LIG_MYND
ELM server details
ELM
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Functional site class:
 MYND ligand
Functional site description:
 The MYND zinc finger found in certain transcription factors and transcriptional cofactors interact with other proteins through the PxLxP motif.
ELM(s): LIG_MYND
LIG_MYND description: The MYND finger is a protein domain with a Cys6-His-Cys-motif found in some transcription factors, Suppressin (SPN; a suppressor of cell proliferation), and BS69 and m-Bop, putative transcriptional cofactors. The MYND domain of BS69 has been shown to interact with the viral tumour antigens E1a and ENBA2 as well as with MGA, a Myc-related protein [PMID: 11733528], while the MYND domain of m-Bop binds the transcriptional activator skNAC [PMID: 12011100]. All these interactions involve one or two PXLXP motifs.
Pattern: [^WFHYG][MAPSTLIV]P[^CGW]L[^EDKRPG]P[^WFHYG]
Present in taxon(s): Metazoa  
Not represented in taxon(s):

o Abstract

The MYND finger is a protein domain with a Cys6-His-Cys-motif found in some transcription factors, Suppressin (SPN; a suppressor of cell proliferation), and BS69 and m-Bop, putative transcriptional cofactors. The MYND domain of BS69 has been shown to interact with the viral tumour antigens E1a and ENBA2 as well as with MGA, a Myc-related protein [PMID: 11733528], while the MYND domain of m-Bop binds the transcriptional activator skNAC [PMID: 12011100]. All these interactions involve one or two PXLXP motifs.

o Selected references

o This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process
  transcription
Cellular Component
  nucleus
Molecular Function
  transcription factor binding

 

o Instances for LIG_MYND

No instances annotated