| Accession: | |
|---|---|
| Functional site class: | O-Fucosylation site |
| Functional site description: | Site for attachment of a fucose residue to a serine |
| ELM Description: | Site for attachment of a fucose residue to a serine |
| Pattern: | C.{3,5}([ST])C |
| Pattern Probability: | 0.0000462 |
| Present in taxons: | Caenorhabditis elegans Drosophila melanogaster Eumetazoa Homo sapiens Mus musculus |
| Interaction Domain: |
O-FucT (PF10250)
GDP-fucose protein O-fucosyltransferase
(Stochiometry: 1 : 1)
|
 Abstract |
O-Fucose modifications have been described in several different protein contexts including epidermal growth factor-like repeats (important players in several signal transduction systems) and thrombospondin type 1 repeats (in a region involved in cell adhesion). In Notch, a cell-surface signaling receptor required for many developmental events, the O-fucose moieties serve as a substrate for the activity of Fringe, a known modifier of Notch function. |
1 selected reference:
1 GO-Term:
4 Instances for MOD_OFUCOSY
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
| Acc., Gene-, Name | Start | End | Subsequence | Logic | #Ev. | Organism | Notes |
|---|---|---|---|---|---|---|---|
| P98119 Salivary plas URT1_DESRO |
92 | 98 | SCSEPRCFNGGTCWQAVYFS | TP | 1 | Desmodus rotundus (Common vampire bat) | |
| P00750 PLAT TPA_HUMAN |
291 | 296 | RRLTWEYCDVPSCSTCGLRQ | FP | 1 | Homo sapiens (Human) | |
| P00750 PLAT TPA_HUMAN |
91 | 97 | SCSEPRCFNGGTCQQALYFS | TP | 1 | Homo sapiens (Human) | |
| P00749 PLAU UROK_HUMAN |
33 | 39 | VPSNCDCLNGGTCVSNKYFS | TP | 1 | Homo sapiens (Human) |
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement