LIG_WRPW_1
ELM server details
ELM
blue dot
Functional site class:
 WRPW motif
Functional site description:
 The WRPW motif mediates co-repressor recruitment
ELM(s): LIG_WRPW_1, LIG_WRPW_2
LIG_WRPW_1 description: The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_1 is based on the C-terminus located motifs found in the Hairy and Runt family proteins.
Pattern: [WFY]RP[WFY].{0,7}$
Present in taxon(s): Metazoa  
Not represented in taxon(s):

o See instances for LIG_WRPW_1


o Abstract

The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family, and has been identified in the Hairy family of basic-helix-loop-helix (bHLH) domain-containing proteins and the Runt family proteins (WRPY) [PMID:8001118, 8649374, 8687460]. In these two protein families, the motif is situated at (or near) the C-terminus. Additional Groucho binding motifs not restricted to the C-terminus are: FRPW in Huckebein (Drosophila) near the N-terminus [PMID:10433905], and FKPY in Brinker (Drosophila) [PMID:11159907].

Recent review: [PMID:11691830].

o Selected references

Courey AJ, Jia S
Transcriptional repression: the long and the short of it.
Genes Dev 2001 Nov 1;15(21) : 2786-96.
PMID: 11691830

Fisher AL, Ohsako S, Caudy M
The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain.
Mol Cell Biol 1996 Jun;16(6) : 2670-7.
PMID: 8649374

Grbavec D, Stifani S
Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif.
Biochem Biophys Res Commun 1996 Jun 25;223(3) : 701-5.
PMID: 8687460

Jennings BH, Pickles LM, Wainwright SM, Roe SM, Pearl LH, Ish-Horowicz D
Molecular Recognition of Transcriptional Repressor Motifs by the WD Domain of the Groucho/TLE Corepressor.
Mol Cell 2006 Jun 9;22(5) : 645-55.
PMID: 16762837

Paroush Z, Finley RL Jr, Kidd T, Wainwright SM, Ingham PW, Brent R, Ish-Horowicz D
Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins.
Cell 1994 Dec 2;79(5) : 805-15.
PMID: 8001118

o This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process
  cell differentiation
  negative regulation of transcription
  regulation of transcription
Cellular Component
  nucleus
Molecular Function
  transcription cofactor
  transcription factor binding
  transcription co-repressor

 

o Instances for LIG_WRPW_1

SequencePositionSubsequence
(Click for evidence information)		PDBGene NameProtein DescriptionOrganism
Q9W7B5_XENLA 232-236 NPALVWRPWP - - BHLH-WRPW transcription factor ESR-4 (Fragment). Xenopus laevis (African clawed frog).
Q9W7B6_XENLA 199-203 PPLYIWRPWP - - BHLH-WRPW transcription factor ESR-5 (Fragment). Xenopus laevis (African clawed frog).
RUNX1_HUMAN 450-453 LEEAVWRPY - Name=RUNX1; Synonyms=AML1, CBFA2; Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit). Homo sapiens (Human).
RUNX1_MOUSE 448-451 LEEAVWRPY - Name=Runx1; Synonyms=Aml1, Cbfa2, Pebp2ab; Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit). Mus musculus (Mouse).
RUNX1_RAT 447-450 LEEAVWRPY - Name=Runx1; Synonyms=Aml1, Cbfa2; Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B). Rattus norvegicus (Rat).
RUNX2_HUMAN 518-521 MDESVWRPY - Name=RUNX2; Synonyms=AML3, CBFA1, OSF2, PEBP2A; Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2). Homo sapiens (Human).
RUNX2_MOUSE 604-607 MDESVWRPY - Name=Runx2; Synonyms=Aml3, Cbfa1, Osf2, Pebp2a; Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2). Mus musculus (Mouse).
RUNX3_HUMAN 412-415 MDEAVWRPY - Name=RUNX3; Synonyms=AML2, CBFA3, PEBP2A3; Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit). Homo sapiens (Human).
RUNX3_MOUSE 406-409 MDEAVWRPY - Name=Runx3; Synonyms=Aml2, Cbfa3, Pebp2a3; Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit). Mus musculus (Mouse).
RUNT_DROME 506-509 QQKTVWRPY - Name=run; ORFNames=CG1849; Segmentation protein Runt. Drosophila melanogaster (Fruit fly).
HAIR_DROME 334-337 EEEQPWRPW - Name=h; ORFNames=CG6494; Protein hairy. Drosophila melanogaster (Fruit fly).
DPN_DROME 432-435 KSSSAWRPW - Name=dpn; ORFNames=CG8704; Protein deadpan. Drosophila melanogaster (Fruit fly).
ESM3_DROME 221-224 ASEPVWRPW - Name=HLHm3; ORFNames=CG8346; Enhancer of split m3 protein (E(spl)m3) (HLH-m3). Drosophila melanogaster (Fruit fly).
ESM5_DROME 175-178 VEETMWRPW - Name=HLHm5; ORFNames=CG6096; Enhancer of split m5 protein (E(spl)m5). Drosophila melanogaster (Fruit fly).
ESM7_DROME 183-186 SPGQVWRPW - Name=HLHm7; ORFNames=CG8361; Enhancer of split m7 protein (E(spl)m7). Drosophila melanogaster (Fruit fly).
ESM8_DROHY 180-183 EGEKLWRPW - Name=E(spl); Synonyms=M8; Enhancer of split m8 protein (E(spl)m8). Drosophila hydei (Fruit fly).
ESM8_DROME 176-179 MQQPLWRPW - Name=E(spl); Synonyms=m8; ORFNames=CG8365; Enhancer of split m8 protein (E(spl)m8). Drosophila melanogaster (Fruit fly).
ESMB_DROME 192-195 TSGPMWRPW - Name=HLHmbeta; ORFNames=CG14548; Enhancer of split mbeta protein (E(spl)mbeta) (HLH-mbeta) (Split locus enhancer protein mA). Drosophila melanogaster (Fruit fly).
ESMC_DROME 202-205 DEENVWRPW - Name=HLHmgamma; ORFNames=CG8333; Enhancer of split mgamma protein (E(spl)mgamma) (Split locus enhancer protein mB). Drosophila melanogaster (Fruit fly).
ESMD_DROME 170-173 HGEEVWRPW - Name=HLHmdelta; ORFNames=CG8328; Enhancer of split mdelta protein (E(spl)mdelta) (HLH-mdelta) (Split locus enhancer protein mC). Drosophila melanogaster (Fruit fly).
HAIR_DROVI 375-378 EEEQPWRPW - Name=h; Protein hairy. Drosophila virilis (Fruit fly).
HES1_CHICK 287-290 RREAVWRPW - Name=HES1; Synonyms=HAIRY1; Transcription factor HES-1 (Hairy and enhancer of split 1) (C-HAIRY1). Gallus gallus (Chicken).
HES1_HUMAN 275-280 TADSMWRPWRN - Name=HES1; Synonyms=HL, HRY; Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog). Homo sapiens (Human).
HES1_MOUSE 277-282 TSDSMWRPWRN - Name=Hes1; Synonyms=Hes-1; Transcription factor HES-1 (Hairy and enhancer of split 1). Mus musculus (Mouse).
HES1_RAT 276-281 TADSMWRPWRN - Name=Hes1; Synonyms=Hes-1, Hl; Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (RHL). Rattus norvegicus (Rat).
HES2_HUMAN 170-173 CGPGLWRPW - Name=HES2; Transcription factor HES-2 (Hairy and enhancer of split 2). Homo sapiens (Human).
HES2_MOUSE 154-157 GSSGLWRPW - Name=Hes2; Transcription factor HES-2 (Hairy and enhancer of split 2). Mus musculus (Mouse).
HES2_RAT 154-157 SSLGLWRPW - Name=Hes2; Synonyms=Hes-2; Transcription factor HES-2 (Hairy and enhancer of split 2). Rattus norvegicus (Rat).
HES3_MOUSE 172-175 PGFRVWRPW - Name=Hes3; Synonyms=Hes-3; Transcription factor HES-3 (Hairy and enhancer of split 3). Mus musculus (Mouse).
HES3_RAT 172-175 PGFRVWRPW - Name=Hes3; Synonyms=Hes-3; Transcription factor HES-3 (Hairy and enhancer of split 3). Rattus norvegicus (Rat).
HES5_MOUSE 164-167 PACGLWRPW - Name=Hes5; Synonyms=Hes-5; Transcription factor HES-5 (Hairy and enhancer of split 5). Mus musculus (Mouse).
HES5_RAT 163-166 SACGLWRPW - Name=Hes5; Synonyms=Hes-5; Transcription factor HES-5 (Hairy and enhancer of split 5). Rattus norvegicus (Rat).
HEY1_CANFA 294-304 NLGKPYRPWGTEIGAF - Name=HEY1; Synonyms=HESR1; Hairy/enhancer-of-split related with YRPW motif protein 1 (Hairy and enhancer of split-related protein 1) (HESR-1). Canis familiaris (Dog).
HEY1_HUMAN 294-304 NLGKPYRPWGTEIGAF - Name=HEY1; Synonyms=CHF2, HERP2, HESR1, HRT1; Hairy/enhancer-of-split related with YRPW motif protein 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (hHRT1) (Cardiovascular helix-loop-helix factor 2) (CHF-2) (HES-related repressor protein 1). Homo sapiens (Human).
HEY1_MOUSE 289-299 NLGKPYRPWGTEIGAF - Name=Hey1; Synonyms=Herp2, Hesr1, Hrt1; Hairy/enhancer-of-split related with YRPW motif protein 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (mHRT1). Mus musculus (Mouse).
O01834_CAEEL 298-301 SSPTIWRPF - Name=rnt-1; Synonyms=run; ORFNames=B0414.2; Runt related protein 1 (Transcription factor RUN) (RNT-1). Caenorhabditis elegans.
O73725_XENLA 459-462 LEEAVWRPY - Name=Xaml; Xaml. Xenopus laevis (African clawed frog).
O76296_HELER 533-536 RKEDVWRPY - Name=HeRunt-1; HeRunt-1. Heliocidaris erythrogramma (Sea urchin).
RUNT_DROME 507-510 QQKTVWRPY - Name=run; ORFNames=CG1849; Segmentation protein Runt. Drosophila melanogaster (Fruit fly).
LOZEN_DROME 826-829 DLSQVWRPY - Name=lz; ORFNames=CG1689; Protein lozenge. Drosophila melanogaster (Fruit fly).
Q24612_DROPS 558-561 QQKTVWRPY - Name=run; Synonyms=Dpse\run; Dpse\run protein. Drosophila pseudoobscura (Fruit fly).
Q24709_DROVI 547-550 QQKTVWRPY - Name=run; Synonyms=Dvir\run; Dvir\run protein. Drosophila virilis (Fruit fly).
Q26628_STRPU 532-535 RKEDVWRPY - - Transcription factor SpRunt-1. Strongylocentrotus purpuratus (Purple sea urchin).
Q8JFD4_FUGRU 460-463 MDEAVWRPY - Name=frRunx2; Synonyms=frRUNX2, runx2; Transcription factor Cbfa1 (FrRunx2/p51) (FrRUNX2) (Transcription factor runx2). Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
Q8MPK8_PACLE 414-417 NDPSVWRPY - Name=run; Runt protein 1b. Pacifastacus leniusculus (Signal crayfish).
Q8MPK9_PACLE 456-459 NDPSVWRPY - Name=run; Runt protein 1a. Pacifastacus leniusculus (Signal crayfish).
RUNT_DROME 504-507 QQKTVWRPY - Name=run; ORFNames=CG1849; Segmentation protein Runt. Drosophila melanogaster (Fruit fly).
Q8NAM2_HUMAN 298-308 NLGKPYRPWGTEIGAF - - CDNA FLJ35118 fis, clone PLACE6007436, highly similar to Homo sapiens hairy and enhancer of split related-1 (HESR-1) mRNA. Homo sapiens (Human).
Q8T306_TRICA 246-249 TEEKPWRPW - Name=hairy; Helix-loop-helix transcription factor. Tribolium castaneum (Red flour beetle).
Q8T8A9_HALRO 285-292 TDSFIWRPWVAAL - Name=HrHesl1; Hairy E(SPL) like bHLH transcription factor. Halocynthia roretzi (Sea squirt).
Q8UVG3_CHICK 469-472 MDESVWRPY - - Transcription factor RUNX2. Gallus gallus (Chicken).
Q8UW72_XENLA 176-180 QTFKTWRPWV - Name=XHR1-B; HES-related 1B. Xenopus laevis (African clawed frog).
Q8UW73_XENLA 176-180 QSFKTWRPWV - Name=XHR1-A'; HES-related 1A'. Xenopus laevis (African clawed frog).
Q8UW74_XENLA 176-180 QSFKTWRPWV - Name=XHR1-A; HES-related 1A. Xenopus laevis (African clawed frog).
Q8UWC8_CHICK 469-472 MDESVWRPY - - Transcription factor RUNX2/CBFA1. Gallus gallus (Chicken).
Q90463_DANRE 325-328 HNQPLWRPW - Name=her1; Synonyms=HER-1; HER-1 protein. Danio rerio (Zebrafish) (Brachydanio rerio).
Q90464_DANRE 105-108 AKHGLWRPW - Name=her2; Synonyms=HER-2; HER-2 protein. Danio rerio (Zebrafish) (Brachydanio rerio).
Q90465_DANRE 226-229 FKQNYWRPW - Name=her3; Synonyms=HER-3; HER-3 protein (Hairy-related 3). Danio rerio (Zebrafish) (Brachydanio rerio).
Q90466_DANRE 149-152 ARSHIWRPW - Name=her4.2; Synonyms=HER-4, MGC173865, her4, her4.1; HER-4 protein (MGC173865 protein). Danio rerio (Zebrafish) (Brachydanio rerio).
Q90467_DANRE 202-205 LCDPVWRPW - Name=her5; Synonyms=her-5; DNA-binding protein. Danio rerio (Zebrafish) (Brachydanio rerio).
Q90468_DANRE 331-334 TSDSVWRPW - Name=her6; Synonyms=HER-6; HER-6 protein. Danio rerio (Zebrafish) (Brachydanio rerio).
Q90813_CHICK 405-408 LEEAVWRPY - - Ch-runtB2. Gallus gallus (Chicken).
Q90VV1_XENLA 274-277 SAESVWRPW - Name=LOC398258; Hairy2b (LOC398258 protein) (Basic helix-loop-helix transcription factor hairy2b). Xenopus laevis (African clawed frog).
Q90Z12_XENLA 278-281 SAESVWRPW - - Hairy2a. Xenopus laevis (African clawed frog).
Q90Z13_XENLA 180-183 STKILWRPW - Name=ESR2; Enhancer of split related 2. Xenopus laevis (African clawed frog).
Q90Z14_XENLA 151-154 NTNKIWRPW - Name=ESR1; Enhancer of split related 1. Xenopus laevis (African clawed frog).
Q91635_XENLA 263-266 TIDSVWRPW - - Hairy1. Xenopus laevis (African clawed frog).
Q91ZK1_RAT 406-409 MDEAVWRPY - Name=Runx3; Runt-related transcription factor 3. Rattus norvegicus (Rat).
HAIR_DROME 334-337 EEEQPWRPW - Name=h; ORFNames=CG6494; Protein hairy. Drosophila melanogaster (Fruit fly).
Q95UA9_DROSI 334-337 EEEQPWRPW - Name=h; Hairy. Drosophila simulans (Fruit fly).
HES6_HUMAN 219-222 AQIARSVWRPW - Name=HES6; Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). Homo sapiens (Human).
HES6_HUMAN 221-224 IARSVWRPW - Name=HES6; Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). Homo sapiens (Human).
Q96PR6_HUMAN 294-304 NLGKPYRPWGTEIGPF - Name=OAF1; Basic helix-loop-helix protein OAF1. Homo sapiens (Human).
HES7_MOUSE 221-225 PPPAFWRPWP - Name=Hes7; Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7). Mus musculus (Mouse).
HES7_HUMAN 221-225 PPPAFWRPWP - Name=HES7; Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7). Homo sapiens (Human).
Q9D0R0_MOUSE 289-299 NLGKPYRPWGTEIGAF - Name=Hey1; 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2600002K17 product:hairy/enhancer-of-split related with YRPW motif 1, full insert sequence. Mus musculus (Mouse).
Q9DD59_DANRE 435-438 IDESVWRPY - Name=runx3; Synonyms=runxb; Runt-related transcription factor b. Danio rerio (Zebrafish) (Brachydanio rerio).
Q9DEA0_DANRE 421-424 IDESVWRPY - Name=runx3; Transcription factor runt-1 (Runx3 transcription factor). Danio rerio (Zebrafish) (Brachydanio rerio).
Q9DEF2_ORYLA 458-461 IDEAVWRPY - Name=cbfa1; Core binding factor alpha1 subunit ptotein. Oryzias latipes (Medaka fish) (Japanese ricefish).
Q9DEU7_DANRE 218-221 VDPSMWRPW - Name=her8a; Synonyms=her-8b, her8b; Transcription factor Her-8b (Her8a protein). Danio rerio (Zebrafish) (Brachydanio rerio).
Q9DEU8_DANRE 218-221 VDPSMWRPW - Name=her8a; Synonyms=her-8a; Transcription factor Her-8a. Danio rerio (Zebrafish) (Brachydanio rerio).
Q9DF41_DANRE 288-291 SNEPVWRPW - Name=her9; BHLH-WRPW transcription factor (Hairy-related 9). Danio rerio (Zebrafish) (Brachydanio rerio).
Q9DF72_DANRE 325-328 HNQPLWRPW - Name=her1; Synonyms=her-1; HER-1 protein. Danio rerio (Zebrafish) (Brachydanio rerio).
Q9DF73_DANRE 200-204 ASQTVWRPWP - Name=her7; Synonyms=her-7; HER-7 protein. Danio rerio (Zebrafish) (Brachydanio rerio).
Q9DGB7_DANRE 421-424 IDESVWRPY - Name=runx3; Synonyms=runxb; Runt-related transcription factor b. Danio rerio (Zebrafish) (Brachydanio rerio).
Q9DGB8_DANRE 448-451 SVEAVWRPY - Name=runx1; Synonyms=runxa; Runt-related transcription factor a (Runx1 transcription factor). Danio rerio (Zebrafish) (Brachydanio rerio).
HEY1_XENLA 284-294 PSGKPYRPWGTEIGAF - Name=hey1; Synonyms=hrt1, xbc8; Hairy/enhancer-of-split related with YRPW motif protein 1 (Hairy- related transcription factor 1) (Protein xHRT-1). Xenopus laevis (African clawed frog).
Q9I9K1_DANRE 202-206 ASQTVWRPWP - Name=her7; Her7-protein. Danio rerio (Zebrafish) (Brachydanio rerio).
HEY2_DANRE 314-324 SNSKPYRPWGTEVGAF - Name=hey2; Synonyms=grl; ORFNames=zgc:136746; Hairy/enhancer-of-split related with YRPW motif protein 2 (Protein gridlock). Danio rerio (Zebrafish) (Brachydanio rerio).
Q9JHC5_MOUSE 197-200 PGFRVWRPW - Name=Hes3; Synonyms=HES-3; Helix-loop-helix transcription factor. Mus musculus (Mouse).
Q9N6W6_DROHY 214-217 DEENVWRPW - Name=HLHmgamma; Synonyms=E(spl)region transcript mgamma, HLHm-gamma; HLHmgamma protein. Drosophila hydei (Fruit fly).
Q9N6W7_DROHY 155-158 KGEDVWRPW - Name=HLHmdelta; Synonyms=E(spl)region transcript mdelta, HLHm-delta; HLHmdelta protein. Drosophila hydei (Fruit fly).
Q9N6W8_DROHY 202-205 STGPMWRPW - Name=HLHmbeta; Synonyms=E(spl)region transcript mbeta, HLHm-beta; HLHmbeta protein. Drosophila hydei (Fruit fly).
Q9NFW8_CUPSA 332-335 QSKAVWRPF - - DNA-binding-protein hairy (Fragment). Cupiennius salei (Wandering spider).
Q9PTN8_XENLA 155-158 GRSSLWRPW - Name=ESR-7; Enhancer of split related protein-7. Xenopus laevis (African clawed frog).
Q9PTN9_XENLA 135-144 GSTKIWRPWQVLSPP - Name=ESR-6e; Enhancer of split related epidermal protein-6. Xenopus laevis (African clawed frog).
Q9QUM5_MOUSE 289-299 NLGKPYRPWGTEIGAF - Name=Hey1; Synonyms=Hrt1; Basic-helix-loop-helix protein (BHLH) (Adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230346O09 product:hairy/enhancer-of-split related with YRPW motif 1, full insert sequence) (Hairy/enhancer-of-split related with YRPW motif 1) (HES- related repressor protein 2 HERP2) (Cardiovascular helix-loop-helix factor 2) (Hairy-related transcription factor 1) (Brain cDNA, clone MNCb-2686, similar to Mus musculus hairy/enhancer-of-split related with YRPW motif1(Hey1), mRNA). Mus musculus (Mouse).
RUNT_DROME 507-510 QQKTVWRPY - Name=run; ORFNames=CG1849; Segmentation protein Runt. Drosophila melanogaster (Fruit fly).
RUNT_DROME 507-510 QQKTVWRPY - Name=run; ORFNames=CG1849; Segmentation protein Runt. Drosophila melanogaster (Fruit fly).
RUNT_DROME 507-510 QQKTVWRPY - Name=run; ORFNames=CG1849; Segmentation protein Runt. Drosophila melanogaster (Fruit fly).
HEY2_HUMAN 327-337 TNNKPYRPWGTEVGAF - Name=HEY2; Synonyms=CHF1, GRL, HERP, HERP1, HRT2; Hairy/enhancer-of-split related with YRPW motif protein 2 (Cardiovascular helix-loop-helix factor 1) (hCHF1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (hHRT2) (HES-related repressor protein 2) (Protein gridlock homolog). Homo sapiens (Human).
Q9VJ16_DROME 504-507 QDESMWRPW - Name=Side; ORFNames=CG10446, Dmel_CG10446; CG10446-PA (GH26014p). Drosophila melanogaster (Fruit fly).
RUNT_DROME 507-510 QQKTVWRPY - Name=run; ORFNames=CG1849; Segmentation protein Runt. Drosophila melanogaster (Fruit fly).
Q9VWX7_DROME 146-149 SKPNLWRPW - Name=Her; ORFNames=Dmel_CG5927; CG5927-PA (IP01491p). Drosophila melanogaster (Fruit fly).
LOZEN_DROME 823-826 DLSQVWRPY - Name=lz; ORFNames=CG1689; Protein lozenge. Drosophila melanogaster (Fruit fly).
Q9W621_CYNPY 248-251 GPESVWRPW - Name=newt HES1; Newt HES1. Cynops pyrrhogaster (Japanese common newt).