The Eukaryote Linear Motif resource for Functional Sites in Proteins
Functional site class:
WRPW motif
Functional site description:
The WRPW motif mediates co-repressor recruitment.
ELMs with this model: LIG_WRPW_1  LIG_WRPW_2 
Description:
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_2 is not restricted to the C-terminus (in contrast to LIG_WRPW_1).
Pattern: [WFY][KR]P[WFY]
Pattern Probability: 0.0000182
Present in taxon: Eumetazoa
Interaction Domain:
WD40 (PF00400) WD domain, G-beta repeat (Stochiometry: 1 : 1)
o Abstract
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family, and has been identified in the Hairy family of basic-helix-loop-helix (bHLH) domain-containing proteins and the Runt family proteins (WRPY) (Paroush,1994; Fisher,1996; Grbavec,1996; Courey,2001). In these two protein families, the motif is situated at (or near) the C-terminus. Additional Groucho-binding motifs not restricted to the C-terminus are: FRPW in Huckebein (Drosophila) near the N-terminus (Goldstein,1999), and FKPY in Brinker (Drosophila) (Zhang,2001).
o 2 selected references:

o 3 GO-Terms:

o No Instance for LIG_WRPW_2
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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