 Abstract
The corepressor nuclear receptor (CORNR) box is found in the N-CoR and SMRT corepressors of nuclear receptors (NRs), and confers binding to NRs. Repression of NR regulated genes is mediated by histone deacetylated which are recruited by the N-CoR and SMRT corepressors.
Both N-CoR and SMRT have two copies of the CORNR box. The consensus sequence is LXXXIXXXI/L. A structural analysis of the second CORNR box of SMRT bound to the AF-2 domain of PPARalpha shows the CORNR box is a 9 aa alpha-helix that is bound to the AF-2 domain groove of PPARalpha (PMID:11845213), in a similar manner to the related NR box (ELM_ID:LIG_NRBOX) found in co-activators of NRs. However, preference for the CORNR box over the NR box is dictated by the exact conformation of the AF-2 domain. In the unliganded state (or when bound to agonist ligands), the AF-2 domain conformation of the NRs promotes binding of corepressors through the CORNR box. In this state, the NR boxes of coactivators does not fit into the groove.
Recent review: PMID: 11865025.
Selected references
| Jepsen K, Rosenfeld MG | | Biological roles and mechanistic actions of co-repressor complexes. | | J Cell Sci 2002 Feb 15;115() : 689-98. | | PMID: 11865025 |
| Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, Cobb JE, McKee DD, Galardi CM, Plunket KD, Nolte RT, Parks DJ, Moore JT, Kliewer SA, Willson TM, Stimmel JB | | Structural basis for antagonist-mediated recruitment of nuclear
co-repressors by PPARalpha. | | Nature 2002 Feb 14;415(6873) : 813-7. | | PMID: 11845213 |
This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.
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Biological Process |
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regulation of transcription
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negative regulation of transcription
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Cellular Component |
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nucleus |
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Molecular Function |
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transcription co-repressor |
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transcription factor binding |
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transcription cofactor |
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