The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Accession:
Functional site class:
WRPW motif
Functional site description:
The WRPW motif mediates co-repressor recruitment.
ELMs with same func. site: LIG_WRPW_1  LIG_WRPW_2 
ELM Description:
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_1 is based on the C-terminus located motifs found in the Hairy and Runt family proteins.
Pattern: [WFY]RP[WFY].{0,7}$
Pattern Probability: 1.333e-07
Present in taxon: Metazoa
Interaction Domain:
WD40 (PF00400) WD domain, G-beta repeat (Stochiometry: 1 : 1)
o See 20 Instances for LIG_WRPW_1
o Abstract
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family, and has been identified in the Hairy family of basic-helix-loop-helix (bHLH) domain-containing proteins and the Runt family proteins (WRPY) (Paroush,1994; Fisher,1996; Grbavec,1996; Courey,2001). In these two protein families, the motif is situated at (or near) the C-terminus. Additional Groucho-binding motifs not restricted to the C-terminus are: FRPW in Huckebein (Drosophila) near the N-terminus (Goldstein,1999), and FKPY in Brinker (Drosophila) (Zhang,2001).
o 5 selected references:

o 7 GO-Terms:

o 20 Instances for LIG_WRPW_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
Q14469 HES1
HES1_HUMAN
275 280 VSPSSGPSLTADSMWRPWRN TP 2 Homo sapiens (Human)
1 
P22814 run
RUNT_DROME
507 510 ETTTKIKSAAVQQKTVWRPY TP 1 Drosophila melanogaster (Fruit fly)
Q13761 RUNX3
RUNX3_HUMAN
412 415 NSPTALSTPGRMDEAVWRPY TP 1 Homo sapiens (Human)
Q13950 RUNX2
RUNX2_HUMAN
518 521 SSPTVLNSSGRMDESVWRPY TP 1 Homo sapiens (Human)
Q01196 RUNX1
RUNX1_HUMAN
450 453 NSPTNMAPSARLEEAVWRPY TP 1 Homo sapiens (Human)
Q9W349 lz
LOZEN_DROME
823 826 GVESAREEDVGDLSQVWRPY TP 1 Drosophila melanogaster (Fruit fly)
Q9UBP5 HEY2
HEY2_HUMAN
327 337 TSSGTNNKPYRPWGTEVGAF TP 1 Homo sapiens (Human)
Q9BYE0 HES7
HES7_HUMAN
221 225 QDGAPKAPLPPPPAFWRPWP TP 1 Homo sapiens (Human)
Q96HZ4 HES6
HES6_HUMAN
221 224 PAALGSLTTAQIARSVWRPW TP 1 Homo sapiens (Human)
Q9Y5J3 Hey1
HEY1_HUMAN
294 304 TQAANLGKPYRPWGTEIGAF TP 1 Homo sapiens (Human)
Q9Y543 HES2
HES2_HUMAN
170 173 SAPVPSPPSPPCGPGLWRPW TP 1 Homo sapiens (Human)
P14003 h
HAIR_DROME
334 337 PLSLVIKKQIKEEEQPWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q01071 HLHmdelta
ESMD_DROME
170 173 RSKSPREEDIHHGEEVWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q01070 HLHmgamma
ESMC_DROME
202 205 IDVTKMEDDSEDEENVWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q01069 HLHmbeta
ESMB_DROME
192 195 ACSPAPSEASSTSGPMWRPW TP 1 Drosophila melanogaster (Fruit fly)
P13098 E(spl)
ESM8_DROME
176 179 DCDSPAPSPQPMQQPLWRPW TP 1 Drosophila melanogaster (Fruit fly)
P13097 HLHm7
ESM7_DROME
183 186 ASDNESLLQISSPGQVWRPW TP 1 Drosophila melanogaster (Fruit fly)
P13096 HLHm5
ESM5_DROME
175 178 EDSQSAASPKPVEETMWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q01068 HLHm3
ESM3_DROME
221 224 ETASVSSQESGASEPVWRPW TP 1 Drosophila melanogaster (Fruit fly)
Q26263 dpn
DPN_DROME
432 435 SSKKFLAGAIEKSSSAWRPW TP 1 Drosophila melanogaster (Fruit fly)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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