The Eukaryote Linear Motif resource for Functional Sites in Proteins
Functional site class:
Corepressor nuclear receptor box
Functional site description:
The CORNR box motif is found in coprepressors of nuclear receptors (NRs), and confers binding to NRs
ELM Description:
The corepressor nuclear receptor box motif confers binding to nuclear receptors.
Pattern: L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL]
Pattern Probability: 0.0000010
Present in taxon: Metazoa
Interaction Domain:
Hormone_recep (PF00104) Ligand-binding domain of nuclear hormone receptor (Stochiometry: 1 : 1)
PDB Structure: 1KKQ
o See 4 Instances for LIG_CORNRBOX
o Abstract
The corepressor nuclear receptor (CORNR) box is found in the N-CoR and SMRT corepressors of nuclear receptors (NRs), and confers binding to NRs. Repression of NR regulated genes is mediated by histone deacetylated which are recruited by the N-CoR and SMRT corepressors. Both N-CoR and SMRT have two copies of the CORNR box. The consensus sequence is LxxxIxxxI/L. A structural analysis of the second CORNR box of SMRT bound to the AF-2 domain of PPARalpha shows the CORNR box is a 9 aa alpha-helix that is bound to the AF-2 domain groove of PPARalpha (Xu,2002), in a similar manner to the related NR box (ELM_ID:LIG_NRBOX) found in co-activators of NRs. However, preference for the CORNR box over the NR box is dictated by the exact conformation of the AF-2 domain. In the unliganded state (or when bound to agonist ligands), the AF-2 domain conformation of the NRs promotes binding of corepressors through the CORNR box. In this state, the NR boxes of coactivators does not fit into the groove (Jepsen,2002).
o 2 selected references:

o 6 GO-Terms:

o 4 Instances for LIG_CORNRBOX
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
O75376 NCOR1
2051 2059 HRLITLADHICQIITQDFAR TP 2 Homo sapiens (Human)
Q9Y618 NCOR2
2143 2151 QRVVTLAQHISEVITQDYTR TP 2 Homo sapiens (Human)
Q9Y618 NCOR2
2350 2358 STNMGLEAIIRKALMGKYDQ TP 2 Homo sapiens (Human)
O75376 NCOR1
2263 2271 ASNLGLEDIIRKALMGSFDD TP 2 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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