| ELM Identifier | Description | RegEx | Instances | Instances in PDB | Articles.ELM |
|---|---|---|---|---|---|
| DEG_CRL4_CDT2_1 | This degron overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. | [NQ]{0,1}..[ILMV][ST][DEN][FY][FY].{2,3}[KR]{2,3}[^DE] | 6 | 0 | articles.ELM |
| DEG_CRL4_CDT2_2 | This degron, occurring in non-Vertebrates, overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. | [NQ]{0,1}..[ILMV]T[DEN][HMFY][FMY].{2,3}[KR]{2,3}[^DE] | 1 | 0 | articles.ELM |
| DOC_CYCLIN_D_Helix_1 | The Cyclin D Helical docking motif mediates binding of substrates to a site on Cyclin D different from the hydrophobic pocket and enhances substrate phosphorylation by CyclinD/Cdk4-6 complexes. | [FLV][^P][^P][KR]L[^P][^P][LMIV][^P][^P][^P]R | 3 | 0 | articles.ELM |
| LIG_14-3-3_CanoR_1 | Canonical Arg-containing phospho-motif mediating a strong interaction with 14-3-3 proteins. | R[^DE]{0,2}[^DEPG]([ST])(([FWYLMV].)|([^PRIKGN]P)|([^PRIKGN].{2,4}[VILMFWYP])) | 65 | 16 | articles.ELM |
| LIG_14-3-3_ChREBP_3 | 14-3-3 protein binding to a nonphosphorylated helical peptide in ChREBP is promoted by Adenosine monophosphate. | IR[^P][^P]N[^P][^P]WR[^P]W[YFH][ITML][^P]Y[IVL] | 1 | 1 | articles.ELM |
| LIG_14-3-3_CterR_2 | C-terminal Arg-containing phospho-motif mediating a strong interaction with 14-3-3 proteins. | R[^DE]{0,2}[^DEPG]([ST])[^P]{0,1}$ | 6 | 1 | articles.ELM |
| LIG_ActinCP_CPI_1 | The conserved capping protein interaction (CPI) motif is employed by a diverse set of proteins to allosterically down-regulate actin filament capping by CP and thereby fine-tune actin assembly dynamics. | L.(([H].[TQVG])|([SC].N)|(D.R))..R[PAVT][KRHM][^DEN].{1,5}((R.)|(.[RK]))..[PAS][^P] | 15 | 4 | articles.ELM |
| LIG_ActinCP_TwfCPI_2 | The highly conserved twinfilin-type actin capping protein interaction (CPI) motif is employed by twinfilins to maintain the dynamic actin capping/decapping cycles of CP and to counterbalance the effects of negative regulators. | F.[KR]P..[PAS].{0,3}[RK] | 4 | 3 | articles.ELM |
| LIG_Actin_RPEL_3 | RPEL motif, present in proteins in several repeats, mediates binding to the hydrophobic cleft created by subdomains 1 and 3 of G-actin. | [IL]..[^P][^P][^P][^P]R.....[IL]..[^P][^P][ILV][ILM] | 13 | 3 | articles.ELM |
| LIG_Actin_WH2_1 | WH2 is a motif of variable length (16-19 amino acids) binding to the hydrophobic cleft formed by actin's subdomains 1 and 3. At the N-terminus it forms an alpha-helix followed by a flexible loop stabilised upon actin binding. | R..[ILVMF][ILMVF][^P][^P][ILVM].{4,7}L(([KR].)|(NK))[VATI] | 9 | 4 | articles.ELM |
| LIG_Actin_WH2_2 | The WH2 motif is of variable length (16-19 amino acids) binding to the hydrophobic cleft formed by actin's subdomains 1 and 3. At the N-terminus it forms an alpha-helix followed by a flexible loop stabilised upon actin binding. | [^R]..((.[ILMVF])|([ILMVF].))[^P][^P][ILVM].{4,7}L(([KR].)|(NK))[VATIGS] | 17 | 2 | articles.ELM |
| LIG_ANK_PxLPxL_1 | The consensus PxLPxI/L motif, which can be found in diverse proteins, binds to the ankyrin repeat domains of ANKRA2 and its close paralog RFXANK. | P.LP.[IL].{1,3}[VLF] | 10 | 5 | articles.ELM |
| LIG_AP2alpha_1 | FxDxF motif responsible for the binding of accessory endocytic proteins to the appendage of the alpha-subunit of adaptor protein complex AP-2 | F.D.F | 11 | 2 | articles.ELM |
| LIG_AP2alpha_2 | DPF/W motif binds alpha and beta subunits of AP2 adaptor complex. | DP[FW] | 54 | 2 | articles.ELM |
| LIG_APCC_ABBA_1 | Amphipathic motif that is involved in APC/C inhibition by binding of CDH1/CDC20. In metazoan cyclin A, the motif also acts as a degron, enabling the cyclin's degradation in prometaphase. | [ILVMF].[ILMVP][FHY].[DE] | 11 | 1 | articles.ELM |
| LIG_APCC_ABBAyCdc20_2 | Amphipathic motif that binds to yeast Cdc20 and acts as an APC/C degron enabling cyclin Clb5 degradation during mitosis. | [KR]..[ILVM][FHY].[DE] | 2 | 0 | articles.ELM |
| LIG_APCC_Cbox_1 | Motif in APC/C co-activators that mediates binding to the APC/C core, possibly the catalytic Apc2 subunit. This first variant defines the motif in APC/C co-activators from Bacteria759 except Fungi and Amoebozoa. | [DE]R[YFH][ILFVM][PAG].R | 2 | 0 | articles.ELM |
| LIG_APCC_Cbox_2 | Motif in APC/C co-activators that mediates binding to the APC/C core, possibly the catalytic Apc2 subunit. This second variant defines the motif in APC/C co-activators from Fungi and Amoebozoa. | DR[YFH][ILFVM][PA].. | 3 | 0 | articles.ELM |
| LIG_AP_GAE_1 | The acidic Phe motif mediates the interaction between a set of accessory proteins and the gamma-ear domain (GAE) of GGAs and AP-1. Proposed roles: in clathrin localization and assembly on TGN/endosome membranes and in traffic between the TGN and endosome. | [DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD] | 11 | 0 | articles.ELM |
| LIG_Arc_Nlobe_1 | Binding motif for the N-lobe part of the C-terminal domain in Arc. The N-lobe domain has structural homology with HIV virus capsid, but the binding appears to be unique to higher vertebrates. | [^P][P]G{0,1}[^P][YFH][^P] | 11 | 4 | articles.ELM |
| LIG_ARL_BART_1 | The ligand motif present at the N-terminus of ARL2 and ARL3 proteins ensures GTD-dependent binding to BART and BARTL1 | ^..LL[^P]IL[^P][^P][LM] | 2 | 2 | articles.ELM |
| LIG_ARS2_EDGEI_1 | Several proteins functioning in RNA decay/processing/splicing bind a positively charged patch on the C-terminal leg domain (a znF) of ARS2 through their negatively charged EDGEI motif. | E[ED]G[EQ][ILVM].{0,2}[DE] | 21 | 1 | articles.ELM |
| LIG_BH_BH3_1 | The BH3 motif is found in pro-apoptotic proteins and interacts with BH domains of the anti-apoptotic Bcl-2 family members to regulate apoptosis. | ....[LIFVYMTE][ASGC][^P]{2}L[^P]{2}[IVMTL][GACS][D][^P][FVLMI]. | 19 | 8 | articles.ELM |
| LIG_BIR_II_1 | These IBMs are found in pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type II BIR domains. | ^M{0,1}[AS]... | 0 | 0 | articles.ELM |
| LIG_BIR_III_1 | These IBMs are found in pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type III BIR domains. | ^M{0,1}A.P. | 1 | 0 | articles.ELM |
| LIG_BIR_III_2 | These IBMs are found at the N-terminal regions of caspase subunits where they mediate the inhibition of activated caspases by binding to conserved surface grooves on type III BIR domains of Inhibitor of Apoptosis Proteins (IAPs). | DA.P. | 3 | 1 | articles.ELM |
| LIG_BIR_III_3 | These IBMs are found in arthropodal pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type III BIR domains of arthropodal IAPs. | ^M{0,1}A.[AP]. | 4 | 3 | articles.ELM |
| LIG_BIR_III_4 | These IBMs are found in the N-terminal regions of arthropodal caspase subunits where they mediate the inhibition of activated caspases by binding to conserved surface grooves on type III BIR domains of Inhibitor of Apoptosis Proteins (IAPs). | DA.G. | 2 | 0 | articles.ELM |
| LIG_BRCT_BRCA1_1 | Phosphopeptide motif which directly interacts with the BRCT (carboxy-terminal) domain of the Breast Cancer Gene BRCA1 with low affinity | .(S)..F | 5 | 3 | articles.ELM |
| LIG_BRCT_BRCA1_2 | Phosphopeptide motif which directly interacts with the BRCT (carboxy-terminal) domain of the Breast Cancer Gene BRCA1 with high affinity. | .(S)..F.K | 1 | 1 | articles.ELM |
| LIG_BRCT_MDC1_1 | Phosphopeptide motif which is specifically recognized by the BRCT (Carboxy-terminal) repeats of MDC1 | .(S)..Y$ | 1 | 1 | articles.ELM |
| LIG_CaM_IQ_9 | Helical peptide motif responsible for Ca2+-independent binding of the CaM . The motif is manly characterized by a hydrophobic residue at position 1, a highly conserved Gln at position 2, basic charges at positions 6 and 11, and a variable Gly at position 7 | [ACLIVTM][^P][^P][ILVMFCT]Q[^P][^P][^P][RK][^P]{4,5}[RKQ][^P][^P] | 75 | 10 | articles.ELM |
| LIG_CaMK_CASK_1 | Motif that mediates binding to the calmodulin-dependent protein kinase (CaMK) domain of the peripheral plasma membrane protein CASK/Lin2. | [STED].{0,2}[IV]W[IVLM].[RHK] | 7 | 3 | articles.ELM |
| LIG_CaM_NSCaTE_8 | Short motif recognized by CaM that is only present in the Cav1.2 and Cav1.3 L-type calcium channels. | W[^P][^P][^P][IL][^P][AGS][AT] | 3 | 0 | articles.ELM |
| LIG_CAP-Gly_1 | Short, acidic and aromatic carboxy terminal sequence found in a small group of microtubule-associated-proteins. The EEY/F$ motif is highly conserved and so far limited to a few known proteins, alpha-tubulin, EB proteins and CLIP170. | [ED].{0,2}[ED].{0,2}[EDQ].{0,1}[YF]$ | 3 | 3 | articles.ELM |
| LIG_CAP-Gly_2 | Short, partly aromatic carboxy terminal sequence found in the SLAIN group of microtubule-associated-proteins. | .W[RK][DE]GCY$ | 1 | 1 | articles.ELM |
| LIG_Clathr_ClatBox_1 | Clathrin box motif found on cargo adaptor proteins, it interacts with the beta propeller structure located at the N-terminus of Clathrin heavy chain. | L[IVLMF].[IVLMF][DE] | 18 | 3 | articles.ELM |
| LIG_Clathr_ClatBox_2 | Clathrin box motif found on cargo adaptor proteins, it mediates binding to the N-terminal beta propeller of clathrin heavy chain. Also called W box, it is found in the central region of Amphiphysins where it coexists with a "classical" clathrin box. | .[NP]W[DES].W | 2 | 1 | articles.ELM |
| LIG_CNOT1_NIM_1 | The CNOT1-interacting motif (NIM) found in Nanos proteins mediates recruitment of the CCR4-NOT deadenylase complex. | [FY][^P].[WFY][^P]DY..L | 10 | 1 | articles.ELM |
| LIG_CORNRBOX | The corepressor nuclear receptor box motif confers binding to nuclear receptors. | L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] | 4 | 3 | articles.ELM |
| LIG_CSK_EPIYA_1 | Csk Src Homology 2 (SH2) domain binding EPIYA motif | EP[IL]Y[TAG] | 20 | 0 | articles.ELM |
| LIG_CSL_BTD_1 | The motif mediates the interaction between a Notch-like protein and the transcription factor CSL by placing two amino acids (W and P) into a hydrophobic pocket of the BTD domain of CSL. | [AFILMPTVW]W[FHILMPSTVW]P | 18 | 2 | articles.ELM |
| LIG_CtBP_PxDLS_1 | The PxDLS motif interacts with the NAD-dependent repressor CtBP proteins. | (P[LVIPME][DENS][LM][VASTRG])|(G[LVIPME][DENS][LM][VASTRG]((K)|(.[KR]))) | 32 | 0 | articles.ELM |
| LIG_CtBP_RRT_2 | The RRT motif binds to a groove on the nucleotide binding domain of CtBP proteins functioning as NAD-dependent transcriptional corepressors. | [RG]RT[GSAT].PP.. | 5 | 0 | articles.ELM |
| LIG_DCNL_PONY_1 | DCNL PONY domain binding motif variant based on the UBE2M and UBE2F interactions. | ^M[MIL].[MIL] | 2 | 0 | articles.ELM |
| LIG_deltaCOP1_diTrp_1 | Tryptophan-based motifs enable targeting of the tethering and (dis)assembly factors to the C-terminal mu homology domain (MHD) of the coatomer subunit delta, delta-COP. | [DE]{1,3}.{0,2}W.{1,6}[WF] | 5 | 2 | articles.ELM |
| LIG_DLG_GKlike_1 | The guanylate kinase-like domain of DLG family membrane-associated scaffolding proteins binds phosphorylated motifs in SAPAPs and other protein partners. | (R..(S)[YFLM][^P][^P][L])|(R..(S)[YFLM][^P][^P][ASG][LMVIQT]) | 14 | 4 | articles.ELM |
| LIG_Dynein_DLC8_1 | The [KR]xTQT motif interacts with the common target-accepting grooves of 8kDa Dynein Light Chain dimer. | [^P].[KR].TQT | 9 | 4 | articles.ELM |
| LIG_EABR_CEP55_1 | This proline-rich motif binds to the EABR domain of Cep55 and is involved in both cytokinesis of somatic cells and intercellular bridge formation in differentiating germ cells. | .A.GPP.{2,3}Y. | 6 | 1 | articles.ELM |
| LIG_EF_ALG2_ABM_1 | This isoform-specific ALG-2-binding motif binds to the EF hand domains of the proapoptotic Ca2+-binding ALG-2 protein in a Ca2+-dependent manner. | P[PG]{0,1}YP.{1,6}Y[QS]{0,1}P | 9 | 1 | articles.ELM |
| LIG_EF_ALG2_ABM_2 | This isoform-unspecific ALG-2-binding motif binds to the EF hand domains of the proapoptotic Ca2+-binding ALG-2 protein in a Ca2+-dependent manner. | P.P.{0,1}GF | 3 | 0 | articles.ELM |
| LIG_EH_1 | NPF motif interacting with EH domains, usually during regulation of endocytotic processes | .NPF. | 88 | 3 | articles.ELM |
| LIG_EH1_1 | The engrailed homology domain 1 motif is found in homeodomain containing active repressors and other transcription families, and allows for the recruitment of Groucho/TLE corepressors. | .[FYH].[IVM][^WFYP][^WFYP][ILM][ILMV]. | 11 | 1 | articles.ELM |
| LIG_eIF4E_1 | Motif binding to the dorsal surface of eIF4E. | Y....L[VILMF] | 13 | 0 | articles.ELM |
| LIG_eIF4E_2 | Atypical variant of eIF4E motif. | Y.PP.[ILMV]R | 5 | 0 | articles.ELM |
| LIG_EVH1_1 | Proline-rich motif binding to signal transduction class I EVH1 domains. | ([FYWL]P.PP)|([FYWL]PP[ALIVTFY]P) | 19 | 3 | articles.ELM |
| LIG_EVH1_2 | Proline-rich motif binding to signal transduction class II EVH1 domains. | PP..F | 8 | 1 | articles.ELM |
| LIG_EVH1_3 | A proline-rich motif binding to EVH1/WH1 domains of WASP and N-WASP proteins. | [FY].[FW].....[LMVIF]P.P[DE] | 3 | 1 | articles.ELM |
| LIG_FAT_LD_1 | The paxillin LD motif is recognized by FAK and other focal adhesion proteins mainly involved in cytoskeletal regulation | [LV][DE][^P][LM][LM][^P][^P]L[^P] | 4 | 2 | articles.ELM |
| LIG_FERM_MyoX_1 | Motif specifically recognized by the MyTH4-FERM domain of MyosinX that is important for cargo recognition. | L...M[^P][^P]L[^P][^P]LM[^P][QD]L[^P][^P]I[TA] | 4 | 2 | articles.ELM |
| LIG_FHA_1 | Phosphothreonine motif binding a subset of FHA domains that show a preference for a large aliphatic amino acid at the pT+3 position. | ..(T)..[ILV]. | 6 | 3 | articles.ELM |
| LIG_FHA_2 | Phosphothreonine motif binding a subset of FHA domains that have a preference for an acidic amino acid at the pT+3 position. | ..(T)..[DE]. | 6 | 2 | articles.ELM |
| LIG_FXI_DFP_1 | The DFP motif enables binding to the 2nd apple domain of coagulation factor XI (FXI) and plasma kallikrein heavy chain. | [FYWHIL].DF[PD] | 5 | 2 | articles.ELM |
| LIG_FZD_DVL_PDZ | A short internal motif near the C-terminus of Frizzleds, which interacts with the PDZ domain of DVL in Wnt pathway. | W.{0,1}[VIL].[ST].KA{0,1}T...W | 9 | 0 | articles.ELM |
| LIG_G3BP_FGDF_1 | The FGDF motif binds to a hydrophobic binding cleft within the N-terminal NTF2-like domain of the stress granule protein G3BP. | [FYLIMV].FG[DES]F | 9 | 0 | articles.ELM |
| LIG_GBD_Chelix_1 | Amphipatic alpha helix that binds the GTPase-binding domain (GBD) in WASP and N-WASP. | [ILV][VA][^P][^P][LI][^P][^P][^P][LM] | 12 | 3 | articles.ELM |
| LIG_GLEBS_BUB3_1 | Gle2-binding-sequence motif | [EN][FYLW][NSQ].EE[ILMVF][^P][LIVMFA] | 5 | 2 | articles.ELM |
| LIG_GSK3_LRP6_1 | PPPSP motif present on the cytosolic tails of the transmembrane receptors LRP5 and LRP6, responsible for GSK3 binding and inhibition when phosphorylated. | (([CP]PP)|(PP[TP]))[ST]P[^P][TS]{0,1} | 8 | 0 | articles.ELM |
| LIG_GYF | LIG_GYF is a proline-rich sequence specifically recognized by GYF domains | [QHR].{0,1}P[PL]PP[GS]H[RH] | 3 | 1 | articles.ELM |
| LIG_HCF-1_HBM_1 | The DHxY Host Cell Factor-1 binding motif (HBM) interacts with the N-terminal kelch propeller domain of the cell cycle regulator HCF-1 | [DE]H.Y | 17 | 0 | articles.ELM |
| LIG_HOMEOBOX | The YPWM motif confers binding to the PBX homeobox domain | [FY][DEP]WM | 16 | 1 | articles.ELM |
| LIG_HP1_1 | Ligand to interface formed by dimerisation of two chromoshadow domains in HP1 proteins. | P[MVLIRWY]V[MVLIAS][LM] | 9 | 1 | articles.ELM |
| LIG_IBAR_NPY_1 | A short NPY motif present in the bacterial effector protein Tir binds the I-BAR domain and is involved in actin polymerization | NPY | 7 | 1 | articles.ELM |
| LIG_Integrin_collagen_1 | A collagen-specific binding motif that is recognized by the I-domain of collagen binding integrins α1β1, α2β1, α10β1, α11β1 | G[FLMR](P)GE[RKNA] | 7 | 4 | articles.ELM |
| LIG_Integrin_isoDGR_2 | NGR motif is present in proteins of extracellular matrix which upon deamidation forms a biologically active isoDGR motif that binds to various members of integrin family. | NGR | 8 | 0 | articles.ELM |
| LIG_Integrin_KxxGD_FGGC_5 | An αIIbβ3 integrin-specific, C-terminal variant of the RGD motif where a displaced lysine substitutes for the canonical arginine. | K.[AV]GD.$ | 5 | 1 | articles.ELM |
| LIG_Integrin_RGD_1 | The RGD motif can be found in many extracellular proteins and is recognized by different members of the integrin family. The structure of the tenth type III module of fibronectin shows that the RGD motif lies on an exposed flexible loop. | RGD | 25 | 2 | articles.ELM |
| LIG_Integrin_RGDSP_6 | A variant of the canonical RGD motif minimizing flanking interactions with the integrin, thus achieving weak selectivity and comparable binding strength over all RGD-binding integrins | RGDSP{0,1} | 6 | 1 | articles.ELM |
| LIG_Integrin_RGD_TGFB_3 | A C-terminally extended subtype of the canonical RGD motif strongly binding to integrins αvβ6 and αvβ8. | RGDL[^P][^P][LI] | 5 | 4 | articles.ELM |
| LIG_Integrin_RGDW_4 | A C-terminally extended subtype of the canonical RGD motif strongly binding to integrins αIIbβ3 and αvβ3. | [RK]GDW | 18 | 0 | articles.ELM |
| LIG_IRF7_LxLS_2 | A binding site for IRF-7 present in the protein itself, in various innate adaptor proteins, and in rotaviral NSP1 which triggers the innate immune responsive pathways. | [VILPFYM].{1,3}L.L(S) | 1 | 0 | articles.ELM |
| LIG_IRFs_LxIS_1 | A binding site for proteins IRF-3, IRF-5 and IRF-6 present in the protein themselves, in various innate adaptor proteins, and in rotaviral NSP1 which triggers the innate immune responsive pathways. | [VILPFYM].{1,3}L.I(S) | 9 | 6 | articles.ELM |
| LIG_KEPE_1 | Short length variant of the KEPE motif which is found superposed on some SUMO sites | [VILMFT]K.EP.[DE] | 5 | 0 | articles.ELM |
| LIG_KEPE_2 | Medium length variant of the KEPE motif which is found superposed on some SUMO sites | [VILMFT]K.EP.{2,3}[DE] | 12 | 0 | articles.ELM |
| LIG_KEPE_3 | Long length variant of the KEPE motif which is found superposed on some SUMO sites | [VILMFT]K.EP....[DE] | 4 | 0 | articles.ELM |
| LIG_KLC1_WD_1 | This short WD or WE motif is found in cargo proteins and mediates kinesin-1-dependent microtubule transport by binding to the KLC TPR region. | [LMTAFSRI][^KRG]W[DE].{3,5}[LIVMFPA] | 22 | 1 | articles.ELM |
| LIG_KLC1_Yacidic_2 | A kinesin cargo motif binding to the TPR domain of KLC1 found in JIP1 and TorsinA. | [ED].{0,1}[IYVLMTF]Y[LIV][DE] | 3 | 2 | articles.ELM |
| LIG_LEDGF_IBM_1 | A bipartite motif recognized by the integrase binding domain of LEDGF/p75 | [LFVIM].{2,3}[LIVCYFM][FW].{3,35}[EDST].{0,1}[EDST].{0,1}F[^G]GF | 9 | 3 | articles.ELM |
| LIG_LIR_Apic_2 | Apicomplexa specific variant of the canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. | [EDST].{0,2}[WFY]..P | 1 | 1 | articles.ELM |
| LIG_LIR_Gen_1 | Canonical LIR motif that binds to Atg8/LC3 protein family members to mediate processes involved in autophagy. | [EDST].{0,2}[WFY][^RKPGWFY][^PG][ILVFM]((.{0,4}[PLAFIVMY])|($)|(.{0,3}[ED])) | 54 | 26 | articles.ELM |
| LIG_LIR_LC3C_4 | Non-canonical variant of the LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. | [EDST].{0,2}LVV | 1 | 1 | articles.ELM |
| LIG_LIR_Nem_3 | Nematode-specific variant of the canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. | [EDST].{0,2}[WFY]..[ILVFY] | 11 | 1 | articles.ELM |
| LIG_LRP6_Inhibitor_1 | Short motif present in extracellular of some Wnt antagonists recognized by the N-terminal β-propeller domain of LRP5/6 and thus inhibits the Wnt pathway. | ([VILA]..N.I[RK])|([VILA].PN.IG.{0,6}[RK]) | 3 | 2 | articles.ELM |
| LIG_LSD1_SNAG_1 | A repressor motif found in some zinc finger transcription factors binds to the amine oxidase domain of LSD1. | ^M{0,1}PR.FLV[KR]K{0,1}. | 11 | 1 | articles.ELM |
| LIG_LYPXL_L_2 | The long version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting. | [ILVM]YP...[ILVM][^P][^P][LI] | 4 | 3 | articles.ELM |
| LIG_LYPXL_S_1 | The short version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting. | [ILVMF]YP.[ILVMF] | 19 | 1 | articles.ELM |
| LIG_LYPXL_SIV_4 | The SIV helical version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting. | [PA]Y..[AV][^P]{3}L | 3 | 2 | articles.ELM |
| LIG_LYPXL_yS_3 | The yeast short version of the LYPxL motif binds the V-domain of Bro1 and Rim20, proteins involved in endosomal sorting and pH signalling. | YP.[ILVM] | 2 | 0 | articles.ELM |
| LIG_MAD2 | Mad2 binding motif | [KR][IV][LV].....P | 6 | 1 | articles.ELM |
| LIG_Menin_MBM1_1 | High affinity motif recognized by the palm region of Menin protein | ...[RK][^DE]{0,2}FP[GA][^DE]P | 4 | 2 | articles.ELM |
| LIG_MLH1_MIPbox_1 | Proteins involved in DNA repair and replication employ conserved MIP-box motifs to bind the C-terminal domain of mismatch repair protein MLH1. | .S.[FY][F] | 6 | 2 | articles.ELM |
| LIG_MSH2_SHIPbox_1 | The aromatic SHIP box motif is employed by several positive regulators of DNA mismatch repair (MMR) to interact with MSH2 | [LIVMFWYTA].{2,3}[LI][^P]{2,3}[FY].[FYW] | 10 | 0 | articles.ELM |
| LIG_MTR4_AIM_1 | Diverse nuclear exosome adaptors employ the so-called arch-interacting motif (AIM) to recruit the MTR4-exosome complex to different RNA species for facilitating their efficient degradation. | [FYW][^P][VILTM]D.(([^P][GPAS])|G) | 8 | 4 | articles.ELM |
| LIG_Mtr4_Air2_1 | This motif on Air2 interacts with the DExH core of Mtr4, forming a part of the nucleus-located TRAMP complex. The motif is conserved in fungi. | GRYFG | 3 | 1 | articles.ELM |
| LIG_Mtr4_Trf4_1 | This motif on Trf4 interacts with the DExH core of Mtr4, forming a part of the nucleus-located TRAMP complex. The motif is conserved in Fungi. | [LFVAIMW].{3,5}[DE][FY][IL][SAPGK][FL].{3,6}[DE]{3} | 4 | 1 | articles.ELM |
| LIG_Mtr4_Trf4_2 | This motif on PAPD5 interacts with the DExH core of SKIV2L2, forming a part of the nucleus-located TRAMP complex. The predicted motif is conserved in Vertebrates. | Q[RGQ]DF[LI][PS]L[DE] | 3 | 0 | articles.ELM |
| LIG_MYND_1 | PxLxP motif is recognized by a subset of MYND domain containing proteins. | P.L.P | 6 | 0 | articles.ELM |
| LIG_MYND_2 | Motif that mediates the interaction between MYND domain of AML1/ETO and co-repressors SMRT and N-CoR. | PP.LI | 3 | 1 | articles.ELM |
| LIG_MYND_3 | A variant MYND binding motif found in the HSP90 co-chaperones p23 and FKBP38 interacting with PHD2 MYND domain. | [LMV]P.LE | 2 | 0 | articles.ELM |
| LIG_NBox_RRM_1 | Amino terminal region on Far Upstream Element (FUSE) binding protein (Q96AE4), which mediates the interaction with FIR in order to recruit FIR (Q9UHX1) to FUSE DNA. | F..A[ILV]..A..[ILV] | 2 | 1 | articles.ELM |
| LIG_NRBOX | The nuclear receptor box motif (LXXLL) confers binding to nuclear receptors. | [^P]L[^P][^P]LL[^P] | 24 | 5 | articles.ELM |
| LIG_Nrd1CID_NIM_1 | The CTD-interacting domain (CID) of Nrd1 interacts with the NIM motif in Trf4 and some other proteins in ncRNA degradation | [ED].{0,3}[DN][DEGPA]Y.[PL].. | 5 | 4 | articles.ELM |
| LIG_NRP_CendR_1 | The CendR motif has a carboxy-terminal arginine, which binds to the Neuropilin b1 domain binding site. CendR motifs are either located at the protein C-terminus or are generated by internal cleavage by a polybasic protease, such as Furin | [RK].{0,2}R$ | 12 | 4 | articles.ELM |
| LIG_OCRL_FandH_1 | The F and H motif describes a 10-13-mer peptide sequence determined by a highly conserved phenylalanine and histidine residue surrounded by hydrophobic amino acids. A complex of ASH and RhoGAP-like domain binds this motif within a hydrophobic pocket. | .F[^P][^P][KRIL]H[^P][^P][YLMFH][^P]... | 3 | 1 | articles.ELM |
| LIG_PALB2_WD40_1 | A motif present in the BRCA2 protein which binds to the WD 40 repeat (blade 4,5) domain of PALB2 which is required for the recognition of DNA double strand breaks and repair. | ....WF..L | 1 | 1 | articles.ELM |
| LIG_PAM2_1 | Peptide ligand motif that directly binds to the MLLE/PABC domain found in poly(A)-binding proteins and HYD E3 ubiquitin ligases, mainly via a common central core region and a complementary N-terminal region. | ..[LFP][NS][PIVTAFL].A..(([FY].[PYLF])|(W..)). | 22 | 6 | articles.ELM |
| LIG_PAM2_2 | Peptide ligand motif that directly binds to the MLLE/PABC domain found in poly(A)-binding proteins and HYD E3 ubiquitin ligases, mainly via a common central core region and a complementary C-terminal region. | ((WPP)|([FL][PV][APQ]))EF.PG.PWKG. | 4 | 1 | articles.ELM |
| LIG_PCNA_APIM_2 | The PCNA-binding APIM motif is found in proteins involved in DNA repair and cell cycle control | [MLIV].[KR][FY][MLIVF][LIV][KR] | 2 | 1 | articles.ELM |
| LIG_PCNA_PIPBox_1 | The PCNA binding motifs include the PIP Box and the APIM motif, and are found in proteins involved in DNA replication, repair, methylation and cell cycle control. | [QM].[^FHWY][LIVM][^P][^PFWYMLIV](([FYHL][FYW])|([FYH][FYWL])).. | 19 | 10 | articles.ELM |
| LIG_PCNA_TLS_4 | The PCNA binding motifs include the PIP Box, PIP degron, the APIM and the TLS motif. These motifs are found in proteins involved in DNA replication, repair, methylation and cell cycle control. | [KR]..[ILM](([DE][^P][FY][FLI])|([G][^P][FY][FLI].{0,1}[KR])) | 3 | 2 | articles.ELM |
| LIG_PCNA_yPIPBox_3 | The PCNA binding motifs include the PIP Box, PIP degron and the APIM motif, and are found in proteins involved in DNA replication, repair, methylation and cell cycle control. This is the variant for the yeast PIPbox | ([KR].{0,6}[QN].[^FHWY][LIVM][^P][^PFWYMLIV][FYLMWV][FYLMWVI])|([QN].[^FHWY][LIVM][^P][^PFWYMLIV][FYLMWV][FYLMWVI].{0,6}[KR]) | 12 | 2 | articles.ELM |
| LIG_PDZ_Class_1 | The C-terminal class 1 PDZ-binding motif is classically represented by a pattern like (ST)X(VIL)* | ...[ST].[ACVILF]$ | 52 | 24 | articles.ELM |
| LIG_PDZ_Class_2 | The C-terminal class 2 PDZ-binding motif is classically represented by a pattern such as (VYF)X(VIL)* | ...[VLIFY].[ACVILF]$ | 13 | 8 | articles.ELM |
| LIG_PDZ_Class_3 | The C-terminal class 3 PDZ-binding motif is classically represented by a pattern such as (DE)X(VIL)* | ...[DE].[ACVILF]$ | 1 | 1 | articles.ELM |
| LIG_PDZ_Wminus1_1 | The C-terminal Trp-1 PDZ-binding motif is represented by a pattern like W(ACGILV)$ | .W[ACGILV]$ | 27 | 3 | articles.ELM |
| LIG_Pex14_1 | Wxxx[FY] motifs present in N-terminal half of Pex5 bind to Pex13 and Pex14 at peroxisomal and glycosomal membranes to facilitate entrance of PTS1 cargo proteins into the organellar lumen. | W...[FY] | 27 | 1 | articles.ELM |
| LIG_Pex14_2 | Fxxx[WF] motifs are present in Pex19 and S. cerevisiae Pex5 cytosolic receptors that bind to peroxisomal membrane docking member, Pex14 | F...[WF] | 2 | 0 | articles.ELM |
| LIG_Pex14_3 | Motif in Pex5 interacting with the N-terminal domain (NTD) of Pex14 | LV.EF[LM] | 1 | 1 | articles.ELM |
| LIG_Pex14_4 | Fungal motif in Pex5 interacting with the N-terminal domain of Pex14 | MM[NDE][EDNAG]F[LMA] | 0 | 0 | articles.ELM |
| LIG_Pex3_1 | LxxLLxxxLxxF motif is located in N-terminus of Pex19 receptors that are responsible for docking to Pex3 docking factor at cis side of peroxisomal membrane. | L..LL...L..F | 1 | 0 | articles.ELM |
| LIG_PROFILIN_1 | The polyproline profilin-binding motif is found in regulators of actin cytoskeleton. | PPP[PA]P((P[LGP])|([LG]P)) | 16 | 4 | articles.ELM |
| LIG_PTAP_UEV_1 | PTAP motif binds the N-terminal UEV domain of Tsg101. | .P[TS]AP. | 28 | 2 | articles.ELM |
| LIG_PTB_Apo_2 | These phosphorylation-independent motifs bind to Dab-like PTB domains. Binding is not driven by contacts at the 0 or FY position, but instead is dependent upon the large number of hydrophobic and hydrogen bond contacts between motif and domain. | (.[^P].NP.[FY].)|(.[ILVMFY].N..[FY].) | 19 | 7 | articles.ELM |
| LIG_PTB_Phospho_1 | This phosphorylation-dependent motif binds to Shc-like and IRS-like PTB domains. The pTyr is positioned within a highly basic-charged anchoring pocket. A hydrophobic residue -5 (compared to pY) increases the affinity of the interaction. | (.[^P].NP.(Y))|(.[ILVMFY].N..(Y)) | 17 | 6 | articles.ELM |
| LIG_RBL1_LxSxE_2 | The LxSxE motif is a suboptimal variant of the LxCxE motif found in the LIN52 protein that interacts with two members of the pocket protein family (p107 and p130). Binding requires phosphorylation of an adjacent residue creating a phosphoswitch | [DE].{0,4}L.S.E.[MLIVAYFWP].{2,4}(S) | 1 | 1 | articles.ELM |
| LIG_RB_LxCxE_1 | The LxCxE motif is found in multiple host and viral interactors of the pocket protein family (Rb, p107 and p130) | ([DEST]|^).{0,4}[LI].C.E.{1,4}[FLMIVAWPHY].{0,8}([DEST]|$) | 48 | 12 | articles.ELM |
| LIG_RB_pABgroove_1 | The LxDLFD motif binds in a deep groove between the A and B subdomains of the Retinoblastoma (Rb), p107 and p130 pocket domains | ..[LIMVA].[DE][LMF][FYM][IL]{0,1}([DE]|(S)). | 7 | 4 | articles.ELM |
| LIG_REV1ctd_RIR_1 | Several DNA repair proteins interact with the C-terminal domain of the Rev1 translesion synthesis scaffold through the Rev1-Interacting Region RIR motif that is centred around two neighbouring Phe residues. |
..FF[^P]{0,2}[KR]{1,2}[^P]{0,4} | 10 | 4 | articles.ELM |
| LIG_RPA_C_Fungi | Fungi version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. | [^P][MIALVF][^P][^P][NSHRA]R[^P][^P][ASV][^P][^P][RKLIA][RQLIVA] | 1 | 0 | articles.ELM |
| LIG_RPA_C_Insects | Insect version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. | [^P][MIAL][^P][^P][NKS][KRLQH][^P][^P]A[^P][^P][RKLI][RKL][^P][^P][KR] | 0 | 0 | articles.ELM |
| LIG_RPA_C_Plants | Plant version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. | R[MIVAS][^P][^P][NQ][KRL][^P][^P]A[^P][^P][RK] | 0 | 0 | articles.ELM |
| LIG_RPA_C_Vert | The RPA interacting motif is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. | [KRS]I[^P][^P][NK][KR][^P][^P]A[^P][^P][RKL][RKL][^P][^P][RK] | 4 | 2 | articles.ELM |
| LIG_RRM_PRI_1 | The PTB RRM2 Interacting (PRI) motif is found in some splicing regulators, possibly only in the chordate lineage. As part of splicing complex regulation, it interacts with the 2nd RNA binding domain (RRM) of PTB, the polypyrimidine tract binding protein. | .[ILVM]LG..P. | 3 | 0 | articles.ELM |
| LIG_Rrp6Rrp47_Mtr4_1 | The motif enables the interaction of Mtr4 like helicases with the Rrp6-Rrp47 heterodimer and thus the formation of the exosome binding complex. | [ED]LF[^P][VC]F.{0,1}[ED] | 5 | 1 | articles.ELM |
| LIG_RuBisCO_WRxxL_1 | The WRxxL RuBisCO-binding motif present in Pyrenoid proteins promotes the assembly of this algal organelle and its different compartments. | [ILVATSRK][^EDN].[NDS]W[RK][^P][^P][LIVAPS] | 20 | 2 | articles.ELM |
| LIG_SH2_CRK | CRK family SH2 domain binding motif. | (Y)[^EPILVFYW][^HDEW][PLIV][^DEW] | 36 | 1 | articles.ELM |
| LIG_SH2_GRB2like | GRB2-like Src Homology 2 (SH2) domains binding motif | (Y)([EDST]|[MLIVAFYHQW])N. | 35 | 10 | articles.ELM |
| LIG_SH2_NCK_1 | NCK Src Homology 2 (SH2) domain binding motif | ([^KR][^KR](Y)[DE][^GWFY][AI][SDENQTAGYFP])|([^KR][^KR](Y)[STNA][^GWFY][PV][SDENQTAGYFP])|(..Y[DE][^GWFY][PV][SDENQTAGYFP]) | 17 | 1 | articles.ELM |
| LIG_SH2_PTP2 | SH-PTP2 and phospholipase C-gamma Src Homology 2 (SH2) domains binding motif. | (Y)[IV].[VILP] | 1 | 0 | articles.ELM |
| LIG_SH2_SFK_2 | Phosphotyrosine motifs bound by SH2 domains of Src family kinases (SFKs) |
[^KR][^KR](Y)([DEVYI][^KRH][ILVF]|[DEVYI][^KRH][AQPMCW]|[NQSTAFL][^KRH][ILVF])((.{0,3}[DE])|.|$) | 20 | 5 | articles.ELM |
| LIG_SH2_SFK_CTail_3 | Internal SH2 binding motif in SRC family kinase C-terminal tails | ((Y)QPG[ED])|((Y)Q.QP$) | 4 | 4 | articles.ELM |
| LIG_SH2_STAP1 | STAP1 Src Homology 2 (SH2) domain Class 2 binding motif | (Y)[DESTA][^GP][^GP][ILVFMWYA] | 22 | 1 | articles.ELM |
| LIG_SH2_STAT3 | YXXQ motif found in the cytoplasmic region of cytokine receptors that bind STAT3 SH2 domain. | (Y)..Q | 9 | 0 | articles.ELM |
| LIG_SH2_STAT5 | STAT5 Src Homology 2 (SH2) domain binding motif. | (Y)[VLTFIC].. | 19 | 0 | articles.ELM |
| LIG_SH2_STAT6 | STAT6 Src Homology 2 (SH2) domain binding motif. | G(Y)[KQ].F | 1 | 0 | articles.ELM |
| LIG_SH3_1 | This is the motif recognized by class I SH3 domains | [RKY]..P..P | 8 | 0 | articles.ELM |
| LIG_SH3_2 | This is the motif recognized by class II SH3 domains | P..P.[KR] | 19 | 6 | articles.ELM |
| LIG_SH3_3 | This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity | ...[PV]..P | 26 | 1 | articles.ELM |
| LIG_SH3_4 | This is the motif recognized by those SH3 domains with a non-canonical class II recognition specificity | KP..[QK]... | 2 | 0 | articles.ELM |
| LIG_SH3_CIN85_PxpxPR_1 | The non-canonical SH3-binding motif is recognized primarily by adaptor proteins CIN85 and CD2AP, which are involved in RTK regulation, endocytosis, lysosomal degradation, actin cytoskeleton dynamics regulation, and signal transduction | P.[AP].PR | 60 | 4 | articles.ELM |
| LIG_SH3_PxRPPK_7 | This PxRPxK subtype of the RxxK motifs is typically employed by GRB2-associated-binding proteins (GABs) 1, 2 and 3, and by other proteins, such as THEMIS, for binding of the C-terminal SH3 domains of GRB2 or GADS. | [PAVL]P[PEQA][RL]PPK[^DE] | 7 | 1 | articles.ELM |
| LIG_SH3_PxxDY_5 | The PxxDY motif is recognized by some SH3 domains including in Nck and Eps8 | P..DY | 7 | 2 | articles.ELM |
| LIG_SH3_PxxPPRxxK_8 | This HPK1 subtype of the RxxK motifs, where the RxxK is preceded by an upstream PxxP, is used by HPK1 and some other proteins mainly in T-cell receptor signalling to interact with the C-terminal SH3 domain of GADS or GRB2. | [PAVLI]P.[LVI]PP[RK][^P][^P][KR] | 6 | 1 | articles.ELM |
| LIG_SH3_PxxxRxxKP_6 | The C-terminal SH3 domains of GADS and GRB2, and the SH3s of STAM1 and STAM2 have been described to bind this canonical RxxK motif. | P.[VIF][DNH]R[^P][^P]KP | 16 | 3 | articles.ELM |
| LIG_Sin3_1 | Motif interacts with PAH2 domain in the Sin3 scaffold protein. | [LIV]..[LM]L.AA.[FY][LI] | 4 | 2 | articles.ELM |
| LIG_Sin3_2 | Motif interacts with PAH2 domain in the Sin3 scaffold protein (sp-1 like). | [FHYM].A[AV].[VAC]L[MV].[MI] | 3 | 0 | articles.ELM |
| LIG_Sin3_3 | Motif interacts with PAH2 domain in the Sin3 scaffold protein (not mad or sp-1 like). | [FA].[LA][LV][LVI]..[AM] | 2 | 0 | articles.ELM |
| LIG_SPRY_1 | Peptide motif binding to the members of the SSB (or SPSB) family (SPRY domain- and SOCS box-containing protein) | [ED][LIV]NNN[^P] | 2 | 2 | articles.ELM |
| LIG_SUFU_1 | A hydrophobic motif in GLI transcription factors required for binding to SUFU protein, which inhibits their activity and hence negatively regulates hedgehog signalling. | [SV][CY]GH[LIF][LAST][GAIV]. | 5 | 2 | articles.ELM |
| LIG_SUMO_SIM_anti_2 | Motif for the antiparallel beta augmentation mode of non-covalent binding to SUMO protein. | [DEST]{1,10}.{0,1}[VIL][DESTVILMA][VIL][VILM].[DEST]{0,5} | 17 | 2 | articles.ELM |
| LIG_SUMO_SIM_par_1 | Motif for the parallel beta augmentation mode of non-covalent binding to SUMO protein. | [DEST]{0,5}.[VILPTM][VIL][DESTVILMA][VIL].{0,1}[DEST]{1,10} | 33 | 4 | articles.ELM |
| LIG_SxIP_EBH_1 | SxIP motifs bind to EBH domains. | ([KR][^ED]{0,5}[ST].IP[^ED]{5,5})|([^ED]{5,5}[ST].IP[^ED]{0,5}[KR]) | 9 | 1 | articles.ELM |
| LIG_TPR | Ligands of the TPR (tetratricopeptide repeat motif) domains are EEVD motifs, C-terminal sequences highly conserved in all eukaryotic members of the Hsp70 and Hsp90 families. | EEVD$ | 9 | 2 | articles.ELM |
| LIG_TRAF2like_MATH_loPxQ_2 | Long (or minor) TRAF2 binding motif. Members of the tumour necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) to their cytoplasmic tails. | [PM][LIVTFYHQE][QS].(([DE].)|(.[DE])) | 5 | 5 | articles.ELM |
| LIG_TRAF2like_MATH_shPxQ_1 | Short (or major) TRAF2 binding motif. Members of the tumour necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) to their cytosolic tails. | P[LIVTFYHQE]Q[DET] | 13 | 4 | articles.ELM |
| LIG_TRAF3_MATH_PxP_3 | A motif that specifically binds the TRAF3 E3 ligase | P[ILVT]P(([ED][^P].)|(.[^P][ED])) | 2 | 2 | articles.ELM |
| LIG_TRAF4_MATH_1 | A TRAF4 MATH domain binding motif present in some platelet receptors | RL[^P].R | 3 | 1 | articles.ELM |
| LIG_TRAF6_MATH_1 | TRAF6 binding site. Members of the tumour necrosis factor receptor (TNFR) superfamily initiate intracellular signalling by recruiting the C-domains of the TNFR-associated factors (TRAFs) using motifs in their cytoplasmic tails. | ..P[^P]E[^P].[FYWHDE]. | 34 | 5 | articles.ELM |
| LIG_Trf4_IWRxY_1 | TRAMP complex subunits Air1/2 bind subunits Trf4/Trf5 through an extended interaction surface, involving the IWRxY motif. | [IVL]WR.Y | 4 | 1 | articles.ELM |
| LIG_TRFH_1 | TRF1 and TRF2 both bind to another shelterin protein: TIN2. The TRF1-TIN2 interaction was mediated by a short motif in the N-Ter of TIN2. TIN2 connects TRF1 to TRF2; this link contributes to the stabilization of TRF2 on telomeres. | [FY].L.P | 3 | 2 | articles.ELM |
| LIG_TYR_ITAM | ITAM (immunoreceptor tyrosine-based activatory motif). ITAM consists of partially conserved short sequence of amino acid found in the cytoplasmatic tail of antigen and Fc receptors. |
[DEN]..(Y)..[LI].{6,12}(Y)..[LI] | 7 | 1 | articles.ELM |
| LIG_TYR_ITIM | ITIM (immunoreceptor tyrosine-based inhibitory motif). Phosphorylation of the ITIM motif, found in the cytoplasmic tail of some inhibitory receptors (KIRs) that bind MHC Class I, leads to the recruitment and activation of a protein tyrosine phosphatase. | [ILV].(Y)..[ILV] | 7 | 0 | articles.ELM |
| LIG_TYR_ITSM | ITSM (immunoreceptor tyrosine-based switch motif). This motif is present in the cytoplasmic region of the CD150 subfamily within the CD2 family and it enables these receptors to bind to and to be regulated by SH2 adaptor molecules, as SH2DIA. | ..T.(Y)..[IV] | 12 | 0 | articles.ELM |
| LIG_UBA3_1 | UBA3 adenylation domain binding motif variant based on the UBE2M and UBE2F interactions. | [ILM][ILMF].{1,2}[ILM].{0,4}K | 2 | 0 | articles.ELM |
| LIG_UFM1_UFIM_1 | UFIM is a motif present in the E1 enzyme UBA5 required to bind ubiquitin-like protein UFM1. UFIM overlaps with a LIR motif binding LC3/GABARAP family proteins. | [ND].WGI.[LIV][VMLI].{0,1}[ED] | 1 | 1 | articles.ELM |
| LIG_ULM_U2AF65_1 | Pattern encompassing the ULMs in SF1 and SAP155 which bind to the UHM of U2AF65 | [KR]{1,4}[KR].[KR]W. | 8 | 3 | articles.ELM |
| LIG_VCP_SHPBox_1 | The SHP box motif is a VCP-binding ligand present in some adaptors that bind to the C-terminal NTD subdomain of VCP. | .((F.)|(W))G.G[^P].L. | 17 | 2 | articles.ELM |
| LIG_VCP_VBM_3 | The VCP Binding Motif (VBM) binds to the N-terminal domain of VCP and is present in some of its cofactors. | [ILMV]R[^PG]{2}R[^PG]{3}[FL][ED] | 3 | 1 | articles.ELM |
| LIG_VCP_VIM_2 | VCP Interacting Motif (VIM) binds to the N-terminal domain of VCP and is present in various cofactors. | [RKQ][^P]{1,3}[AG][^P]AA[^P]{1,2}R[^P] | 9 | 1 | articles.ELM |
| LIG_Vh1_VBS_1 | An amphipathic alpha-helix recognized by the head domain of vinculin that is required for vinculin activation and actin filament attachment. | [VMILF][MILVFYHPA][^P][TASKHCV][AVSC][^P][^P][ILVMT][^P][^P][^P][LMTVI][^P][^P][LMVCT][ILVMCA][^P][^P][AIVLMTC] | 15 | 10 | articles.ELM |
| LIG_WD40_WDR5_VDV_1 | This WDR5-binding motif binds to a cleft between blades 5 and 6 of the WD40 repeat domain of WDR5, opposite of the Win motif-binding site, to mediate assembly of histone modification complexes. | [ED].{0,3}[VIL]D[VI] | 3 | 3 | articles.ELM |
| LIG_WD40_WDR5_VDV_2 | Fungi-specific variant of the WDR5-binding motif that binds to a cleft between blades 5 and 6 of the WD40 repeat domain of WDR5, opposite of the Win motif-binding site, to mediate assembly of histone modification complexes. | [EDSTY].{0,4}[VIPLA][TSDEKR][ILVA] | 2 | 0 | articles.ELM |
| LIG_WD40_WDR5_WIN_1 | Known as the Win (WDR5 interaction) motif, this peptide binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. | [SCA]AR[STCA][EQR][PGILVM][HYFQNKRLVI] | 7 | 7 | articles.ELM |
| LIG_WD40_WDR5_WIN_2 | Generalised metazoan variant of the Win (WDR5 interaction) motif, which in Vertebrates binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. | [STCA][CSAGV]R[STCAV][EQR][PGALV][LFYHRK] | 4 | 1 | articles.ELM |
| LIG_WD40_WDR5_WIN_3 | Generalised fungal variant of the Win (WDR5 interaction) motif, which in Vertebrates binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. | [SCA][AFWHSV][KR][TAS][DEQR][GP][RKYFWIVAM]..[IVM] | 3 | 0 | articles.ELM |
| LIG_WH1 | LIG_WH1 is the WIP sequence motif binding to the WH1 domains of WASP and N-WASP. | ES[RK][FY].F[HR][PST][IVLM][DES][DE] | 3 | 0 | articles.ELM |
| LIG_WRC_WIRS_1 | WRC interacting receptor sequence (WIRS) is a highly conserved and widespread interaction motif that is employed by diverse membrane proteins to recruit the WRC to initiate the dynamic rearrangements of the actin cytoskeleton. | [FYILMV].[TS]F(G|[^P]). | 22 | 0 | articles.ELM |
| LIG_WRPW_1 | The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_1 is based on the C-terminus located motifs found in the Hairy and Runt family proteins. | [WFY]RP[WFY].{0,7}$ | 20 | 0 | articles.ELM |
| LIG_WRPW_2 | The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_2 is not restricted to the C-terminus (in contrast to LIG_WRPW_1). | [WFY][KR]P[WFY] | 2 | 0 | articles.ELM |
| LIG_WW_1 | PPXY is the motif recognized by WW domains of Group I | PP.Y | 29 | 3 | articles.ELM |
| LIG_WW_2 | PPLP is the motif recognized by WW domains of Group II | PPLP | 3 | 0 | articles.ELM |
| LIG_WW_3 | WW domain of group III binding motif | .PPR. | 1 | 0 | articles.ELM |
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Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement