The Eukaryote Linear Motif resource for Functional Sites in Proteins
LIG_HOMEOBOX 170
 
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Functional site class: Homeodomain ligand
Functional site description: The YPWM motif in HOX proteins confers binding to PBX homeobox domains.
ELMs: LIG_HOMEOBOX
Description: The Homeobox (Hox) family consists of a large number of transcription factors which have a vital role in development of the embryo in determining the anterior/posterior and rosto/caudal axis in multicellular organisms. Hox proteins share a conserved 60 amino-acid region; homeodomain, 7979246, which has specific DNA binding activity, and promotes regulation of multiple target genes. The YPWM functional site, 1359544, is found in several Hox proteins and is located N-terminal in respect to the homeodomain, and acts as a ligand to the extended Pbx homeodomain, forming a hetrodimer. This interaction increases the DNA binding affinity of the Hox proteins containing the YPWM functional site. The structure suggests, 12409300 & 1LFU, a lock and key mechanism where the YPWM motif engages in an interaction in a hydrophobic pocket located in the extended Pbx homeodomain.
Pattern: [FY][DEP]WM (Probability: 0.0000010)
Present in taxons: Metazoa
PDB Structure: 1B72
<img src="/media/pdb.ico.png"/><a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1B72" target="_blank">1B72</a>
Interaction Domain:

Homeobox (PF00046)
Homeobox domain
(Stochiometry: 1 : 1)

o See 16 Instances for LIG_HOMEOBOX


o Abstract

The YPWM motif in HOX proteins confers binding to PBX homeodomains.

o 2 selected references:

o 4 GO-Terms:

o 16 Instances for LIG_HOMEOBOX
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
HXC8_HUMAN 139 142 QNSSPSLMFPWMRPHAPGRR true positive --- Homo sapiens (Human)
HXA1_HUMAN 205 208 ETSSPAQTFDWMKVKRNPPK true positive --- Homo sapiens (Human)
HXB2_HUMAN 95 98 PAAPPAPEFPWMKEKKSAKK true positive --- Homo sapiens (Human)
HXB4_HUMAN 142 145 SACKEPVVYPWMRKVHVSTV true positive --- Homo sapiens (Human)
HXB5_HUMAN 177 180 PEGQTPQIFPWMRKLHISHD true positive --- Homo sapiens (Human)
HXB8_HUMAN 135 138 QSPSPTQLFPWMRPQAAAGR true positive --- Homo sapiens (Human)
HXD4_HUMAN 134 137 ALKQPAVVYPWMKKVHVNSV true positive --- Homo sapiens (Human)
PDX1_HUMAN 119 122 EPNRVQLPFPWMKSTKAHAW true positive --- Homo sapiens (Human)
TLX1_HUMAN 174 177 VNNLTGLTFPWMESNRRYTK true positive --- Homo sapiens (Human)
TLX2_HUMAN 118 121 AGGLAGLTFPWMDSGRRFAK true positive --- Homo sapiens (Human)
CDX1_HUMAN 133 136 PGAQRPTPYEWMRRSVAAGG true positive --- Homo sapiens (Human)
HXB1_HUMAN 180 183 PNTPTARTFDWMKVKRNPPK true positive 1B72
 Homo sapiens (Human)
HXB3_HUMAN 130 133 NSTLTKQIFPWMKESRQTSK true positive --- Homo sapiens (Human)
HXB6_HUMAN 128 131 EQKCSTPVYPWMQRMNSCNS true positive --- Homo sapiens (Human)
TLX3_HUMAN 125 128 VSSLGGLNFPWMESSRRFVK true positive --- Homo sapiens (Human)
HXB7_HUMAN 127 130 AAESNFRIYPWMRSSGTDRK true positive --- Homo sapiens (Human)

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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