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|Functional site class:||KDEL retrieving signals|
|Functional site description:||The ER retrieving signals are used to retrieve escaped ER resident proteins from the Golgi apparatus, via a retrograde transport flow involving COPI-coated vesicles.|
|Description:||KDEL retrieving signal is used to recycle ER resident proteins that are carried along with secretory proteins to post-ER compartments. COP I coated vesicles mediate the retrograde transport of soluble ER resident proteins bearing a KDEL-type signal from the Golgi to the ER. This signal is recognized by the KDEL-receptor (ERD2), a seven transmembrane protein found mainly at the cis Golgi, which interacts with COP I. FRET studies have led to a model in which it is the binding of KDEL-bearing cargo to ERD2 which induces its oligomerisation and the formation of the budding complex in the cis Golgi, thus regulating its sorting into COP I-coated vesicles (11703931). KDEL signal is cleaved during the activation of cysteine endopeptidase in the ricinosome of plants, a unique organelle originating from the ER and involved in senescence (11296243).|
|Pattern:||[KRHQSAP][DENQT]EL$ (Probability: 0.0000016)|
|Present in taxons:||Eukaryota|
ER resident proteins such as chaperones or enzymes involved in post-translational modifications need to be retained in the ER compartment. They also can escape the ER compartment and therefore are recycled from the Golgi apparatus through an ER-to-Golgi retrograde transport. Some short linear motifs allow retention and or/retrieval of ER resident proteins that are carried along with secretory proteins to post-ER compartments.
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