The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Accession:
Functional site class:
Glycosaminoglycan attachment site
Functional site description:
Proteoglycans are extracellular proteins with glycosaminoglycan chains attached at a serine residue.
ELM Description:
The glycosaminoglycan attachment site is an exposed serine which accepts transfer of xylose from UDP-xylose to the hydroxyl group by protein xylosyl transferase (EC 2.4.2.26).
Pattern: [ED]{0,3}.(S)[GA].
Pattern Probability: 0.0179191
Present in taxon: Metazoa
Interaction Domains:
o See 6 Instances for MOD_GlcNHglycan
o Abstract
Proteoglycans are found at the cell surface and in the extracellular matrix. They are important for cell communication, playing a role for example in morphogenesis and development. Mutations in some proteoglycans are associated with an inherited predisposition to cancer. The core protein is modified by attachment of the glycosaminoglycan chain at an exposed serine residue. For heparan sulphate, the process begins by transfer of xylose from UDP-xylose to the serine hydroxyl group by protein xylosyl transferase (EC 2.4.2.26) in the Golgi stack. The system appears to have evolved in metazoan animals.
o 6 GO-Terms:

o 6 Instances for MOD_GlcNHglycan
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P50605 sdn-1
SDC_CAEEL
85 88 DEDGDDVHGSGKPPSSATTK TP 2 Caenorhabditis elegans
P50605 sdn-1
SDC_CAEEL
70 73 RLADIEVNGSGYPTDDEDGD TP 2 Caenorhabditis elegans
P18828 Sdc1
SDC1_MOUSE
46 49 GDDSDNFSGSGTGALPDTLS TP 2 Mus musculus (House mouse)
P18828 Sdc1
SDC1_MOUSE
36 39 NVPPEDQDGSGDDSDNFSGS TP 2 Mus musculus (House mouse)
P18828 Sdc1
SDC1_MOUSE
216 219 GEQDFTFETSGENTAVAAVE TP 2 Mus musculus (House mouse)
P18828 Sdc1
SDC1_MOUSE
206 209 ANQLPAGEGSGEQDFTFETS TP 2 Mus musculus (House mouse)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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