Accession: | |
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Functional site class: | Glycosaminoglycan attachment site |
Functional site description: | Proteoglycans are extracellular proteins with glycosaminoglycan chains attached at a serine residue. |
ELM Description: | The glycosaminoglycan attachment site is an exposed serine which accepts transfer of xylose from UDP-xylose to the hydroxyl group by protein xylosyl transferase (EC 2.4.2.26). |
Pattern: | [ED]{0,3}.(S)[GA]. |
Pattern Probability: | 0.0179191 |
Present in taxon: | Metazoa |
Interaction Domains: |
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Abstract |
Proteoglycans are found at the cell surface and in the extracellular matrix. They are important for cell communication, playing a role for example in morphogenesis and development. Mutations in some proteoglycans are associated with an inherited predisposition to cancer. The core protein is modified by attachment of the glycosaminoglycan chain at an exposed serine residue. For heparan sulphate, the process begins by transfer of xylose from UDP-xylose to the serine hydroxyl group by protein xylosyl transferase (EC 2.4.2.26) in the Golgi stack. The system appears to have evolved in metazoan animals. |
6 Instances for MOD_GlcNHglycan
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, Name | Start | End | Subsequence | Logic | #Ev. | Organism | Notes |
---|---|---|---|---|---|---|---|
P50605 sdn-1 SDC_CAEEL |
85 | 88 | DEDGDDVHGSGKPPSSATTK | TP | 2 | Caenorhabditis elegans | |
P50605 sdn-1 SDC_CAEEL |
70 | 73 | RLADIEVNGSGYPTDDEDGD | TP | 2 | Caenorhabditis elegans | |
P18828 Sdc1 SDC1_MOUSE |
46 | 49 | GDDSDNFSGSGTGALPDTLS | TP | 2 | Mus musculus (House mouse) | |
P18828 Sdc1 SDC1_MOUSE |
36 | 39 | NVPPEDQDGSGDDSDNFSGS | TP | 2 | Mus musculus (House mouse) | |
P18828 Sdc1 SDC1_MOUSE |
216 | 219 | GEQDFTFETSGENTAVAAVE | TP | 2 | Mus musculus (House mouse) | |
P18828 Sdc1 SDC1_MOUSE |
206 | 209 | ANQLPAGEGSGEQDFTFETS | TP | 2 | Mus musculus (House mouse) |
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement