 << LIG_MDM2 << |
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| Functional site class: | MYND ligand |
| Functional site description: | The MYND zinc finger found in certain transcription factors and transcriptional cofactors interact with other proteins through the PxLxP motif. |
|---|---|
| ELMs: | LIG_MYND |
| Description: | The MYND finger is a protein domain with a Cys6-His-Cys-motif found in some transcription factors, Suppressin (SPN; a suppressor of cell proliferation), and BS69 and m-Bop, putative transcriptional cofactors. The MYND domain of BS69 has been shown to interact with the viral tumour antigens E1a and ENBA2 as well as with MGA, a Myc-related protein ( 11733528), while the MYND domain of m-Bop binds the transcriptional activator skNAC (12011100). All these interactions involve one or two PXLXP motifs. |
| Pattern: | [^WFHYG][MAPSTLIV]P[^CGW]L[^EDKRPG]P[^WFHYG] (Probability: 0.0001774) |
| Present in taxons: |
Metazoa
|
| Interaction Domain: |
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| The MYND finger is a protein domain with a Cys6-His-Cys-motif found in some transcription factors, Suppressin (SPN; a suppressor of cell proliferation), and BS69 and m-Bop, putative transcriptional cofactors. The MYND domain of BS69 has been shown to interact with the viral tumour antigens E1a and EBNA2 as well as with MGA, a Myc-related protein [ |
3 GO-Terms:
2 Instances for LIG_MYND
(click table headers for sorting)
| Sequence | Start | End | Subsequence | Instance Logic | PDB | Organism |
|---|---|---|---|---|---|---|
 EBNA2_EBVB9 |
381 | 388 | PNTSSPSMPELSPVLGLHQG | true positive | --- |
Human herpesvirus 4 (strain B95-8)
(Epstein-Barr virus (strain B95-8))
|
|
EBNA2_EBVB9 |
435 | 442 | ESHNSPEAPILFPDDWYPPS | true positive | --- |
Human herpesvirus 4 (strain B95-8)
(Epstein-Barr virus (strain B95-8))
|
Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)
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