The Eukaryote Linear Motif resource for Functional Sites in Proteins
CLV_MEL_PAP_1 172
 
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Functional site class: Melanisation activation site
Functional site description: Prophenoloxidase activation cleavage site is cut by the PPAE enzyme which is also inhibited by some serpins. Activation leads to melanisation of invasive organisms.
ELMs: CLV_MEL_PAP_1
Description: Prophenoloxidase-activation proteinase is Anthropoda specific proprotein convertase. It activates the melanisation process, which is a common response to parasite entry in invertebrate animals. Similar to several other proprotein convertases it cleaves polypeptide at carboxy-site of arginine. Note that this cleavage usually occurs at unstructured N-terminal end of target proteins.
Pattern: [ILV]..[R][VF][GS]. (Probability: 0.0001054)
Present in taxons: Arthropoda

o See 12 Instances for CLV_MEL_PAP_1


o Abstract

Prophenoloxidase activation cleavage site is cut by the PPAE enzyme which is also inhibited by some serpins. Activation leads to melanisation of invasive organisms.

o 3 selected references:

o 3 GO-Terms:

o 12 Instances for CLV_MEL_PAP_1
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
Q27598_DROME 49 55 RNDTEEVGNRFSKDVDLKIP true positive --- Drosophila melanogaster (Fruit fly)
Q8I6K1_HOLDI 47 53 KAIGVQVSNRFGEETKSKIP true positive --- Holotrichia diomphalia
Q8I6K2_HOLDI 48 54 KNVAVEISNRFGEDDSETVT true positive --- Holotrichia diomphalia
O77002_HYPCU 48 54 KFATNVIANRFGNDATRTIP true positive --- Hyphantria cunea (Fall webworm moth)
Q9Y0B4_SARBU 47 53 RPIGSEVQSRFGEKAEKRIP true positive --- Neobellieria bullata (Grey fleshfly)
Q8MUI4_PENMO 41 47 DEAPPSVATRVGVSPSVNLP true positive --- Penaeus monodon (Black tiger shrimp)
Q16IZ3_AEDAE 48 54 RAIGQSLQTRFSTNISTRVP true positive --- Aedes aegypti (Yellow fever mosquito)
Q9BLG6_BOMMO 48 54 ANNGIELNNRFGDDASEKIP true positive --- Bombyx mori (Domestic silkworm)
Q9GYX9_9DIPT 49 55 RAIGAELQNRFSNDAEQRIP true positive --- Armigeres subalbatus
Q86MV4_APIME 48 54 RSVATQVFNRFGDDTESKLP true positive --- Apis mellifera (Honey bee)
O76951_ANOGA 46 52 RPIGPEIQNRFGENAEERIP true positive --- Anopheles gambiae (African malaria mosquito)
O97047_TENMO 47 53 KPLGVALTNRFGEDADERID true positive --- Tenebrio molitor (Yellow mealworm)

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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