| Accession: | |
|---|---|
| Functional site class: | NRD cleavage site |
| Functional site description: | N-arginine dibasic convertase (NRD convertase) is a endopeptidase in dibasic sites processing secreted proteins. |
| ELM Description: | N-Arg dibasic convertase (nardilysin) cleavage site (X-|-R-K or R-|-R-X). |
| Pattern: | (.RK)|(RR[^KR]) |
| Pattern Probability: | 0.0074647 |
| Present in taxon: | Metazoa |
| Interaction Domain: |
Peptidase_M16 (PF00675)
Insulinase (Peptidase family M16)
(Stochiometry: 1 : 1)
|
 Abstract |
N-arginine dibasic (NRD) convertase is a metalloendopeptidase primarily cloned from rat brain cortex and testis that cleaves peptide substrates on the N terminus of Arg residues in dibasic stretches. It hydrolyses polypeptides, preferably at -Xaa-+-Arg-Lys-, and less commonly at -Arg-+-Arg-Xaa-, in which Xaa is not Arg or Lys. It has been shown to cleave alpha-neoendorphin, ANF, dynorphin, preproneurotensin and somatostatin. Also there is an evidence for extracellular localization of active NRD. |
3 selected references:
6 GO-Terms:
2 Instances for CLV_NRD_NRD_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
| Acc., Gene-, Name | Start | End | Subsequence | Logic | #Ev. | Organism | Notes |
|---|---|---|---|---|---|---|---|
| P06300 Pdyn PDYN_RAT |
207 | 209 | YKRYGGFLRRIRPKLKWDNQ | TP | 1 | Rattus norvegicus (Norway rat) | |
| P60042 Sst SMS_RAT |
100 | 102 | SNPAMAPRERKAGCKNFFWK | TP | 1 | Rattus norvegicus (Norway rat) |
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement