Accession: | |
---|---|
Functional site class: | SID |
Functional site description: | Sin3 interacting domain |
ELMs with same func. site: | LIG_Sin3_1 LIG_Sin3_2 LIG_Sin3_3 |
ELM Description: | Motif interacts with PAH2 domain in the Sin3 scaffold protein. |
Pattern: | [LIV]..[LM]L.AA.[FY][LI] |
Pattern Probability: | 1.759e-08 |
Present in taxon: | Eukaryota |
Interaction Domain: |
PAH (PF02671)
Paired amphipathic helix repeat
(Stochiometry: 1 : 1)
PDB Structure: 1PD7
|
Abstract |
Gene-specific targeting of the Sin3 co-repressor complex by DNA-bound repressors is an important mechanism of gene silencing in eukaryotes. The Sin3 co-repressor is a scaffold protein able to interact with several proteins simultaneously. Sin3 specifically interacts with a diverse set of transcriptional repressors, the first of which were identified as the MAD-family members. Sin3 contains paired amphipatic helix repeat domains (PAH) that mediate protein-protein interactions. In addition, Sin3 has a histone deacetylase binding site. The SID (Sin3 interacting domain) motif specifically interacts with the PAH2 domain in Sin3. In humans, the Sin3 protein has two splice isoforms: mSin3A and mSinB. Both have the PAH2 domain and can interact with a SID-containing protein. The structure of the PAH2:MAD1 interaction has been solved (1G1E) (Brubaker,2000). The SID helix is an amphiphatic alpha helix that engages in substantial hydrophobic interactions with a deep hydrophobic groove defined by two PAH2 helices. Presumably all SID-containing proteins are targeted to a DNA region either by direct DNA binding or interaction with a DNA-binding partner, and recruit the Sin3-complex, which ultimately leads to deacetylation and repression of transcription. |
4 GO-Terms:
4 Instances for LIG_Sin3_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, Name | Start | End | Subsequence | Logic | #Ev. | Organism | Notes |
---|---|---|---|---|---|---|---|
Q99583 MNT MNT_HUMAN |
3 | 13 | MSIETLLEAARFLEWQAQQQ | TP | 1 | Homo sapiens (Human) | |
P50539 MXI1 MXI1_HUMAN |
9 | 19 | KMINVQRLLEAAEFLERRER | TP | 1 | Homo sapiens (Human) | |
Q14582 MXD4 MAD4_HUMAN |
6 | 16 | ELNSLLILLEAAEYLERRDR | TP | 3 | Homo sapiens (Human) | |
Q05195 MXD1 MAD1_HUMAN |
9 | 19 | VRMNIQMLLEAADYLERRER | TP | 2 | Homo sapiens (Human) |
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement