Accession: | |
---|---|
Functional site class: | Corepressor nuclear receptor box |
Functional site description: | The CORNR box motif is found in coprepressors of nuclear receptors (NRs), and confers binding to NRs |
ELM Description: | The corepressor nuclear receptor box motif confers binding to nuclear receptors. |
Pattern: | L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] |
Pattern Probability: | 0.0000010 |
Present in taxon: | Metazoa |
Interaction Domain: |
Hormone_recep (PF00104)
Ligand-binding domain of nuclear hormone receptor
(Stochiometry: 1 : 1)
PDB Structure: 1KKQ
|
Abstract |
The corepressor nuclear receptor (CORNR) box is found in the N-CoR and SMRT corepressors of nuclear receptors (NRs), and confers binding to NRs. Repression of NR regulated genes is mediated by histone deacetylated which are recruited by the N-CoR and SMRT corepressors. Both N-CoR and SMRT have two copies of the CORNR box. The consensus sequence is LxxxIxxxI/L. A structural analysis of the second CORNR box of SMRT bound to the AF-2 domain of PPARalpha shows the CORNR box is a 9 aa alpha-helix that is bound to the AF-2 domain groove of PPARalpha (Xu,2002), in a similar manner to the related NR box (ELM_ID:LIG_NRBOX) found in co-activators of NRs. However, preference for the CORNR box over the NR box is dictated by the exact conformation of the AF-2 domain. In the unliganded state (or when bound to agonist ligands), the AF-2 domain conformation of the NRs promotes binding of corepressors through the CORNR box. In this state, the NR boxes of coactivators does not fit into the groove (Jepsen,2002). |
6 GO-Terms:
4 Instances for LIG_CORNRBOX
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, Name | Start | End | Subsequence | Logic | #Ev. | Organism | Notes |
---|---|---|---|---|---|---|---|
O75376 NCOR1 NCOR1_HUMAN |
2263 | 2271 | ASNLGLEDIIRKALMGSFDD | TP | 2 | Homo sapiens (Human) | |
O75376 NCOR1 NCOR1_HUMAN |
2051 | 2059 | HRLITLADHICQIITQDFAR | TP | 2 | Homo sapiens (Human) | |
Q9Y618 NCOR2 NCOR2_HUMAN |
2143 | 2151 | QRVVTLAQHISEVITQDYTR | TP | 2 | Homo sapiens (Human) | |
Q9Y618 NCOR2 NCOR2_HUMAN |
2350 | 2358 | STNMGLEAIIRKALMGKYDQ | TP | 2 | Homo sapiens (Human) |
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement