The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Accession:
Functional site class:
N-glycosylation site
Functional site description:
N-linked glycosylation is a co-translational process involving the transfer of a oligosaccharide chain to asparagine residue in the protein.
ELMs with same func. site: MOD_N-GLC_1  MOD_N-GLC_2 
ELM Description:
Generic motif for N-glycosylation. It was shown that Trp, Asp, and Glu are uncommon before the Ser/Thr position (Shakin-Eshleman,1996). Efficient glycosylation usually occurs when ~60 residues or more separate the glycosylation acceptor site from the C-terminus.
Pattern: .(N)[^P][ST]..
Pattern Probability: 0.0050178
Present in taxon: Eukaryota
Interaction Domain:
STT3 (PF02516) Oligosaccharyl transferase STT3 subunit (Stochiometry: 1 : 1)
PDB Structure: 2HG0
o See 156 Instances for MOD_N-GLC_1
o Abstract
N-glycosylation is the most common modification of secretory and membrane-bound proteins in eukaryotic cells. The whole process of N-glycosylation comprises more than 100 enzymes and transport proteins. The biosynthesis of all N-linked oligosaccharides begins in the ER with a large precursor oligosaccharid. The structure of this oligosaccharide [(Glc)3(Man)9(GlcNAc)2] is the same in plants, animals, and single cell eukaryotes. This precursor is linked to a dolichol, a long-chain polyisoprenoid lipid that act as a carrier for the oligosaccharide. The oligosaccharide is then transferred by an ER enzyme from the dodichol carrier to an asparagine residue on a nascent protein. The oligosaccharide chain is then processed as the glycoprotein moves through the Golgi apparatus. In some cases this modification involves attachment of more mannose groups, in other cases a more complex type of structure is attached.
o 4 selected references:

o 7 GO-Terms:

o 156 Instances for MOD_N-GLC_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P59596 M
VME1_CVHSA
3 8 MADNGTITVEELKQLLEQWN TP 1 SARS coronavirus
Q05320 GP
VGP_EBOZM
295 300 WAFWETKKNLTRKIRSEELS TP 1 Ebola virus - Mayinga, Zaire, 1976
Q05320 GP
VGP_EBOZM
39 44 SIPLGVIHNSTLQVSDVDKL TP 1 Ebola virus - Mayinga, Zaire, 1976
P59594 S
SPIKE_CVHSA
1175 1180 LNEVAKNLNESLIDLQELGK TP 2 SARS coronavirus
P59594 S
SPIKE_CVHSA
1154 1159 DLGDISGINASVVNIQKEID TP 2 SARS coronavirus
P59594 S
SPIKE_CVHSA
1139 1144 EELDKYFKNHTSPDVDLGDI TP 2 SARS coronavirus
P59594 S
SPIKE_CVHSA
1079 1084 PREGVFVFNGTSWFITQRNF TP 2 SARS coronavirus
P59594 S
SPIKE_CVHSA
1055 1060 TYVPSQERNFTTAPAICHEG TP 2 SARS coronavirus
P59594 S
SPIKE_CVHSA
782 787 TLKYFGGFNFSQILPDPLKP TP 2 SARS coronavirus
P59594 S
SPIKE_CVHSA
356 361 VADYSVLYNSTFFSTFKCYG TP 2 SARS coronavirus
P59594 S
SPIKE_CVHSA
329 334 LCPFGEVFNATKFPSVYAWE TP 2 SARS coronavirus
P59594 S
SPIKE_CVHSA
317 322 SGDVVRFPNITNLCPFGEVF TP 2 SARS coronavirus
P59594 S
SPIKE_CVHSA
268 273 TFMLKYDENGTITDAVDCSQ TP 2 SARS coronavirus
P59594 S
SPIKE_CVHSA
226 231 IFKLPLGINITNFRAILTAF TP 2 SARS coronavirus
P59594 S
SPIKE_CVHSA
118 123 SQSVIIINNSTNVVIRACNF TP 2 SARS coronavirus
Q3I0Y8 
Q3I0Y8_WNV
443 448 PTTVESHGNYSTQVGATQAG TP 1 West Nile virus
P27958 
POLG_HCVH
304 309 HHWTTQDCNCSIYPGHITGH TP 1 Hepatitis C virus (isolate H)
P27958 
POLG_HCVH
233 238 CVPCVREGNASRCWVAVTPT TP 1 Hepatitis C virus (isolate H)
P27958 
POLG_HCVH
208 213 YHVTNDCPNSSVVYEAADAI TP 1 Hepatitis C virus (isolate H)
P27958 
POLG_HCVH
195 200 PASAYQVRNSSGLYHVTNDC TP 1 Hepatitis C virus (isolate H)
Q9IH63 F
FUS_NIPAV
463 468 ISSQISSMNQSLQQSKDYIK TP 1 Nipah virus
Q9IH63 F
FUS_NIPAV
413 418 EQTLLMIDNTTCPTAVLGNV TP 1 Nipah virus
Q9IH63 F
FUS_NIPAV
98 103 KGALEIYKNNTHDLVGDVRL TP 1 Nipah virus
Q9IH63 F
FUS_NIPAV
63 68 DIVIKMIPNVSNMSQCTGSV TP 1 Nipah virus
P04578 env
ENV_HV1H2
447 452 SGQIRCSSNITGLLLTRDGG TP 1 HIV-1 M:B_HXB2R
P04578 env
ENV_HV1H2
396 401 QLFNSTWFNSTWSTEGSNNT TP 1 HIV-1 M:B_HXB2R
P04578 env
ENV_HV1H2
385 390 CGGEFFYCNSTQLFNSTWFN TP 1 HIV-1 M:B_HXB2R
P04578 env
ENV_HV1H2
331 336 GNMRQAHCNISRAKWNNTLK TP 1 HIV-1 M:B_HXB2R
P04578 env
ENV_HV1H2
294 299 QLNTSVEINCTRPNNNTRKR TP 1 HIV-1 M:B_HXB2R
P04578 env
ENV_HV1H2
261 266 VVSTQLLLNGSLAEEEVVIR TP 1 HIV-1 M:B_HXB2R
P03375 env
ENV_HV1B1
673 678 WASLWNWFNITNWLWYIKLF TP 1 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
636 641 MEWDREINNYTSLIHSLIEE TP 1 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
624 629 KSLEQIWNNMTWMEWDREIN TP 1 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
615 620 VPWNASWSNKSLEQIWNNMT TP 1 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
462 467 TRDGGNSNNESEIFRPGGGD TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
447 452 SGQIRCSSNITGLLLTRDGG TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
405 410 STWSTKGSNNTEGSDTITLP TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
396 401 QLFNSTWFNSTWSTKGSNNT TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
385 390 CGGEFFYCNSTQLFNSTWFN TP 1 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
355 360 KLREQFGNNKTIIFKQSSGG TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
338 343 CNISRAKWNNTLKQIDSKLR TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
331 336 GNMRQAHCNISRAKWNNTLK TP 1 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
300 305 EINCTRPNNNTRKSIRIQRG TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
294 299 QLNQSVEINCTRPNNNTRKS TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
288 293 AKTIIVQLNQSVEINCTRPN TP 1 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
275 280 EEVVIRSANFTDNAKTIIVQ TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
261 266 VVSTQLLLNGSLAEEEVVIR TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
240 245 FNGTGPCTNVSTVQCTHGIR TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
233 238 LKCNNKTFNGTGPCTNVSTV TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
196 201 TSYTLTSCNTSVITQACPKV TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
185 190 KLDIIPIDNDTTSYTLTSCN TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
159 164 GEIKNCSFNISTSIRGKVQK TP 2 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
140 145 DLKNDTNTNSSSGRMIMEKG TP 3 Human immunodeficiency virus type 1 BH10
P03375 env
ENV_HV1B1
87 92 NPQEVVLVNVTENFNMWKND TP 1 Human immunodeficiency virus type 1 BH10
O76024 WFS1
WFS1_HUMAN
27 32 QPQARSRLNATASLEQERSE TP 1 Homo sapiens (Human)
O76024 WFS1
WFS1_HUMAN
745 750 AYPACSPGNTSTAEEELCRL TP 1 Homo sapiens (Human)
O76024 WFS1
WFS1_HUMAN
660 665 RSEGMKVYNSTLTWQQYGAL TP 1 Homo sapiens (Human)
P21815 IBSP
SIAL_HUMAN
189 194 NSTEAENGNGSSGGDNGEEG TP 1 Homo sapiens (Human)
P21815 IBSP
SIAL_HUMAN
181 186 QGINGTSTNSTEAENGNGSS TP 1 Homo sapiens (Human)
P21815 IBSP
SIAL_HUMAN
176 181 VDENEQGINGTSTNSTEAEN TP 1 Homo sapiens (Human)
O76024 WFS1
WFS1_HUMAN
499 504 PVGHLVVLNVSVPCLLYVYL TP 1 Homo sapiens (Human)
O76024 WFS1
WFS1_HUMAN
334 339 LIFFFIVSNLTIDFFAFFIP TP 1 Homo sapiens (Human)
Q9IH63 F
FUS_NIPAV
66 71 IKMIPNVSNMSQCTGSVMEN TP 1 Nipah virus
P04578 env
ENV_HV1H2
391 396 YCNSTQLFNSTWFNSTWSTE TP 1 HIV-1 M:B_HXB2R
P04578 env
ENV_HV1H2
338 343 CNISRAKWNNTLKQIASKLR TP 1 HIV-1 M:B_HXB2R
P04578 env
ENV_HV1H2
300 305 EINCTRPNNNTRKRIRIQRG TP 1 HIV-1 M:B_HXB2R
P03375 env
ENV_HV1B1
391 396 YCNSTQLFNSTWFNSTWSTK TP 2 Human immunodeficiency virus type 1 BH10
Q13724 MOGS
MOGS_HUMAN
656 661 LGVFADFGNHTKAVQLKPRP TP 1 Homo sapiens (Human)
Q01453 PMP22
PMP22_HUMAN
40 45 GHATDLWQNCSTSSSGNVHH TP 1 Homo sapiens (Human)
P13671 C6
CO6_HUMAN
323 328 IHKVMKVLNFTTKAKDLHLS TP 1 Homo sapiens (Human)
P05111 INHA
INHA_HUMAN
301 306 GCGLHIPPNLSLPVPGAPPT TP 1 Homo sapiens (Human)
P01225 FSHB
FSHB_HUMAN
24 29 CCNSCELTNITIAIEKEECR TP 1 Homo sapiens (Human)
P02730 SLC4A1
B3AT_HUMAN
641 646 VPDGFKVSNSSARGWVIHPL TP 1 Homo sapiens (Human)
O00206 TLR4
TLR4_HUMAN
574 579 FPSSLAFLNLTQNDFACTCE TP 1 Homo sapiens (Human)
O00206 TLR4
TLR4_HUMAN
525 530 SLSSLQVLNMSHNNFFSLDT TP 1 Homo sapiens (Human)
P00740 F9
FA9_HUMAN
212 217 TEAETILDNITQSTQSFNDF TP 1 Homo sapiens (Human)
P00740 F9
FA9_HUMAN
202 207 VFPDVDYVNSTEAETILDNI TP 1 Homo sapiens (Human)
P04156 PRNP
PRIO_HUMAN
196 201 VTTTTKGENFTETDVKMMER TP 1 Homo sapiens (Human)
P04156 PRNP
PRIO_HUMAN
180 185 NNFVHDCVNITIKQHTVTTT TP 1 Homo sapiens (Human)
P40225 THPO
TPO_HUMAN
196 201 VLTLNELPNRTSGLLETNFT TP 1 Homo sapiens (Human)
P40225 THPO
TPO_HUMAN
205 210 RTSGLLETNFTASARTTGSG TP 1 Homo sapiens (Human)
P40225 THPO
TPO_HUMAN
233 238 RAKIPGLLNQTSRSLDQIPG TP 1 Homo sapiens (Human)
P40225 THPO
TPO_HUMAN
254 259 LNRIHELLNGTRGLFPGPSR TP 1 Homo sapiens (Human)
P40225 THPO
TPO_HUMAN
339 344 PTPTSPLLNTSYTHSQNLSQ TP 1 Homo sapiens (Human)
P40225 THPO
TPO_HUMAN
347 352 PTSPLLNTSYTHSQNLSQEG TP 1 Homo sapiens (Human)
P21452 TACR2
NK2R_HUMAN
10 15 TCDIVTEANISSGPESNTTG TP 1 Homo sapiens (Human)
P21452 TACR2
NK2R_HUMAN
18 23 NISSGPESNTTGITAFSMPS TP 1 Homo sapiens (Human)
P16471 PRLR
PRLR_HUMAN
232 237 QIPSDFTMNDTTVWISVAVL TP 1 Homo sapiens (Human)
P16471 PRLR
PRLR_HUMAN
103 108 WRTYIMMVNATNQMGSSFSD TP 1 Homo sapiens (Human)
P16471 PRLR
PRLR_HUMAN
58 63 GTDGGLPTNYSLTYHREGET TP 1 Homo sapiens (Human)
P30559 OXTR
OXYR_HUMAN
25 30 AAPPGAEGNRTAGPPRRNEA TP 1 Homo sapiens (Human)
P30559 OXTR
OXYR_HUMAN
14 19 ANWSAEAANASAAPPGAEGN TP 1 Homo sapiens (Human)
P30559 OXTR
OXYR_HUMAN
7 12 MEGALAANWSAEAANASAAP TP 1 Homo sapiens (Human)
P08887 IL6R
IL6RA_HUMAN
220 225 ILQPDPPANITVTAVARNPR TP 1 Homo sapiens (Human)
P08887 IL6R
IL6RA_HUMAN
92 97 SVQLHDSGNYSCYRAGRPAG TP 1 Homo sapiens (Human)
P08887 IL6R
IL6RA_HUMAN
54 59 CPGVEPEDNATVHWVLRKPA TP 1 Homo sapiens (Human)
P32927 CSF2RB
IL3RB_HUMAN
190 195 EDAAILLSNTSQATLGPEHL TP 1 Homo sapiens (Human)
P32927 CSF2RB
IL3RB_HUMAN
57 62 TQDAQRLVNVTLIRRVNEDL TP 1 Homo sapiens (Human)
P32927 CSF2RB
IL3RB_HUMAN
345 350 IQMAPPSLNVTKDGDSYSLR TP 1 Homo sapiens (Human)
P41180 CASR
CASR_HUMAN
540 545 FSREVPFSNCSRDCLAGTRK TP 1 Homo sapiens (Human)
P41180 CASR
CASR_HUMAN
89 94 NSSPALLPNLTLGYRIFDTC TP 1 Homo sapiens (Human)
P41180 CASR
CASR_HUMAN
129 134 SLNLDEFCNCSEHIPSTIAV TP 1 Homo sapiens (Human)
P41180 CASR
CASR_HUMAN
260 265 QHVVEVIQNSTAKVIVVFSS TP 1 Homo sapiens (Human)
P41180 CASR
CASR_HUMAN
286 291 LIKEIVRRNITGKIWLASEA TP 1 Homo sapiens (Human)
P41180 CASR
CASR_HUMAN
385 390 EESGDRFSNSSTAFRPLCTG TP 1 Homo sapiens (Human)
P41180 CASR
CASR_HUMAN
445 450 LPGRGLFTNGSCADIKKVEA TP 1 Homo sapiens (Human)
P41180 CASR
CASR_HUMAN
467 472 VLKHLRHLNFTNNMGEQVTF TP 1 Homo sapiens (Human)
P41180 CASR
CASR_HUMAN
487 492 DECGDLVGNYSIINWHLSPE TP 1 Homo sapiens (Human)
P40189 IL6ST
IL6RB_HUMAN
563 568 IFYRTIIGNETAVNVDSSHT TP 1 Homo sapiens (Human)
P40189 IL6ST
IL6RB_HUMAN
552 557 DVQNGFIRNYTIFYRTIIGN TP 1 Homo sapiens (Human)
P40189 IL6ST
IL6RB_HUMAN
382 387 SHLQNYTVNATKLTVNLTND TP 1 Homo sapiens (Human)
P40189 IL6ST
IL6RB_HUMAN
378 383 TRWKSHLQNYTVNATKLTVN TP 1 Homo sapiens (Human)
P40189 IL6ST
IL6RB_HUMAN
226 231 KVKPNPPHNLSVINSEELSS TP 1 Homo sapiens (Human)
P40189 IL6ST
IL6RB_HUMAN
156 161 GRETHLETNFTLKSEWATHK TP 1 Homo sapiens (Human)
P40189 IL6ST
IL6RB_HUMAN
130 135 GLPPEKPKNLSCIVNEGKKM TP 1 Homo sapiens (Human)
P40189 IL6ST
IL6RB_HUMAN
82 87 PKEQYTIINRTASSVTFTDI TP 1 Homo sapiens (Human)
P40189 IL6ST
IL6RB_HUMAN
42 47 SPVVQLHSNFTAVCVLKEKC TP 1 Homo sapiens (Human)
P78363 ABCA4
ABCA4_HUMAN
1587 1592 LSDLGRIMNVSGGPITREAS TP 1 Homo sapiens (Human)
P78363 ABCA4
ABCA4_HUMAN
97 102 SPGIVSNYNNSILARVYRDF TP 1 Homo sapiens (Human)
P78363 ABCA4
ABCA4_HUMAN
414 419 ARRILKNANSTFEELEHVRK TP 1 Homo sapiens (Human)
P78363 ABCA4
ABCA4_HUMAN
443 448 PQIWYFFDNSTQMNMIRDTL TP 1 Homo sapiens (Human)
P78363 ABCA4
ABCA4_HUMAN
503 508 NFDWRDIFNITDRTLRLVNQ TP 1 Homo sapiens (Human)
P78363 ABCA4
ABCA4_HUMAN
1468 1473 WKTPSVSPNITQLFQKQKWT TP 1 Homo sapiens (Human)
P78363 ABCA4
ABCA4_HUMAN
1528 1533 ILQDLTDRNISDFLVKTYPA TP 1 Homo sapiens (Human)
P78363 ABCA4
ABCA4_HUMAN
1661 1666 ITVISQPLNLTKEQLSEITV TP 1 Homo sapiens (Human)
P13497 BMP1
BMP1_HUMAN
362 367 TPGEKIILNFTSLDLYRSRL TP 1 Homo sapiens (Human)
P13497 BMP1
BMP1_HUMAN
598 603 CGGFLTKLNGSITSPGWPKE TP 1 Homo sapiens (Human)
P13497 BMP1
BMP1_HUMAN
331 336 ETLQDSTGNFSSPEYPNGYS TP 1 Homo sapiens (Human)
P13497 BMP1
BMP1_HUMAN
141 146 VIPFVIGGNFTGSQRAVFRQ TP 1 Homo sapiens (Human)
P13497 BMP1
BMP1_HUMAN
90 95 SIKAAVPGNTSTPSCQSTNG TP 1 Homo sapiens (Human)
P22303 ACHE
ACES_HUMAN
295 300 CPPGGTGGNDTELVACLRTR TP 1 Homo sapiens (Human)
P22303 ACHE
ACES_HUMAN
380 385 GAPGFSKDNESLISRAEFLA TP 1 Homo sapiens (Human)
P22303 ACHE
ACES_HUMAN
494 499 GIPLDPSRNYTAEEKIFAQR TP 1 Homo sapiens (Human)
P07686 HEXB
HEXB_HUMAN
326 331 FGPINPTLNTTYSFLTTFFK TP 0 Homo sapiens (Human)
P07686 HEXB
HEXB_HUMAN
189 194 DSYGTFTINESTIIDSPRFS TP 0 Homo sapiens (Human)
P07686 HEXB
HEXB_HUMAN
83 88 NFYISHSPNSTAGPSCTLLE TP 0 Homo sapiens (Human)
P48023 FASLG
TNFL6_HUMAN
259 264 TSADHLYVNVSELSLVNFEE TP 1 Homo sapiens (Human)
P48023 FASLG
TNFL6_HUMAN
249 254 SSYLGAVFNLTSADHLYVNV TP 1 Homo sapiens (Human)
P48023 FASLG
TNFL6_HUMAN
183 188 YKKGGLVINETGLYFVYSKV TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
2581 2586 ASFSRALENATRDYFIICPI TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
2294 2299 FIPQNVAPNASVLVFFHNTM TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
2249 2254 RFQAPEPLNWTGSWDASKPR TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
2012 2017 CCTGFGFLNVSQLKGGEVTC TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
1773 1778 MDPSEAWANATCPGVTYDQE TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
1715 1720 IVFSASGANLTDAHLFCLLA TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
1364 1369 LTRERLGVNVTWKSRLEDIP TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
1347 1352 TLVSIPVCNNSSVQVGCLTR TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
1219 1224 SPRCPLPFNASEVVGGTILC TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
946 951 TEEIVSASNSSRFPLGESFL TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
815 820 SYREAASGNFSLFIQSLYEA TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
747 752 RTVQALLSNSSMLPTLSDTY TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
528 533 PLSVGLDSNSSTGTPEAAKK TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
483 488 FLVNVGQFNLSGALGTRGTF TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
197 202 MPVQCKFVNTTDMMIFDLVH TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
109 114 QILLSGYINSTDTSYLPQCQ TP 1 Homo sapiens (Human)
P01266 TG
THYG_HUMAN
75 80 RSCWCVGANGSEVLGSRQPG TP 0 Homo sapiens (Human)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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