The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
export 36 classes as:
ELM IdentifierDescriptionRegExInstancesInstances in PDB
DEG_SCF_SKP2-CKS1_1 Degradation motif recognised by a pre-assembled complex consisting of Skp2 (an F box protein of the SCF E3 ubiquitin ligase) and Cks1, which leads to ubiquitylation and subsequent proteosomal degradation. ..[DE].(T)P.K 3 1
DOC_CKS1_1 Phospho-dependent motif that mediates docking of CDK substrates and regulators to cyclin-CDK-bound Cks1. [MPVLIFWYQ].(T)P.. 8 1
DOC_CYCLIN_1 Substrate recognition site that interacts with cyclin and thereby increases phosphorylation by cyclin/cdk complexes. Predicted proteins should have a CDK phosphorylation site. Also used by cyclin/cdk inhibitors. [RK].L.{0,1}[FYLIVMP] 24 6
MOD_ASX_betaOH_EGF ASX hydroxylation of some EGF domains. C.([DN]).{4,4}[FY].C.C 6 0
MOD_CAAXbox Generic CAAX box prenylation motif (C)[^DENQ][LIVM].$ 2 1
MOD_CDK_SPK_2 Short version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at the [ST] +2 position. ...([ST])P[RK] 18 0
MOD_CDK_SPxK_1 Canonical version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at the [ST]+3 position. ...([ST])P.[KR] 24 1
MOD_CDK_SPxxK_3 Longer version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at position +4 after the phospho-Ser/Thr

...([ST])P..[RK] 25 0
MOD_CK1_1 CK1 phosphorylation site S..([ST])... 2 0
MOD_CK2_1 CK2 phosphorylation site ...([ST])..E 10 0
MOD_CMANNOS Motif for attachment of a mannosyl residue to a tryptophan (W)..W 24 0
MOD_Cter_Amidation Peptide C-terminal amidation (.)G[RK][RK] 0 0
MOD_GlcNHglycan Glycosaminoglycan attachment site [ED]{0,3}.(S)[GA]. 6 0
MOD_GSK3_1 GSK3 phosphorylation recognition site ...([ST])...[ST] 22 0
MOD_LATS_1 The LATS phosphorylation motif is recognised by the LATS kinases for Ser/Thr phosphorylation. Substrates are often found toward the end of the Hippo signalling pathway. H.[KR]..([ST])[^P] 23 0
MOD_NEK2_1 NEK2 phosphorylation motif with preferred Phe, Leu or Met in the -3 position to compensate for less favorable residues in the +1 and +2 position. [FLM][^P][^P]([ST])[^DEP][^DE] 3 0
MOD_NEK2_2 NEK2 phosphorylation motif with specific set of residues in the +1 and +2 position to compensate for less favorable residues in the -3 position. [WYPCAG][^P][^P]([ST])[IFCVML][KRHYF] 0 0
MOD_N-GLC_1 Generic motif for N-glycosylation. It was shown that Trp, Asp, and Glu are uncommon before the Ser/Thr position. Efficient glycosylation usually occurs when ~60 residues or more separate the glycosylation acceptor site from the C-terminus. .(N)[^P][ST].. 156 1
MOD_N-GLC_2 Atipical motif for N-glycosylation site. Examples are Human CD69, which is uniquely glycosylated at typical (Asn-X-Ser/Thr) and atypical (Asn-X-Cys) motifs, beta protein C (N)[^P]C 5 0
MOD_NMyristoyl Generic motif for N-Myristoylation site. ^M{0,1}(G)[^EDRKHPFYW]..[STAGCN][^P] 48 7
MOD_OFUCOSY Site for attachment of a fucose residue to a serine. C.{3,5}([ST])C 4 0
MOD_OGLYCOS Site for attachment of a glucose residue to a serine. C.(S).PC 2 0
MOD_PIKK_1 (ST)Q motif which is phosphorylated by PIKK family members. ...([ST])Q.. 30 0
MOD_PK_1 Phosphorylase kinase phosphorylation site [RK]..(S)[VI].. 1 0
MOD_PKA_1 Main preference for PKA-type AGC kinase phosphorylation. [RK][RK].([ST])[^P].. 25 0
MOD_PKA_2 Secondary preference for PKA-type AGC kinase phosphorylation. .R.([ST])[^P].. 28 0
MOD_PKB_1 PKB Phosphorylation site R.R..([ST])[^P].. 20 1
MOD_PLK Site phosphorylated by the Polo-like kinase. .[DE].([ST])[ILFWMVA].. 2 0
MOD_ProDKin_1 Proline-Directed Kinase (e.g. MAPK) phosphorylation site in higher eukaryotes. ...([ST])P.. 36 0
MOD_SPalmitoyl_2 Class 2 Palmitoylation motif G(C)M[GS][CL][KP]C 2 0
MOD_SPalmitoyl_4 Class 4 palmitoylation motif ^M{0,1}G(C)..S[AKS] 6 0
MOD_SUMO_for_1 Motif recognised for modification by SUMO-1 [VILMAFP](K).E 45 1
MOD_SUMO_rev_2 Inverted version of SUMOylation motif recognized for modification by SUMO-1 [SDE].{0,5}[DE].(K).{0,1}[AIFLMPSTV] 20 0
MOD_TYR_CSK Members of the non-receptor tyrosine kinase Csk family phosphorylate the C-terminal tyrosine residues of the Src family. [TAD][EA].Q(Y)[QE].[GQA][PEDLS] 12 0
MOD_TYR_DYR The kinase activity of the DYRK (dual specificity kinase) is dependent on the autophosphorylation of the YXY motif in the activation loop. ..[RKTC][IVL]Y[TQHS](Y)[IL]QSR 9 0
MOD_WntLipid Palmitoylation site in WNT signalling proteins that is required for correct processing in the endoplasmic reticulum. [ETA](C)[QERK]..F...RWNC[ST] 1 0
CLVHide/Show instances of class type CLV (cleavage sites)
DEGHide/Show instances of class type DEG (degradation sites)
DOCHide/Show instances of class type DOC (docking sites)
LIGHide/Show instances of class type LIG (ligand binding sites)
MODHide/Show instances of class type MOD (post-translational modification sites)
TRGHide/Show instances of class type TRG (targeting sites)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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