ELM - instance LIG_WRPW_1 in sequence Q14469 at position 275

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI000655	Q14469 HES1 HES1_HUMAN	275	280	VSPSSGPSLTADSMWRPWRN	TP	---	Homo sapiens (Human)	280

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Gratton,2003	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Gratton,2003	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000336:

The Transducin-like enhancer protein 1 (TLE1) can recruit a wide range of transcriptional repressors via its WD domain, to which the WRPW motif of Transcription factor HES-1 (HES1) and the EH1 motif of Homeobox protein goosecoid (GSC) can bind using overlapping sites.

Pathways

KEGG: The sequence Q14469 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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