 Halocynthia roretzi
Q8UVG3 Transcription
Q8UVG3_CHICK
469 472 SSPTVLNSSGRMDESVWRPY TP 1 Gallus gallus (Chicken)
Q8UW72 hes7.1-b
HE71B_XENLA
176 180 KTLVDSHFTYQTFKTWRPWV TP 1 Xenopus laevis (African clawed frog)
Q8UWC8 Transcription
Q8UWC8_CHICK
469 472 SSPTVLNSSGRMDESVWRPY TP 1 Gallus gallus (Chicken)
Q90463 her1
Q90463_DANRE
325 328 SQPRTLRRALFHNQPLWRPW TP 1 Danio rerio (Zebrafish)
Q90464 her2
Q90464_DANRE
105 108 PVDSCQITSEIAKHGLWRPW TP 1 Danio rerio (Zebrafish)
Q90465 her3
Q90465_DANRE
226 229 PKDLKVIECCIFKQNYWRPW TP 1 Danio rerio (Zebrafish)
Q90466 her4.1
Q90466_DANRE
149 152 HANSSAKQHTPARSHIWRPW TP 1 Danio rerio (Zebrafish)
Q90467 her5
Q90467_DANRE
202 205 AMTSSPKQPVMLCDPVWRPW TP 1 Danio rerio (Zebrafish)
Q90468 her6
Q90468_DANRE
331 334 PVAVSPGAPSVTSDSVWRPW TP 1 Danio rerio (Zebrafish)
Q90813 Ch-runtB2
Q90813_CHICK
405 408 NSPTNMGTTARLEEAVWRPY TP 1 Gallus gallus (Chicken)
Q90VV1 hes4-b
HES4B_XENLA
274 277 VSPLGGSTRADSAESVWRPW TP 1 Xenopus laevis (African clawed frog)
Q90Z13 hes3.3
Q90Z13_XENLA
180 183 SPHSKGPGPLASTKILWRPW TP 1 Xenopus laevis (African clawed frog)
Q90Z14 ESR1
Q90Z14_XENLA
151 154 VSDSKQSALASNTNKIWRPW TP 1 Xenopus laevis (African clawed frog)
Q91ZK1 Runx3
Q91ZK1_RAT
406 409 NSPTALSTPGRMDEAVWRPY TP 1 Rattus norvegicus (Norway rat)
Q95UA9 h
Q95UA9_DROSI
334 337 PLSLVIKKQIKEEEQPWRPW TP 1 Drosophila simulans
Q96HZ4 HES6
HES6_HUMAN
221 224 PAALGSLTTAQIARSVWRPW TP 1 Homo sapiens (Human)
Q96PR6 OAF1
Q96PR6_HUMAN
294 304 TQAANLGKPYRPWGTEIGPF TP 1 Homo sapiens (Human)
Q9BYE0 HES7
HES7_HUMAN
221 225 QDGAPKAPLPPPPAFWRPWP TP 1 Homo sapiens (Human)
Q9D0R0 Hey1
Q9D0R0_MOUSE
289 299 TQAANLGKPYRPWGTEIGAF TP 1 Mus musculus (House mouse)
Q9DD59 runx3
Q9DD59_DANRE
435 438 NSPTAMSASTRIDESVWRPY TP 1 Danio rerio (Zebrafish)
Q9DEA0 runx3
Q9DEA0_DANRE
421 424 NSPTAMSASTRIDESVWRPY TP 1 Danio rerio (Zebrafish)
Q9DEF2 cbfa1
Q9DEF2_ORYLA
458 461 NSPTVLNPGGRIDEAVWRPY TP 1 Oryzias latipes (Japanese medaka)
Q9DEU7 her8a
Q9DEU7_DANRE
218 221 SPASLPPFFPGVDPSMWRPW TP 1 Danio rerio (Zebrafish)
Q9DEU8 her8a
Q9DEU8_DANRE
218 221 SPASLPPFFPGVDPSMWRPW TP 1 Danio rerio (Zebrafish)
Q9DF41 her9
Q9DF41_DANRE
288 291 VSPVGVSAGAESNEPVWRPW TP 1 Danio rerio (Zebrafish)
Q9DF72 her1
Q9DF72_DANRE
325 328 SQPRTLRRALFHNQPLWRPW TP 1 Danio rerio (Zebrafish)
Q9DF73 her7
Q9DF73_DANRE
200 204 AQPTSRHPEPASQTVWRPWP TP 1 Danio rerio (Zebrafish)
Q9DGB7 runx3
Q9DGB7_DANRE
421 424 NSPTAMSASTRIDESVWRPY TP 1 Danio rerio (Zebrafish)
Q9DGB8 runx1
Q9DGB8_DANRE
448 451 EGSHSSSPTSMSVEAVWRPY TP 1 Danio rerio (Zebrafish)
Q9I8A3 hey1
HEY1_XENLA
284 294 TTPTPSGKPYRPWGTEIGAF TP 1 Xenopus laevis (African clawed frog)
Q9I9K1 her7
Q9I9K1_DANRE
202 206 AQPTSRHPEPASQTVWRPWP TP 1 Danio rerio (Zebrafish)
Q9JHC5 Hes3
Q9JHC5_MOUSE
197 200 PASNCQAESTRPGFRVWRPW TP 1 Mus musculus (House mouse)
Q9N6W6 HLHmgamma
Q9N6W6_DROHY
214 217 VTKMEEVPDSEDEENVWRPW TP 1 Drosophila hydei
Q9N6W7 HLHmdelta
Q9N6W7_DROHY
155 158 QLSLSPQENLDKGEDVWRPW TP 1 Drosophila hydei
Q9N6W8 HLHmbeta
Q9N6W8_DROHY
202 205 PAPSEASTSSNSTGPMWRPW TP 1 Drosophila hydei
Q9NFW8 DNA-binding-p
Q9NFW8_CUPSA
332 335 MMSQSPPVVSPQSKAVWRPF TP 1 Cupiennius salei
Q9PTN8 hes5.2
Q9PTN8_XENLA
155 158 RCNPSKPENGIGRSSLWRPW TP 1 Xenopus laevis (African clawed frog)
Q9PTN9 hes3.1
Q9PTN9_XENLA
135 144 FQVSAGSTKIWRPWQVLSPP TP 1 Xenopus laevis (African clawed frog)
Q9QUM5 Hey1
Q9QUM5_MOUSE
289 299 TQAANLGKPYRPWGTEIGAF TP 1 Mus musculus (House mouse)
Q9UBP5 HEY2
HEY2_HUMAN
327 337 TSSGTNNKPYRPWGTEVGAF TP 1 Homo sapiens (Human)
Q9VJ16 Side
Q9VJ16_DROME
504 507 AQAAAAAAAAGQDESMWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q9VWX7 Her
Q9VWX7_DROME
146 149 ELDHLVASTSKSKPNLWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q9W349 lz
LOZEN_DROME
823 826 GVESAREEDVGDLSQVWRPY TP 1 Drosophila melanogaster (Fruit fly)
Q9W621 newt HES1
Q9W621_CYNPY
248 251 SQALSPRALSTGPESVWRPW TP 1 Cynops pyrrhogaster (Japanese firebelly newt)
Q9W7B5 BHLH-WRPW tra
Q9W7B5_XENLA
232 236 TLFPPTSSSVNPALVWRPWP TP 1 Xenopus laevis (African clawed frog)
Q9W7B6 BHLH-WRPW tra
Q9W7B6_XENLA
199 203 PSSPPNPHEQPPLYIWRPWP TP 1 Xenopus laevis (African clawed frog)
Q03347 Runx1
RUNX1_MOUSE
448 451 SNSPTNMPPARLEEAVWRPY TP 1 Mus musculus (House mouse)
Q63046 Runx1
RUNX1_RAT
447 450 SNSPTNMPPARLEEAVWRPY TP 1 Rattus norvegicus (Norway rat)
Q13950 RUNX2
RUNX2_HUMAN
518 521 SSPTVLNSSGRMDESVWRPY TP 1 Homo sapiens (Human)
Q08775 Runx2
RUNX2_MOUSE
604 607 SSPTVLNSSGRMDESVWRPY TP 1 Mus musculus (House mouse)
Q13761 RUNX3
RUNX3_HUMAN
412 415 NSPTALSTPGRMDEAVWRPY TP 1 Homo sapiens (Human)
Q64131 Runx3
RUNX3_MOUSE
406 409 NSPTALSTPGRMDEAVWRPY TP 1 Mus musculus (House mouse)
P14003 h
HAIR_DROME
334 337 PLSLVIKKQIKEEEQPWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q61657 Hes3
HES3_MOUSE
172 175 PASNCQAESTRPGFRVWRPW TP 1 Mus musculus (House mouse)
Q6PF39 runx1
RUNX1_XENLA
459 462 NSPTNMGSTPRLEEAVWRPY TP 1 Xenopus laevis (African clawed frog)
Q8UW74 hes7.1-a
HE71A_XENLA
176 180 KTLVDSHFTYQSFKTWRPWV TP 1 Xenopus laevis (African clawed frog)
Q90Z12 hes4-a
HES4A_XENLA
278 281 VSPLGGSTGADSAESVWRPW TP 1 Xenopus laevis (African clawed frog)
Q6IRB2 hes1-a
HES1A_XENLA
264 267 PSVSPSVMPSVTIDSVWRPW TP 1 Xenopus laevis (African clawed frog)
Q8BKT2 Hes7
HES7_MOUSE
221 225 QDGAPKAPSLPPPAFWRPWP TP 1 Mus musculus (House mouse)
Q01196 RUNX1
RUNX1_HUMAN
450 453 NSPTNMAPSARLEEAVWRPY TP 1 Homo sapiens (Human)
P22814 run
RUNT_DROME
507 510 ETTTKIKSAAVQQKTVWRPY TP 1 Drosophila melanogaster (Fruit fly)
Q14469 HES1
HES1_HUMAN
275 280 VSPSSGPSLTADSMWRPWRN TP 2 Homo sapiens (Human)
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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