The Eukaryote Linear Motif resource for Functional Sites in Proteins
MOD_N-GLC_1 70
 
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Functional site class: N-glycosylation site
Functional site description: N-linked glycosylation is a co-translational process involving the transfer of a oligosaccharide chain to asparagine residue in the protein.
ELMs: MOD_N-GLC_1 MOD_N-GLC_2
Description: Generic motif for N-glycosylation. Shakin-Eshleman et al. showed that Trp, Asp, and Glu are uncommon before the Ser/Thr position. Efficient glycosylation usually occurs when ~60 residues or more separate the glycosylation acceptor site from the C-terminus
Pattern: .(N)[^P][ST].. (Probability: 0.0050178)
Present in taxons: Eukaryota
Interaction Domain:

STT3 (PF02516)
Oligosaccharyl transferase STT3 subunit
(Stochiometry: 1 : 1)

o See 156 Instances for MOD_N-GLC_1


o Abstract

N-glycosylation is the most common modification of secretory and membrane-bound proteins in eukaryotic cells.The whole process of N-glycosylation comprises more than 100 enzymes and transport proteins.

The biosynthesis of all N-linked oligosaccharides begins in the ER with a large precursor oligosaccharid. The structure of this oligosaccharide [(Glc)3(Man)9(GlcNAc)2]is the same in plants, animals, and single cell eukaryotes. This precursor is linked to a dolichol, a long-chain polyisoprenoid lipid that act as a carrier for the oligosaccharide.The oligosaccharide then is transfer by an ER enzyme from the dodichol carrier to an asparagine residue on a nascent protein. The oligosaccharide chain is then processed as the glycoprotein moves through the Golgi apparatus.In some cases this modification involves attachment of more mannose groups; in other cases a more complex type of structure is attached.

o 4 selected references:

o 7 GO-Terms:

o 156 Instances for MOD_N-GLC_1
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
TNFL6_HUMAN 183 188 YKKGGLVINETGLYFVYSKV true positive --- Homo sapiens (Human)
TNFL6_HUMAN 249 254 SSYLGAVFNLTSADHLYVNV true positive --- Homo sapiens (Human)
TNFL6_HUMAN 259 264 TSADHLYVNVSELSLVNFEE true positive --- Homo sapiens (Human)
ACES_HUMAN 380 385 GAPGFSKDNESLISRAEFLA true positive --- Homo sapiens (Human)
ACES_HUMAN 494 499 GIPLDPSRNYTAEEKIFAQR true positive --- Homo sapiens (Human)
BMP1_HUMAN 90 95 SIKAAVPGNTSTPSCQSTNG true positive --- Homo sapiens (Human)
BMP1_HUMAN 141 146 VIPFVIGGNFTGSQRAVFRQ true positive --- Homo sapiens (Human)
BMP1_HUMAN 331 336 ETLQDSTGNFSSPEYPNGYS true positive --- Homo sapiens (Human)
BMP1_HUMAN 362 367 TPGEKIILNFTSLDLYRSRL true positive --- Homo sapiens (Human)
CASR_HUMAN 89 94 NSSPALLPNLTLGYRIFDTC true positive --- Homo sapiens (Human)
CASR_HUMAN 129 134 SLNLDEFCNCSEHIPSTIAV true positive --- Homo sapiens (Human)
CASR_HUMAN 260 265 QHVVEVIQNSTAKVIVVFSS true positive --- Homo sapiens (Human)
CASR_HUMAN 286 291 LIKEIVRRNITGKIWLASEA true positive --- Homo sapiens (Human)
CASR_HUMAN 385 390 EESGDRFSNSSTAFRPLCTG true positive --- Homo sapiens (Human)
CASR_HUMAN 445 450 LPGRGLFTNGSCADIKKVEA true positive --- Homo sapiens (Human)
CASR_HUMAN 467 472 VLKHLRHLNFTNNMGEQVTF true positive --- Homo sapiens (Human)
CASR_HUMAN 487 492 DECGDLVGNYSIINWHLSPE true positive --- Homo sapiens (Human)
CASR_HUMAN 540 545 FSREVPFSNCSRDCLAGTRK true positive --- Homo sapiens (Human)
IL3RB_HUMAN 57 62 TQDAQRLVNVTLIRRVNEDL true positive --- Homo sapiens (Human)
IL3RB_HUMAN 190 195 EDAAILLSNTSQATLGPEHL true positive --- Homo sapiens (Human)
IL3RB_HUMAN 345 350 IQMAPPSLNVTKDGDSYSLR true positive --- Homo sapiens (Human)
IL6RA_HUMAN 54 59 CPGVEPEDNATVHWVLRKPA true positive --- Homo sapiens (Human)
IL6RA_HUMAN 92 97 SVQLHDSGNYSCYRAGRPAG true positive --- Homo sapiens (Human)
IL6RA_HUMAN 220 225 ILQPDPPANITVTAVARNPR true positive --- Homo sapiens (Human)
PRLR_HUMAN 58 63 GTDGGLPTNYSLTYHREGET true positive --- Homo sapiens (Human)
PRLR_HUMAN 103 108 WRTYIMMVNATNQMGSSFSD true positive --- Homo sapiens (Human)
PRLR_HUMAN 232 237 QIPSDFTMNDTTVWISVAVL true positive --- Homo sapiens (Human)
TPO_HUMAN 196 201 VLTLNELPNRTSGLLETNFT true positive --- Homo sapiens (Human)
TPO_HUMAN 205 210 RTSGLLETNFTASARTTGSG true positive --- Homo sapiens (Human)
TPO_HUMAN 233 238 RAKIPGLLNQTSRSLDQIPG true positive --- Homo sapiens (Human)
TPO_HUMAN 254 259 LNRIHELLNGTRGLFPGPSR true positive --- Homo sapiens (Human)
TPO_HUMAN 339 344 PTPTSPLLNTSYTHSQNLSQ true positive --- Homo sapiens (Human)
TPO_HUMAN 347 352 PTSPLLNTSYTHSQNLSQEG true positive --- Homo sapiens (Human)
BMP1_HUMAN 598 603 CGGFLTKLNGSITSPGWPKE true positive --- Homo sapiens (Human)
ACES_HUMAN 295 300 CPPGGTGGNDTELVACLRTR true positive --- Homo sapiens (Human)
HEXB_HUMAN 326 331 FGPINPTLNTTYSFLTTFFK true positive --- Homo sapiens (Human)
TLR4_HUMAN 525 530 SLSSLQVLNMSHNNFFSLDT true positive --- Homo sapiens (Human)
TLR4_HUMAN 574 579 FPSSLAFLNLTQNDFACTCE true positive --- Homo sapiens (Human)
PRIO_HUMAN 180 185 NNFVHDCVNITIKQHTVTTT true positive --- Homo sapiens (Human)
PRIO_HUMAN 196 201 VTTTTKGENFTETDVKMMER true positive --- Homo sapiens (Human)
B3AT_HUMAN 641 646 VPDGFKVSNSSARGWVIHPL true positive --- Homo sapiens (Human)
FSHB_HUMAN 24 29 CCNSCELTNITIAIEKEECR true positive --- Homo sapiens (Human)
INHA_HUMAN 301 306 GCGLHIPPNLSLPVPGAPPT true positive --- Homo sapiens (Human)
PMP22_HUMAN 40 45 GHATDLWQNCSTSSSGNVHH true positive --- Homo sapiens (Human)
HEXB_HUMAN 83 88 NFYISHSPNSTAGPSCTLLE true positive --- Homo sapiens (Human)
HEXB_HUMAN 189 194 DSYGTFTINESTIIDSPRFS true positive --- Homo sapiens (Human)
ABCA4_HUMAN 97 102 SPGIVSNYNNSILARVYRDF true positive --- Homo sapiens (Human)
ABCA4_HUMAN 414 419 ARRILKNANSTFEELEHVRK true positive --- Homo sapiens (Human)
ABCA4_HUMAN 443 448 PQIWYFFDNSTQMNMIRDTL true positive --- Homo sapiens (Human)
ABCA4_HUMAN 503 508 NFDWRDIFNITDRTLRLVNQ true positive --- Homo sapiens (Human)
ABCA4_HUMAN 1468 1473 WKTPSVSPNITQLFQKQKWT true positive --- Homo sapiens (Human)
ABCA4_HUMAN 1528 1533 ILQDLTDRNISDFLVKTYPA true positive --- Homo sapiens (Human)
ABCA4_HUMAN 1587 1592 LSDLGRIMNVSGGPITREAS true positive --- Homo sapiens (Human)
ABCA4_HUMAN 1661 1666 ITVISQPLNLTKEQLSEITV true positive --- Homo sapiens (Human)
FA9_HUMAN 202 207 VFPDVDYVNSTEAETILDNI true positive --- Homo sapiens (Human)
FA9_HUMAN 212 217 TEAETILDNITQSTQSFNDF true positive --- Homo sapiens (Human)
CO6_HUMAN 323 328 IHKVMKVLNFTTKAKDLHLS true positive --- Homo sapiens (Human)
THYG_HUMAN 75 80 RSCWCVGANGSEVLGSRQPG true positive --- Homo sapiens (Human)
THYG_HUMAN 109 114 QILLSGYINSTDTSYLPQCQ true positive --- Homo sapiens (Human)
THYG_HUMAN 197 202 MPVQCKFVNTTDMMIFDLVH true positive --- Homo sapiens (Human)
THYG_HUMAN 483 488 FLVNVGQFNLSGALGTRGTF true positive --- Homo sapiens (Human)
THYG_HUMAN 528 533 PLSVGLDSNSSTGTPEAAKK true positive --- Homo sapiens (Human)
THYG_HUMAN 747 752 RTVQALLSNSSMLPTLSDTY true positive --- Homo sapiens (Human)
THYG_HUMAN 815 820 SYREAASGNFSLFIQSLYEA true positive --- Homo sapiens (Human)
THYG_HUMAN 946 951 TEEIVSASNSSRFPLGESFL true positive --- Homo sapiens (Human)
THYG_HUMAN 1219 1224 SPRCPLPFNASEVVGGTILC true positive --- Homo sapiens (Human)
THYG_HUMAN 1347 1352 TLVSIPVCNNSSVQVGCLTR true positive --- Homo sapiens (Human)
THYG_HUMAN 1364 1369 LTRERLGVNVTWKSRLEDIP true positive --- Homo sapiens (Human)
THYG_HUMAN 1715 1720 IVFSASGANLTDAHLFCLLA true positive --- Homo sapiens (Human)
THYG_HUMAN 1773 1778 MDPSEAWANATCPGVTYDQE true positive --- Homo sapiens (Human)
THYG_HUMAN 2012 2017 CCTGFGFLNVSQLKGGEVTC true positive --- Homo sapiens (Human)
THYG_HUMAN 2249 2254 RFQAPEPLNWTGSWDASKPR true positive --- Homo sapiens (Human)
THYG_HUMAN 2294 2299 FIPQNVAPNASVLVFFHNTM true positive --- Homo sapiens (Human)
THYG_HUMAN 2581 2586 ASFSRALENATRDYFIICPI true positive --- Homo sapiens (Human)
IL6RB_HUMAN 42 47 SPVVQLHSNFTAVCVLKEKC true positive --- Homo sapiens (Human)
IL6RB_HUMAN 82 87 PKEQYTIINRTASSVTFTDI true positive --- Homo sapiens (Human)
IL6RB_HUMAN 130 135 GLPPEKPKNLSCIVNEGKKM true positive --- Homo sapiens (Human)
IL6RB_HUMAN 156 161 GRETHLETNFTLKSEWATHK true positive --- Homo sapiens (Human)
IL6RB_HUMAN 226 231 KVKPNPPHNLSVINSEELSS true positive --- Homo sapiens (Human)
IL6RB_HUMAN 378 383 TRWKSHLQNYTVNATKLTVN true positive --- Homo sapiens (Human)
IL6RB_HUMAN 382 387 SHLQNYTVNATKLTVNLTND true positive --- Homo sapiens (Human)
IL6RB_HUMAN 552 557 DVQNGFIRNYTIFYRTIIGN true positive --- Homo sapiens (Human)
IL6RB_HUMAN 563 568 IFYRTIIGNETAVNVDSSHT true positive --- Homo sapiens (Human)
OXYR_HUMAN 7 12 MEGALAANWSAEAANASAAP true positive --- Homo sapiens (Human)
OXYR_HUMAN 14 19 ANWSAEAANASAAPPGAEGN true positive --- Homo sapiens (Human)
OXYR_HUMAN 25 30 AAPPGAEGNRTAGPPRRNEA true positive --- Homo sapiens (Human)
NK2R_HUMAN 10 15 TCDIVTEANISSGPESNTTG true positive --- Homo sapiens (Human)
NK2R_HUMAN 18 23 NISSGPESNTTGITAFSMPS true positive --- Homo sapiens (Human)
MOGS_HUMAN 656 661 LGVFADFGNHTKAVQLKPRP true positive --- Homo sapiens (Human)
ENV_HV1B1 391 396 YCNSTQLFNSTWFNSTWSTK true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1H2 300 305 EINCTRPNNNTRKRIRIQRG true positive --- HIV-1 M:B_HXB2R
ENV_HV1H2 338 343 CNISRAKWNNTLKQIASKLR true positive --- HIV-1 M:B_HXB2R
ENV_HV1H2 391 396 YCNSTQLFNSTWFNSTWSTE true positive --- HIV-1 M:B_HXB2R
FUS_NIPAV 66 71 IKMIPNVSNMSQCTGSVMEN true positive --- Nipah virus
ENV_HV1B1 87 92 NPQEVVLVNVTENFNMWKND true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 185 190 KLDIIPIDNDTTSYTLTSCN true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 140 145 DLKNDTNTNSSSGRMIMEKG true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 159 164 GEIKNCSFNISTSIRGKVQK true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 355 360 KLREQFGNNKTIIFKQSSGG true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 233 238 LKCNNKTFNGTGPCTNVSTV true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 405 410 STWSTKGSNNTEGSDTITLP true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 396 401 QLFNSTWFNSTWSTKGSNNT true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 447 452 SGQIRCSSNITGLLLTRDGG true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 624 629 KSLEQIWNNMTWMEWDREIN true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 615 620 VPWNASWSNKSLEQIWNNMT true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 636 641 MEWDREINNYTSLIHSLIEE true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 673 678 WASLWNWFNITNWLWYIKLF true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1H2 261 266 VVSTQLLLNGSLAEEEVVIR true positive --- HIV-1 M:B_HXB2R
ENV_HV1H2 447 452 SGQIRCSSNITGLLLTRDGG true positive --- HIV-1 M:B_HXB2R
FUS_NIPAV 98 103 KGALEIYKNNTHDLVGDVRL true positive --- Nipah virus
FUS_NIPAV 413 418 EQTLLMIDNTTCPTAVLGNV true positive --- Nipah virus
FUS_NIPAV 463 468 ISSQISSMNQSLQQSKDYIK true positive --- Nipah virus
POLG_HCVH 195 200 PASAYQVRNSSGLYHVTNDC true positive --- Hepatitis C virus (isolate H)
POLG_HCVH 233 238 CVPCVREGNASRCWVAVTPT true positive --- Hepatitis C virus (isolate H)
POLG_HCVH 304 309 HHWTTQDCNCSIYPGHITGH true positive --- Hepatitis C virus (isolate H)
SIAL_HUMAN 176 181 VDENEQGINGTSTNSTEAEN true positive --- Homo sapiens (Human)
SIAL_HUMAN 181 186 QGINGTSTNSTEAENGNGSS true positive --- Homo sapiens (Human)
SIAL_HUMAN 189 194 NSTEAENGNGSSGGDNGEEG true positive --- Homo sapiens (Human)
ENV_HV1B1 196 201 TSYTLTSCNTSVITQACPKV true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 240 245 FNGTGPCTNVSTVQCTHGIR true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 261 266 VVSTQLLLNGSLAEEEVVIR true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 294 299 QLNQSVEINCTRPNNNTRKS true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 300 305 EINCTRPNNNTRKSIRIQRG true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 338 343 CNISRAKWNNTLKQIDSKLR true positive --- Human immunodeficiency virus type 1 BH10
Q3I0Y8_WNV 443 448 PTTVESHGNYSTQVGATQAG true positive 2HG0
 West Nile virus
ENV_HV1H2 396 401 QLFNSTWFNSTWSTEGSNNT true positive --- HIV-1 M:B_HXB2R
SPIKE_CVHSA 226 231 IFKLPLGINITNFRAILTAF true positive --- SARS coronavirus
SPIKE_CVHSA 118 123 SQSVIIINNSTNVVIRACNF true positive --- SARS coronavirus
SPIKE_CVHSA 268 273 TFMLKYDENGTITDAVDCSQ true positive --- SARS coronavirus
SPIKE_CVHSA 317 322 SGDVVRFPNITNLCPFGEVF true positive --- SARS coronavirus
SPIKE_CVHSA 329 334 LCPFGEVFNATKFPSVYAWE true positive --- SARS coronavirus
SPIKE_CVHSA 356 361 VADYSVLYNSTFFSTFKCYG true positive --- SARS coronavirus
SPIKE_CVHSA 782 787 TLKYFGGFNFSQILPDPLKP true positive --- SARS coronavirus
SPIKE_CVHSA 1079 1084 PREGVFVFNGTSWFITQRNF true positive --- SARS coronavirus
SPIKE_CVHSA 1139 1144 EELDKYFKNHTSPDVDLGDI true positive --- SARS coronavirus
SPIKE_CVHSA 1154 1159 DLGDISGINASVVNIQKEID true positive --- SARS coronavirus
SPIKE_CVHSA 1175 1180 LNEVAKNLNESLIDLQELGK true positive --- SARS coronavirus
VGP_EBOZM 39 44 SIPLGVIHNSTLQVSDVDKL true positive --- Ebola virus - Mayinga, Zaire, 1976
VGP_EBOZM 295 300 WAFWETKKNLTRKIRSEELS true positive --- Ebola virus - Mayinga, Zaire, 1976
VME1_CVHSA 3 8 MADNGTITVEELKQLLEQWN true positive --- SARS coronavirus
WFS1_HUMAN 27 32 QPQARSRLNATASLEQERSE true positive --- Homo sapiens (Human)
WFS1_HUMAN 334 339 LIFFFIVSNLTIDFFAFFIP true positive --- Homo sapiens (Human)
WFS1_HUMAN 499 504 PVGHLVVLNVSVPCLLYVYL true positive --- Homo sapiens (Human)
WFS1_HUMAN 660 665 RSEGMKVYNSTLTWQQYGAL true positive --- Homo sapiens (Human)
WFS1_HUMAN 745 750 AYPACSPGNTSTAEEELCRL true positive --- Homo sapiens (Human)
ENV_HV1B1 288 293 AKTIIVQLNQSVEINCTRPN true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 331 336 GNMRQAHCNISRAKWNNTLK true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 385 390 CGGEFFYCNSTQLFNSTWFN true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1B1 462 467 TRDGGNSNNESEIFRPGGGD true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1H2 294 299 QLNTSVEINCTRPNNNTRKR true positive --- HIV-1 M:B_HXB2R
ENV_HV1H2 385 390 CGGEFFYCNSTQLFNSTWFN true positive --- HIV-1 M:B_HXB2R
FUS_NIPAV 63 68 DIVIKMIPNVSNMSQCTGSV true positive --- Nipah virus
ENV_HV1B1 275 280 EEVVIRSANFTDNAKTIIVQ true positive --- Human immunodeficiency virus type 1 BH10
ENV_HV1H2 331 336 GNMRQAHCNISRAKWNNTLK true positive --- HIV-1 M:B_HXB2R
POLG_HCVH 208 213 YHVTNDCPNSSVVYEAADAI true positive --- Hepatitis C virus (isolate H)
SPIKE_CVHSA 1055 1060 TYVPSQERNFTTAPAICHEG true positive --- SARS coronavirus

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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