CLV_MEL_PAP_1
ELM server details
ELM
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Functional site class:
 Melanisation activation site
Functional site description:
 Prophenoloxidase activation cleavage site is cut by the PPAE enzyme which is also inhibited by some serpins. Activation leads to melanisation of invasive organisms.
ELM(s): CLV_MEL_PAP_1
CLV_MEL_PAP_1 description: Prophenoloxidase-activation proteinase is Anthropoda specific proprotein convertase. It activates the melanisation process, which is a common response to parasite entry in invertebrate animals. Similar to several other proprotein convertases it cleaves polypeptide at carboxy-site of arginine. Note that this cleavage usually occurs at unstructured N-terminal end of target proteins.
Pattern: [ILV]..[R][VF][GS].
Present in taxon(s): Arthropoda  
Not represented in taxon(s):

o See instances for CLV_MEL_PAP_1


o Abstract

Prophenoloxidase activation cleavage site is cut by the PPAE enzyme which is also inhibited by some serpins. Activation leads to melanisation of invasive organisms.

o Selected references

Soderhall K, Cerenius L
Role of the prophenoloxidase-activating system in invertebrate immunity.
Curr Opin Immunol 1998 Feb;10(1) : 23-8.
PMID: 9523106

Zhu Y, Wang Y, Gorman MJ, Jiang H, Kanost MR
Manduca sexta serpin-3 regulates prophenoloxidase activation in response to infection by inhibiting prophenoloxidase-activating proteinases.
J Biol Chem 2003 Nov 21;278(47) : 46556-64.
PMID: 12966082

o This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process
  proteolysis and peptidolysis
Cellular Component
  extracellular
Molecular Function
  defense/immunity protein activity

 

o Instances for CLV_MEL_PAP_1

SequencePositionSubsequence
(Click for evidence information)		PDBGene NameProtein DescriptionOrganism
Q8MUI4_PENMO 41-47 EAPPSVATRVGVSPSVNL - - Prophenoloxidase. Penaeus monodon (Penoeid shrimp).
Q8I6K1_HOLDI 47-53 AIGVQVSNRFGEETKSKI - Name=proPO-II; Prophenoloxidase-II. Holotrichia diomphalia (Korean black chafer).
Q8I6K2_HOLDI 48-54 NVAVEISNRFGEDDSETV - Name=proPO-I; Prophenoloxidase-I. Holotrichia diomphalia (Korean black chafer).
O77002_HYPCU 48-54 FATNVIANRFGNDATRTI - Name=HcProPO; Prophenoloxidase. Hyphantria cunea (Fall webworm).
Q9Y0B4_SARBU 47-53 PIGSEVQSRFGEKAEKRI - Name=Ppo1; Prophenoloxidase. Sarcophaga bullata (Grey flesh fly) (Neobellieria bullata).
Q16IZ3_AEDAE 48-54 AIGQSLQTRFSTNISTRV - ORFNames=AaeL_AAEL013496; Prophenoloxidase. Aedes aegypti (Yellowfever mosquito).
Q9BLG6_BOMMO 48-54 NNGIELNNRFGDDASEKI - - Prophenoloxidase-2s. Bombyx mori (Silk moth).
Q9GYX9_9DIPT 49-55 AIGAELQNRFSNDAEQRI - - Prophenoloxidase II (EC 1.14.18.1). Armigeres subalbatus.
Q86MV4_APIME 48-54 SVATQVFNRFGDDTESKL - - Prophenoloxidase. Apis mellifera (Honeybee).
O76951_ANOGA 46-52 PIGPEIQNRFGENAEERI - Name=AgProPO; Prophenoloxidase. Anopheles gambiae (African malaria mosquito).
O97047_TENMO 47-53 PLGVALTNRFGEDADERI - Name=ppo-5; Prophenoloxidase. Tenebrio molitor (Yellow mealworm).
Q27598_DROME 49-55 NDTEEVGNRFSKDVDLKI - Name=Bc; ORFNames=CG5779; Pro-phenol oxidase A1 (EC 1.14.18.1). Drosophila melanogaster (Fruit fly).