The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
export 165 classes as:
ELM IdentifierDescriptionRegExInstancesInstances in PDBArticles.ELM
DEG_CRL4_CDT2_1 This degron overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. [NQ]{0,1}..[ILMV][ST][DEN][FY][FY].{2,3}[KR]{2,3}[^DE] 6 0 articles.ELM
DEG_CRL4_CDT2_2 This degron, occurring in non-Vertebrates, overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. [NQ]{0,1}..[ILMV]T[DEN][HMFY][FMY].{2,3}[KR]{2,3}[^DE] 1 0 articles.ELM
LIG_14-3-3_CanoR_1 Canonical Arg-containing phospho-motif mediating a strong interaction with 14-3-3 proteins. R[^DE]{0,2}[^DEPG]([ST])(([FWYLMV].)|([^PRIKGN]P)|([^PRIKGN].{2,4}[VILMFWYP])) 65 16 articles.ELM
LIG_14-3-3_ChREBP_3 14-3-3 protein binding to a nonphosphorylated helical peptide in ChREBP is promoted by Adenosine monophosphate. IR[^P][^P]N[^P][^P]WR[^P]W[YFH][ITML][^P]Y[IVL] 1 1 articles.ELM
LIG_14-3-3_CterR_2 C-terminal Arg-containing phospho-motif mediating a strong interaction with 14-3-3 proteins. R[^DE]{0,2}[^DEPG]([ST])[^P]{0,1}$ 6 1 articles.ELM
LIG_Actin_RPEL_3 RPEL motif, present in proteins in several repeats, mediates binding to the hydrophobic cleft created by subdomains 1 and 3 of G-actin. [IL]..[^P][^P][^P][^P]R.....[IL]..[^P][^P][ILV][ILM] 13 3 articles.ELM
LIG_Actin_WH2_1 WH2 is a motif of variable length (16-19 amino acids) binding to the hydrophobic cleft formed by actin's subdomains 1 and 3. At the N-terminus it forms an alpha-helix followed by a flexible loop stabilised upon actin binding. R..[ILVMF][ILMVF][^P][^P][ILVM].{4,7}L(([KR].)|(NK))[VATI] 9 4 articles.ELM
LIG_Actin_WH2_2 The WH2 motif is of variable length (16-19 amino acids) binding to the hydrophobic cleft formed by actin's subdomains 1 and 3. At the N-terminus it forms an alpha-helix followed by a flexible loop stabilised upon actin binding. [^R]..((.[ILMVF])|([ILMVF].))[^P][^P][ILVM].{4,7}L(([KR].)|(NK))[VATIGS] 17 2 articles.ELM
LIG_ANK_PxLPxL_1 The consensus PxLPxI/L motif, which can be found in diverse proteins, binds to the ankyrin repeat domains of ANKRA2 and its close paralog RFXANK. P.LP.[IL].{1,3}[VLF] 10 5 articles.ELM
LIG_AP2alpha_1 FxDxF motif responsible for the binding of accessory endocytic proteins to the appendage of the alpha-subunit of adaptor protein complex AP-2 F.D.F 11 2 articles.ELM
LIG_AP2alpha_2 DPF/W motif binds alpha and beta subunits of AP2 adaptor complex. DP[FW] 54 2 articles.ELM
LIG_APCC_ABBA_1 Amphipathic motif that is involved in APC/C inhibition by binding of CDH1/CDC20. In metazoan cyclin A, the motif also acts as a degron, enabling the cyclin's degradation in prometaphase. [ILVMF].[ILMVP][FHY].[DE] 11 1 articles.ELM
LIG_APCC_ABBAyCdc20_2 Amphipathic motif that binds to yeast Cdc20 and acts as an APC/C degron enabling cyclin Clb5 degradation during mitosis. [KR]..[ILVM][FHY].[DE] 2 0 articles.ELM
LIG_APCC_Cbox_1 Motif in APC/C co-activators that mediates binding to the APC/C core, possibly the catalytic Apc2 subunit. This first variant defines the motif in APC/C co-activators from Eukaryota except Fungi and Amoebozoa. [DE]R[YFH][ILFVM][PAG].R 2 0 articles.ELM
LIG_APCC_Cbox_2 Motif in APC/C co-activators that mediates binding to the APC/C core, possibly the catalytic Apc2 subunit. This second variant defines the motif in APC/C co-activators from Fungi and Amoebozoa. DR[YFH][ILFVM][PA].. 3 0 articles.ELM
LIG_AP_GAE_1 The acidic Phe motif mediates the interaction between a set of accessory proteins and the gamma-ear domain (GAE) of GGAs and AP-1. Proposed roles: in clathrin localization and assembly on TGN/endosome membranes and in traffic between the TGN and endosome. [DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD] 11 0 articles.ELM
LIG_ARL_BART_1 The ligand motif present at the N-terminus of ARL2 and ARL3 proteins ensures GTD-dependent binding to BART and BARTL1 ^..LL[^P]IL[^P][^P][LM] 2 2 articles.ELM
LIG_BH_BH3_1 The BH3 motif is found in pro-apoptotic proteins and interacts with BH domains of the anti-apoptotic Bcl-2 family members to regulate apoptosis. ....[LIFVYMTE][ASGC][^P]{2}L[^P]{2}[IVMTL][GACS][D][^P][FVLMI]. 19 8 articles.ELM
LIG_BIR_II_1 These IBMs are found in pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type II BIR domains. ^M{0,1}[AS]... 0 0 articles.ELM
LIG_BIR_III_1 These IBMs are found in pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type III BIR domains. ^M{0,1}A.P. 1 0 articles.ELM
LIG_BIR_III_2 These IBMs are found at the N-terminal regions of caspase subunits where they mediate the inhibition of activated caspases by binding to conserved surface grooves on type III BIR domains of Inhibitor of Apoptosis Proteins (IAPs). DA.P. 3 1 articles.ELM
LIG_BIR_III_3 These IBMs are found in arthropodal pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type III BIR domains of arthropodal IAPs. ^M{0,1}A.[AP]. 4 3 articles.ELM
LIG_BIR_III_4 These IBMs are found in the N-terminal regions of arthropodal caspase subunits where they mediate the inhibition of activated caspases by binding to conserved surface grooves on type III BIR domains of Inhibitor of Apoptosis Proteins (IAPs). DA.G. 2 0 articles.ELM
LIG_BRCT_BRCA1_1 Phosphopeptide motif which directly interacts with the BRCT (carboxy-terminal) domain of the Breast Cancer Gene BRCA1 with low affinity .(S)..F 5 3 articles.ELM
LIG_BRCT_BRCA1_2 Phosphopeptide motif which directly interacts with the BRCT (carboxy-terminal) domain of the Breast Cancer Gene BRCA1 with high affinity. .(S)..F.K 1 1 articles.ELM
LIG_BRCT_MDC1_1 Phosphopeptide motif which is specifically recognized by the BRCT (Carboxy-terminal) repeats of MDC1 .(S)..Y$ 1 1 articles.ELM
LIG_CaM_IQ_9 Helical peptide motif responsible for Ca2+-independent binding of the CaM . The motif is manly characterized by a hydrophobic residue at position 1, a highly conserved Gln at position 2, basic charges at positions 6 and 11, and a variable Gly at position 7 [ACLIVTM][^P][^P][ILVMFCT]Q[^P][^P][^P][RK][^P]{4,5}[RKQ][^P][^P] 75 10 articles.ELM
LIG_CaMK_CASK_1 Motif that mediates binding to the calmodulin-dependent protein kinase (CaMK) domain of the peripheral plasma membrane protein CASK/Lin2. ((SP)|([ED].{0,1}))[IV]W[IVL].R 6 0 articles.ELM
LIG_CaM_NSCaTE_8 Short motif recognized by CaM that is only present in the Cav1.2 and Cav1.3 L-type calcium channels. W[^P][^P][^P][IL][^P][AGS][AT] 3 0 articles.ELM
LIG_CAP-Gly_1 Short, acidic and aromatic carboxy terminal sequence found in a small group of microtubule-associated-proteins. The EEY/F$ motif is highly conserved and so far limited to a few known proteins, alpha-tubulin, EB proteins and CLIP170. [ED].{0,2}[ED].{0,2}[EDQ].{0,1}[YF]$ 3 3 articles.ELM
LIG_CAP-Gly_2 Short, partly aromatic carboxy terminal sequence found in the SLAIN group of microtubule-associated-proteins. .W[RK][DE]GCY$ 1 1 articles.ELM
LIG_CID_NIM_1 The NIM motif in Trf4 interacts with the CTD-interacting domain (CID) of Nrd1 [DE][DEN][DEN]D[GDN]Y.P.. 1 1 articles.ELM
LIG_Clathr_ClatBox_1 Clathrin box motif found on cargo adaptor proteins, it interacts with the beta propeller structure located at the N-terminus of Clathrin heavy chain. L[IVLMF].[IVLMF][DE] 18 3 articles.ELM
LIG_Clathr_ClatBox_2 Clathrin box motif found on cargo adaptor proteins, it mediates binding to the N-terminal beta propeller of clathrin heavy chain. Also called W box, it is found in the central region of Amphiphysins where it coexists with a "classical" clathrin box. .[NP]W[DES].W 2 1 articles.ELM
LIG_CNOT1_NIM_1 The CNOT1-interacting motif (NIM) found in Nanos proteins mediates recruitment of the CCR4-NOT deadenylase complex. [FY][^P].[WFY][^P]DY..L 10 1 articles.ELM
LIG_CORNRBOX The corepressor nuclear receptor box motif confers binding to nuclear receptors. L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] 4 3 articles.ELM
LIG_CSK_EPIYA_1 Csk Src Homology 2 (SH2) domain binding EPIYA motif EP[IL]Y[TAG] 20 0 articles.ELM
LIG_CSL_BTD_1 The motif mediates the interaction between a Notch-like protein and the transcription factor CSL by placing two amino acids (W and P) into a hydrophobic pocket of the BTD domain of CSL. [AFILMPTVW]W[FHILMPSTVW]P 18 2 articles.ELM
LIG_CtBP_PxDLS_1 The PxDLS motif interacts with the NAD-dependent repressor CtBP proteins. (P[LVIPME][DENS][LM][VASTRG])|(G[LVIPME][DENS][LM][VASTRG]((K)|(.[KR]))) 32 0 articles.ELM
LIG_DCNL_PONY_1 DCNL PONY domain binding motif variant based on the UBE2M and UBE2F interactions. ^M[MIL].[MIL] 2 0 articles.ELM
LIG_deltaCOP1_diTrp_1 Tryptophan-based motifs enable targeting of the tethering and (dis)assembly factors to the C-terminal mu homology domain (MHD) of the coatomer subunit delta, delta-COP. [DE]{1,3}.{0,2}W.{1,6}[WF] 5 2 articles.ELM
LIG_Dynein_DLC8_1 The [KR]xTQT motif interacts with the common target-accepting grooves of 8kDa Dynein Light Chain dimer. [^P].[KR].TQT 9 4 articles.ELM
LIG_EABR_CEP55_1 This proline-rich motif binds to the EABR domain of Cep55 and is involved in both cytokinesis of somatic cells and intercellular bridge formation in differentiating germ cells. .A.GPP.{2,3}Y. 6 1 articles.ELM
LIG_EF_ALG2_ABM_1 This isoform-specific ALG-2-binding motif binds to the EF hand domains of the proapoptotic Ca2+-binding ALG-2 protein in a Ca2+-dependent manner. P[PG]{0,1}YP.{1,6}Y[QS]{0,1}P 9 1 articles.ELM
LIG_EF_ALG2_ABM_2 This isoform-unspecific ALG-2-binding motif binds to the EF hand domains of the proapoptotic Ca2+-binding ALG-2 protein in a Ca2+-dependent manner. P.P.{0,1}GF 3 0 articles.ELM
LIG_EH_1 NPF motif interacting with EH domains, usually during regulation of endocytotic processes .NPF. 88 3 articles.ELM
LIG_EH1_1 The engrailed homology domain 1 motif is found in homeodomain containing active repressors and other transcription families, and allows for the recruitment of Groucho/TLE corepressors. .[FYH].[IVM][^WFYP][^WFYP][ILM][ILMV]. 11 1 articles.ELM
LIG_eIF4E_1 Motif binding to the dorsal surface of eIF4E. Y....L[VILMF] 13 0 articles.ELM
LIG_eIF4E_2 Atypical variant of eIF4E motif. Y.PP.[ILMV]R 5 0 articles.ELM
LIG_EVH1_1 Proline-rich motif binding to signal transduction class I EVH1 domains. ([FYWL]P.PP)|([FYWL]PP[ALIVTFY]P) 19 3 articles.ELM
LIG_EVH1_2 Proline-rich motif binding to signal transduction class II EVH1 domains. PP..F 8 1 articles.ELM
LIG_EVH1_3 A proline-rich motif binding to EVH1/WH1 domains of WASP and N-WASP proteins. [FY].[FW].....[LMVIF]P.P[DE] 3 1 articles.ELM
LIG_FAT_LD_1 The paxillin LD motif is recognized by FAK and other focal adhesion proteins mainly involved in cytoskeletal regulation [LV][DE][^P][LM][LM][^P][^P]L[^P] 4 2 articles.ELM
LIG_FHA_1 Phosphothreonine motif binding a subset of FHA domains that show a preference for a large aliphatic amino acid at the pT+3 position. ..(T)..[ILV]. 6 3 articles.ELM
LIG_FHA_2 Phosphothreonine motif binding a subset of FHA domains that have a preference for an acidic amino acid at the pT+3 position. ..(T)..[DE]. 6 2 articles.ELM
LIG_FXI_DFP_1 The DFP motif enables binding to the 2nd apple domain of coagulation factor XI (FXI) and plasma kallikrein heavy chain. [FYWHIL].DF[PD] 5 2 articles.ELM
LIG_FZD_DVL_PDZ A short internal motif near the C-terminus of Frizzleds, which interacts with the PDZ domain of DVL in Wnt pathway. W.{0,1}[VIL].[ST].KA{0,1}T...W 9 0 articles.ELM
LIG_G3BP_FGDF_1 The FGDF motif binds to a hydrophobic binding cleft within the N-terminal NTF2-like domain of the stress granule protein G3BP. [FYLIMV].FG[DES]F 9 0 articles.ELM
LIG_GBD_Chelix_1 Amphipatic alpha helix that binds the GTPase-binding domain (GBD) in WASP and N-WASP. [ILV][VA][^P][^P][LI][^P][^P][^P][LM] 12 3 articles.ELM
LIG_GLEBS_BUB3_1 Gle2-binding-sequence motif [EN][FYLW][NSQ].EE[ILMVF][^P][LIVMFA] 5 2 articles.ELM
LIG_GSK3_LRP6_1 PPPSP motif present on the cytosolic tails of the transmembrane receptors LRP5 and LRP6, responsible for GSK3 binding and inhibition when phosphorylated. (([CP]PP)|(PP[TP]))[ST]P[^P][TS]{0,1} 8 0 articles.ELM
LIG_GYF LIG_GYF is a proline-rich sequence specifically recognized by GYF domains [QHR].{0,1}P[PL]PP[GS]H[RH] 3 1 articles.ELM
LIG_HCF-1_HBM_1 The DHxY Host Cell Factor-1 binding motif (HBM) interacts with the N-terminal kelch propeller domain of the cell cycle regulator HCF-1 [DE]H.Y 17 0 articles.ELM
LIG_HOMEOBOX The YPWM motif confers binding to the PBX homeobox domain [FY][DEP]WM 16 1 articles.ELM
LIG_HP1_1 Ligand to interface formed by dimerisation of two chromoshadow domains in HP1 proteins. P[MVLIRWY]V[MVLIAS][LM] 9 1 articles.ELM
LIG_IBAR_NPY_1 A short NPY motif present in the bacterial effector protein Tir binds the I-BAR domain and is involved in actin polymerization NPY 7 1 articles.ELM
LIG_IBS_1 Integrins are major collagen receptors on the surface of eukaryotic cells. This consensus sequence is present in some alpha chains of different collagen types (e.g. alpha 1 chain of type I, II, V and alpha 2 chain of collagen type I and VIII). G[FL]PGER..G 0 0 articles.ELM
LIG_Integrin_isoDGR_1 NGR motif is present in proteins of extracellular matrix which upon deamidation forms a biologically active isoDGR motif that binds to various members of integrin family. NGR 8 0 articles.ELM
LIG_IRF3_LxIS_1 A binding site for IRF-3 protein present in various innate adaptor proteins, IRF-3 itself and rotaviral NSP1 which triggers the innate immune responsive pathways [VILPF].{1,3}L.I(S) 7 5 articles.ELM
LIG_KEPE_1 Short length variant of the KEPE motif which is found superposed on some SUMO sites [VILMFT]K.EP.[DE] 5 0 articles.ELM
LIG_KEPE_2 Medium length variant of the KEPE motif which is found superposed on some SUMO sites [VILMFT]K.EP.{2,3}[DE] 12 0 articles.ELM
LIG_KEPE_3 Long length variant of the KEPE motif which is found superposed on some SUMO sites [VILMFT]K.EP....[DE] 4 0 articles.ELM
LIG_KLC1_WD_1 This short WD or WE motif is found in cargo proteins and mediates kinesin-1-dependent microtubule transport by binding to the KLC TPR region. [LMTAFSRI][^KRG]W[DE].{3,5}[LIVMFPA] 22 1 articles.ELM
LIG_LIR_Apic_2 Apicomplexa specific variant of the canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. [EDST].{0,2}[WFY]..P 1 1 articles.ELM
LIG_LIR_Gen_1 Canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. [EDST].{0,2}[WFY][^RKPG][^PG][ILV] 21 7 articles.ELM
LIG_LIR_LC3C_4 Non-canonical variant of the LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. [EDST].{0,2}LVV 1 1 articles.ELM
LIG_LIR_Nem_3 Nematode-specific variant of the canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. [EDST].{0,2}[WFY]..[ILVFY] 1 0 articles.ELM
LIG_LRP6_Inhibitor_1 Short motif present in extracellular of some Wnt antagonists recognized by the N-terminal β-propeller domain of LRP5/6 and thus inhibits the Wnt pathway. ([VILA]..N.I[RK])|([VILA].PN.IG.{0,6}[RK]) 3 2 articles.ELM
LIG_LYPXL_L_2 The long version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting. [LM]YP...[LI][^P][^P][LI] 3 2 articles.ELM
LIG_LYPXL_S_1 The short version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting. [LM]YP.[LI] 16 1 articles.ELM
LIG_MAD2 Mad2 binding motif [KR][IV][LV].....P 6 1 articles.ELM
LIG_MLH1_MIPbox_1 Proteins involved in DNA repair and replication employ conserved MIP-box motifs to bind the C-terminal domain of mismatch repair protein MLH1. .S.[FY][F] 6 2 articles.ELM
LIG_Mtr4_Air2_1 This motif on Air2 interacts with the DExH core of Mtr4, forming a part of the nucleus-located TRAMP complex. The motif is conserved in fungi. GRYFG 3 1 articles.ELM
LIG_Mtr4_Trf4_1 This motif on Trf4 interacts with the DExH core of Mtr4, forming a part of the nucleus-located TRAMP complex. The motif is conserved in Fungi. [LFVAIMW].{3,5}[DE][FY][IL][SAPGK][FL].{3,6}[DE]{3} 4 1 articles.ELM
LIG_Mtr4_Trf4_2 This motif on PAPD5 interacts with the DExH core of SKIV2L2, forming a part of the nucleus-located TRAMP complex. The predicted motif is conserved in Vertebrates. Q[RGQ]DF[LI][PS]L[DE] 3 0 articles.ELM
LIG_MYND_1 PxLxP motif is recognized by a subset of MYND domain containing proteins. P.L.P 6 0 articles.ELM
LIG_MYND_2 Motif that mediates the interaction between MYND domain of AML1/ETO and co-repressors SMRT and N-CoR. PP.LI 3 1 articles.ELM
LIG_MYND_3 A variant MYND binding motif found in the HSP90 co-chaperones p23 and FKBP38 interacting with PHD2 MYND domain. [LMV]P.LE 2 0 articles.ELM
LIG_NBox_RRM_1 Amino terminal region on Far Upstream Element (FUSE) binding protein (Q96AE4), which mediates the interaction with FIR in order to recruit FIR (Q9UHX1) to FUSE DNA. F..A[ILV]..A..[ILV] 2 1 articles.ELM
LIG_NRBOX The nuclear receptor box motif (LXXLL) confers binding to nuclear receptors. [^P]L[^P][^P]LL[^P] 24 5 articles.ELM
LIG_OCRL_FandH_1 The F and H motif describes a 10-13-mer peptide sequence determined by a highly conserved phenylalanine and histidine residue surrounded by hydrophobic amino acids. A complex of ASH and RhoGAP-like domain binds this motif within a hydrophobic pocket. .F[^P][^P][KRIL]H[^P][^P][YLMFH][^P]... 3 1 articles.ELM
LIG_PALB2_WD40_1 A motif present in the BRCA2 protein which binds to the WD 40 repeat (blade 4,5) domain of PALB2 which is required for the recognition of DNA double strand breaks and repair. ....WF..L 1 1 articles.ELM
LIG_PAM2_1 Peptide ligand motif that directly binds to the MLLE/PABC domain found in poly(A)-binding proteins and HYD E3 ubiquitin ligases, mainly via a common central core region and a complementary N-terminal region. ..[LFP][NS][PIVTAFL].A..(([FY].[PYLF])|(W..)). 22 6 articles.ELM
LIG_PAM2_2 Peptide ligand motif that directly binds to the MLLE/PABC domain found in poly(A)-binding proteins and HYD E3 ubiquitin ligases, mainly via a common central core region and a complementary C-terminal region. ((WPP)|([FL][PV][APQ]))EF.PG.PWKG. 4 1 articles.ELM
LIG_PCNA_APIM_2 The PCNA-binding APIM motif is found in proteins involved in DNA repair and cell cycle control [MLIV].[KR][FY][MLIVF][LIV][KR] 2 1 articles.ELM
LIG_PCNA_PIPBox_1 The PCNA binding motifs include the PIP Box and the APIM motif, and are found in proteins involved in DNA replication, repair, methylation and cell cycle control. [QM].[^FHWY][LIVM][^P][^PFWYMLIV](([FYHL][FYW])|([FYH][FYWL])).. 19 10 articles.ELM
LIG_PCNA_yPIPBox_3 The PCNA binding motifs include the PIP Box, PIP degron and the APIM motif, and are found in proteins involved in DNA replication, repair, methylation and cell cycle control. This is the variant for the yeast PIPbox ([KR].{0,6}[QN].[^FHWY][LIVM][^P][^PFWYMLIV][FYLMWV][FYLMWVI])|([QN].[^FHWY][LIVM][^P][^PFWYMLIV][FYLMWV][FYLMWVI].{0,6}[KR]) 12 2 articles.ELM
LIG_PDZ_Class_1 The C-terminal class 1 PDZ-binding motif is classically represented by a pattern like (ST)X(VIL)* ...[ST].[ACVILF]$ 52 24 articles.ELM
LIG_PDZ_Class_2 The C-terminal class 2 PDZ-binding motif is classically represented by a pattern such as (VYF)X(VIL)* ...[VLIFY].[ACVILF]$ 13 8 articles.ELM
LIG_PDZ_Class_3 The C-terminal class 3 PDZ-binding motif is classically represented by a pattern such as (DE)X(VIL)* ...[DE].[ACVILF]$ 1 1 articles.ELM
LIG_PDZ_Wminus1_1 The C-terminal Trp-1 PDZ-binding motif is represented by a pattern like W(ACGILV)$ .W[ACGILV]$ 27 3 articles.ELM
LIG_Pex14_1 Wxxx[FY] motifs present in N-terminal half of Pex5 bind to Pex13 and Pex14 at peroxisomal and glycosomal membranes to facilitate entrance of PTS1 cargo proteins into the organellar lumen. W...[FY] 27 1 articles.ELM
LIG_Pex14_2 Fxxx[WF] motifs are present in Pex19 and S. cerevisiae Pex5 cytosolic receptors that bind to peroxisomal membrane docking member, Pex14 F...[WF] 2 0 articles.ELM
LIG_Pex14_3 Motif in Pex5 interacting with the N-terminal domain (NTD) of Pex14 LV.EF[LM] 1 1 articles.ELM
LIG_Pex14_4 Fungal motif in Pex5 interacting with the N-terminal domain of Pex14 MM[NDE][EDNAG]F[LMA] 0 0 articles.ELM
LIG_Pex3_1 LxxLLxxxLxxF motif is located in N-terminus of Pex19 receptors that are responsible for docking to Pex3 docking factor at cis side of peroxisomal membrane. L..LL...L..F 1 0 articles.ELM
LIG_PROFILIN_1 The polyproline profilin-binding motif is found in regulators of actin cytoskeleton. PPP[PA]P((P[LGP])|([LG]P)) 16 4 articles.ELM
LIG_PTAP_UEV_1 PTAP motif binds the N-terminal UEV domain of Tsg101. .P[TS]AP. 25 2 articles.ELM
LIG_PTB_Apo_2 These phosphorylation-independent motifs bind to Dab-like PTB domains. Binding is not driven by contacts at the 0 or FY position, but instead is dependent upon the large number of hydrophobic and hydrogen bond contacts between motif and domain. (.[^P].NP.[FY].)|(.[ILVMFY].N..[FY].) 19 7 articles.ELM
LIG_PTB_Phospho_1 This phosphorylation-dependent motif binds to Shc-like and IRS-like PTB domains. The pTyr is positioned within a highly basic-charged anchoring pocket. A hydrophobic residue -5 (compared to pY) increases the affinity of the interaction. (.[^P].NP.(Y))|(.[ILVMFY].N..(Y)) 17 6 articles.ELM
LIG_Rb_LxCxE_1 Interacts with the Retinoblastoma protein ([DEST]|^).{0,4}[LI].C.E.{1,4}[FLMIVAWPHY].{0,8}([DEST]|$) 45 9 articles.ELM
LIG_Rb_pABgroove_1 The LxxLFD motif binds in a deep groove between pocket A and pocket B of the Retinoblastoma protein ..[LIMV]..[LM][FY]D. 3 2 articles.ELM
LIG_REV1ctd_RIR_1 Several DNA repair proteins interact with the C-terminal domain of the Rev1 translesion synthesis scaffold through the Rev1-Interacting Region RIR motif that is centred around two neighbouring Phe residues.
..FF[^P]{0,2}[KR]{1,2}[^P]{0,4} 10 4 articles.ELM
LIG_RGD The RGD motif can be found in many proteins of the extracellular matrix and it is recognized by different members of the integrin family. The structure of the tenth type III module of fibronectin has shown that the RGD motif lies on an exposed flexible lo RGD 25 2 articles.ELM
LIG_RPA_C_Fungi Fungi version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. [^P][MIALVF][^P][^P][NSHRA]R[^P][^P][ASV][^P][^P][RKLIA][RQLIVA] 1 0 articles.ELM
LIG_RPA_C_Insects Insect version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. [^P][MIAL][^P][^P][NKS][KRLQH][^P][^P]A[^P][^P][RKLI][RKL][^P][^P][KR] 0 0 articles.ELM
LIG_RPA_C_Plants Plant version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. R[MIVAS][^P][^P][NQ][KRL][^P][^P]A[^P][^P][RK] 0 0 articles.ELM
LIG_RPA_C_Vert The RPA interacting motif is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. [KRS]I[^P][^P][NK][KR][^P][^P]A[^P][^P][RKL][RKL][^P][^P][RK] 4 2 articles.ELM
LIG_RRM_PRI_1 The PTB RRM2 Interacting (PRI) motif is found in some splicing regulators, possibly only in the chordate lineage. As part of splicing complex regulation, it interacts with the 2nd RNA binding domain (RRM) of PTB, the polypyrimidine tract binding protein. .[ILVM]LG..P. 3 0 articles.ELM
LIG_Rrp6Rrp47_Mtr4_1 The motif enables the interaction of Mtr4 like helicases with the Rrp6-Rrp47 heterodimer and thus the formation of the exosome binding complex. [ED]LF[^P][VC]F.{0,1}[ED] 5 1 articles.ELM
LIG_SH2_CRK CRK family SH2 domain binding motif. (Y)[^EPILVFYW][^HDEW][PLIV][^DEW] 36 1 articles.ELM
LIG_SH2_GRB2like GRB2-like Src Homology 2 (SH2) domains binding motif (Y)([EDST]|[MLIVAFYHQW])N. 35 10 articles.ELM
LIG_SH2_NCK_1 NCK Src Homology 2 (SH2) domain binding motif (Y)[DESTNA][^GWFY][VPAI][DENQSTAGYFP] 17 1 articles.ELM
LIG_SH2_PTP2 SH-PTP2 and phospholipase C-gamma Src Homology 2 (SH2) domains binding motif. (Y)[IV].[VILP] 1 0 articles.ELM
LIG_SH2_SRC Src-family Src Homology 2 (SH2) domains binding motif. (Y)[QDEVAIL][DENPYHI][IPVGAHS] 24 1 articles.ELM
LIG_SH2_STAP1 STAP1 Src Homology 2 (SH2) domain Class 2 binding motif (Y)[DESTA][^GP][^GP][ILVFMWYA] 22 1 articles.ELM
LIG_SH2_STAT3 YXXQ motif found in the cytoplasmic region of cytokine receptors that bind STAT3 SH2 domain. (Y)..Q 9 0 articles.ELM
LIG_SH2_STAT5 STAT5 Src Homology 2 (SH2) domain binding motif. (Y)[VLTFIC].. 19 0 articles.ELM
LIG_SH2_STAT6 STAT6 Src Homology 2 (SH2) domain binding motif. G(Y)[KQ].F 1 0 articles.ELM
LIG_SH3_1 This is the motif recognized by class I SH3 domains [RKY]..P..P 8 0 articles.ELM
LIG_SH3_2 This is the motif recognized by class II SH3 domains P..P.[KR] 19 6 articles.ELM
LIG_SH3_3 This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity ...[PV]..P 26 1 articles.ELM
LIG_SH3_4 This is the motif recognized by those SH3 domains with a non-canonical class II recognition specificity KP..[QK]... 2 0 articles.ELM
LIG_SH3_5 PXXDY motif recognized by some SH3 domains P..DY 3 0 articles.ELM
LIG_Sin3_1 Motif interacts with PAH2 domain in the Sin3 scaffold protein. [LIV]..[LM]L.AA.[FY][LI] 4 2 articles.ELM
LIG_Sin3_2 Motif interacts with PAH2 domain in the Sin3 scaffold protein (sp-1 like). [FHYM].A[AV].[VAC]L[MV].[MI] 3 0 articles.ELM
LIG_Sin3_3 Motif interacts with PAH2 domain in the Sin3 scaffold protein (not mad or sp-1 like). [FA].[LA][LV][LVI]..[AM] 2 0 articles.ELM
LIG_SPRY_1 Peptide motif binding to the members of the SSB (or SPSB) family (SPRY domain- and SOCS box-containing protein) [ED][LIV]NNN[^P] 2 2 articles.ELM
LIG_SUFU_1 A hydrophobic motif in GLI transcription factors required for binding to SUFU protein, which inhibits their activity and hence negatively regulates hedgehog signalling. [SV][CY]GH[LIF][LAST][GAIV]. 5 2 articles.ELM
LIG_SUMO_SIM_anti_2 Motif for the antiparallel beta augmentation mode of non-covalent binding to SUMO protein. [DEST]{1,10}.{0,1}[VIL][DESTVILMA][VIL][VILM].[DEST]{0,5} 17 2 articles.ELM
LIG_SUMO_SIM_par_1 Motif for the parallel beta augmentation mode of non-covalent binding to SUMO protein. [DEST]{0,5}.[VILPTM][VIL][DESTVILMA][VIL].{0,1}[DEST]{1,10} 33 4 articles.ELM
LIG_SxIP_EBH_1 SxIP motifs bind to EBH domains. ([KR][^ED]{0,5}[ST].IP[^ED]{5,5})|([^ED]{5,5}[ST].IP[^ED]{0,5}[KR]) 9 1 articles.ELM
LIG_TPR Ligands of the TPR (tetratricopeptide repeat motif) domains are EEVD motifs, C-terminal sequences highly conserved in all eukaryotic members of the Hsp70 and Hsp90 families. EEVD$ 9 2 articles.ELM
LIG_TRAF2_1 Major TRAF2-binding consensus motif. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmic tails. [PSAT].[QE]E 14 6 articles.ELM
LIG_TRAF2_2 Minor TRAF2-binding consensus motif. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmic tails. P.Q..D 1 1 articles.ELM
LIG_TRAF6 TRAF6 binding site. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmatic tails. ..P.E..[FYWHDE]. 20 0 articles.ELM
LIG_TRFH_1 TRF1 and TRF2 both bind to another shelterin protein: TIN2. The TRF1-TIN2 interaction was mediated by a short motif in the N-Ter of TIN2. TIN2 connects TRF1 to TRF2; this link contributes to the stabilization of TRF2 on telomeres. [FY].L.P 3 2 articles.ELM
LIG_TYR_ITAM ITAM (immunoreceptor tyrosine-based activatory motif).
ITAM consists of partially conserved short sequence of amino acid found in the cytoplasmatic tail of antigen and Fc receptors.
[DEN]..(Y)..[LI].{6,12}(Y)..[LI] 7 1 articles.ELM
LIG_TYR_ITIM ITIM (immunoreceptor tyrosine-based inhibitory motif). Phosphorylation of the ITIM motif, found in the cytoplasmic tail of some inhibitory receptors (KIRs) that bind MHC Class I, leads to the recruitment and activation of a protein tyrosine phosphatase. [ILV].(Y)..[ILV] 7 0 articles.ELM
LIG_TYR_ITSM ITSM (immunoreceptor tyrosine-based switch motif). This motif is present in the cytoplasmic region of the CD150 subfamily within the CD2 family and it enables these receptors to bind to and to be regulated by SH2 adaptor molecules, as SH2DIA. ..T.(Y)..[IV] 12 0 articles.ELM
LIG_UBA3_1 UBA3 adenylation domain binding motif variant based on the UBE2M and UBE2F interactions. [ILM][ILMF].{1,2}[ILM].{0,4}K 2 0 articles.ELM
LIG_UFM1_UFIM_1 UFIM is a motif present in the E1 enzyme UBA5 required to bind ubiquitin-like protein UFM1. UFIM overlaps with a LIR motif binding LC3/GABARAP family proteins. [ND].WGI.[LIV][VMLI].{0,1}[ED] 1 1 articles.ELM
LIG_ULM_U2AF65_1 Pattern encompassing the ULMs in SF1 and SAP155 which bind to the UHM of U2AF65 [KR]{1,4}[KR].[KR]W. 8 3 articles.ELM
LIG_Vh1_VBS_1 An amphipathic alpha-helix recognized by the head domain of vinculin that is required for vinculin activation and actin filament attachment. [VMILF][MILVFYHPA][^P][TASKHCV][AVSC][^P][^P][ILVMT][^P][^P][^P][LMTVI][^P][^P][LMVCT][ILVMCA][^P][^P][AIVLMTC] 15 10 articles.ELM
LIG_WD40_WDR5_VDV_1 This WDR5-binding motif binds to a cleft between blades 5 and 6 of the WD40 repeat domain of WDR5, opposite of the Win motif-binding site, to mediate assembly of histone modification complexes. [ED].{0,3}[VIL]D[VI] 3 3 articles.ELM
LIG_WD40_WDR5_VDV_2 Fungi-specific variant of the WDR5-binding motif that binds to a cleft between blades 5 and 6 of the WD40 repeat domain of WDR5, opposite of the Win motif-binding site, to mediate assembly of histone modification complexes. [EDSTY].{0,4}[VIPLA][TSDEKR][ILVA] 2 0 articles.ELM
LIG_WD40_WDR5_WIN_1 Known as the Win (WDR5 interaction) motif, this peptide binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. [SCA]AR[STCA][EQR][PGILVM][HYFQNKRLVI] 7 7 articles.ELM
LIG_WD40_WDR5_WIN_2 Generalised metazoan variant of the Win (WDR5 interaction) motif, which in Vertebrates binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. [STCA][CSAGV]R[STCAV][EQR][PGALV][LFYHRK] 4 1 articles.ELM
LIG_WD40_WDR5_WIN_3 Generalised fungal variant of the Win (WDR5 interaction) motif, which in Vertebrates binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. [SCA][AFWHSV][KR][TAS][DEQR][GP][RKYFWIVAM]..[IVM] 3 0 articles.ELM
LIG_WH1 LIG_WH1 is the WIP sequence motif binding to the WH1 domains of WASP and N-WASP. ES[RK][FY].F[HR][PST][IVLM][DES][DE] 3 0 articles.ELM
LIG_WRPW_1 The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_1 is based on the C-terminus located motifs found in the Hairy and Runt family proteins. [WFY]RP[WFY].{0,7}$ 20 0 articles.ELM
LIG_WRPW_2 The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_2 is not restricted to the C-terminus (in contrast to LIG_WRPW_1). [WFY][KR]P[WFY] 2 0 articles.ELM
LIG_WW_1 PPXY is the motif recognized by WW domains of Group I PP.Y 28 3 articles.ELM
LIG_WW_2 PPLP is the motif recognized by WW domains of Group II PPLP 3 0 articles.ELM
LIG_WW_3 WW domain of group III binding motif .PPR. 1 0 articles.ELM
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Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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