Accession: | |
---|---|
Functional site class: | HP1 ligand |
Functional site description: | Motif in proteins that interact with the chromoshadow domain of Heterochromatin-binding protein 1. |
ELM Description: | Motif is a ligand to an interface formed by dimerization of two chromoshadow domains in HP1 proteins. |
Pattern: | P[MVLIRWY]V[MVLIAS][LM] |
Pattern Probability: | 0.0000338 |
Present in taxon: | Eukaryota |
Interaction Domain: |
Chromo_shadow (PF01393)
Chromo shadow domain
(Stochiometry: 1 : 1)
PDB Structure: 1S4Z
|
Abstract |
HP1 is a nonhistone chromosomal protein primarily associated with heterochromatin. In mammals three variants exist: HP1 alpha, HP1 beta and HP1 gamma. All have an N-terminal chromodomain (SM00298) and a C-terminal chromoshadow domain (SM00300). The HP1 chromodomain can bind to metylated lysine 9 on histone H3, while the chromoshadow domain can mediate homo-dimerisation and interaction with other proteins. The PxVxL motif was identified as a HP1-binding motif by Smothers,2000). Several chromatin modifying proteins have been shown to interact with HP1 using this motif. Structural analysis has shown that the motif interacts with a chomoshadow domain dimer (Brasher,2000). |
5 GO-Terms:
9 Instances for LIG_HP1_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, Name | Start | End | Subsequence | Logic | #Ev. | Organism | Notes |
---|---|---|---|---|---|---|---|
Q62318 Trim28 TIF1B_MOUSE |
486 | 490 | SGLLRKVPRVSLERLDLDLT | TP | 4 | Mus musculus (House mouse) | |
Q13263 TRIM28 TIF1B_HUMAN |
486 | 490 | SGLMRKVPRVSLERLDLDLT | TP | 6 | Homo sapiens (Human) | |
Q9QWF0 Chaf1a CAF1A_MOUSE |
222 | 226 | LLFIEKVPVVVLEDILATKP | TP | 1 | Mus musculus (House mouse) | |
P20193 Su(var)3-7 SUV37_DROME |
394 | 398 | PEDAQDTPVVMMNGDVDSGD | TP | 1 | Drosophila melanogaster (Fruit fly) | |
O00268 TAF4 TAF4_HUMAN |
764 | 768 | QVTLTQTPMVALRQPHNRIM | TP | 1 | Homo sapiens (Human) | |
O15164 TRIM24 TIF1A_HUMAN |
713 | 717 | ADSTHKVPVVMLEPIRIKQE | TP | 2 | Homo sapiens (Human) | |
Q9VI63 Alh Q9VI63_DROME |
1051 | 1055 | AVPATTSPLVVLSNQLPLNS | TP | 2 | Drosophila melanogaster (Fruit fly) | |
P12956 XRCC6 XRCC6_HUMAN |
352 | 356 | LMLMGFKPLVLLKKHHYLRP | TP | 2 | Homo sapiens (Human) | |
Q13111 CHAF1A CAF1A_HUMAN |
238 | 242 | ILFKGKVPMVVLQDILAVRP | TP | 1 | Homo sapiens (Human) |
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement