The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
export 22 classes as:
ELM IdentifierDescriptionRegExInstancesInstances in PDB
LIG_Pex14_3 Motif in Pex5 interacting with the N-terminal domain (NTD) of Pex14 LV.EF[LM] 1 1
LIG_Pex14_4 Fungal motif in Pex5 interacting with the N-terminal domain of Pex14 MM[NDE][EDNAG]F[LMA] 0 0
TRG_AP2beta_CARGO_1 AP-2 beta appendage platform subdomain (top surface) binding motif used in targeting cargo for internalisation. [DE].{1,2}F[^P][^P][FL][^P][^P][^P]R 4 2
TRG_Cilium_Arf4_1 The QVxPx motif is located in the cytoplasmatic tails of vesicular cargoes. It allows the interaction with proteins that permit the vesicle budding from the trans-Golgi-network and its posterior transport to the plasma membrane of the cilia. QV.P.$ 1 0
TRG_Cilium_RVxP_2 The RVxPx motif is located in the cytoplasmatic tails of vesicular cargoes. It allows the interaction with proteins that permit the vesicle budding from the trans-Golgi-network and its posterior transport to the plasma membrane of the cilia RV.P. 2 0
TRG_ENDOCYTIC_2 Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex Y..[LMVIF] 15 1
TRG_ER_diArg_1 The di-Arg ER retention motif is defined by two consecutive arginine residues (RR) or with a single residue insertion (RXR). The motif is completed by an adjacent hydrophobic/arginine residue which may be on either side of the Arg pair. ([LIVMFYWPR]R[^YFWDE]{0,1}R)|(R[^YFWDE]{0,1}R[LIVMFYWPR]) 27 0
TRG_ER_diLys_1 ER retention and retrieving signal found at the C-terminus of type I ER membrane proteins (cytoplasmic in this topology). Di-Lysine signal is responsible for COPI-mediated retrieval from post-ER compartments. K.{0,1}K.{2,3}$ 14 0
TRG_ER_FFAT_1 VAP-A/Scs2 MSP-domain binding FFAT (diphenylalanine [FF] in an Acidic Tract) motif [DE].{0,4}E[FY][FYK]D[AC].[ESTD] 20 1
TRG_ER_KDEL_1 Golgi-to-ER retrieving signal found at the C-terminus of many ER soluble proteins. It interacts with the KDEL receptor which in turns interacts with components of the coatomer (COP I). [KRHQSAP][DENQT]EL$ 12 0
TRG_Golgi_diPhe_1 ER to Golgi anterograde transport signal found at the C-terminus of type I ER-CGN integral membrane cargo receptors (cytoplasmic in this topology), it binds to COPII. Q.{6,6}FF.{6,7}$ 11 0
TRG_LysEnd_APsAcLL_1 Sorting and internalisation signal found in the cytoplasmic juxta-membrane region of type I transmembrane proteins. Targets them from the Trans Golgi Network to the lysosomal-endosomal-melanosomal compartments. Interacts with adaptor protein (AP) complexes [DERQ]...L[LVI] 16 1
TRG_LysEnd_APsAcLL_3 Sorting signal found in the cytoplasmic juxta-membrane region of type I transmembrane lysosomal, endosomal and melanosomal proteins. Based on experimental evidence and alignments, this very specific ELM represents the best combination for AP3 binding. [DET]E[RK].PL[LI] 3 0
TRG_LysEnd_GGAAcLL_1 Sorting signal directing type I transmembrane proteins from the Trans Golgi Network (TGN) to the lysosomal-endosomal compartment. It is found near the C-terminus and interacts with the VHS domain of GGAs adaptor proteins. D..LL.{1,2}$ 6 3
TRG_LysEnd_GGAAcLL_2 Internal acidic di Leucine motif found in GGA 1 and 3. It binds to their VHS domains in an autoinhibitory manner. Cycles of phosphorylation-dephosphorylation of upstream Ser regulate the autoinhibitory binding and therefore the function of GGA 1/3. S[LW]LD[DE]EL[LM] 4 0
TRG_NES_CRM1_1 Some proteins re-exported from the nucleus contain a Leucine-rich nuclear export signal (NES) binding to the CRM1 exportin protein. ([DEQ].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DE])|([DE].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DEQ]) 18 3
TRG_NLS_Bipartite_1 Bipartite variant of the classical basically charged NLS. [KR][KR].{7,15}[^DE]((K[RK])|(RK))(([^DE][KR])|([KR][^DE]))[^DE] 9 4
TRG_NLS_MonoCore_2 Monopartite variant of the classical basically charged NLS. Strong core version. [^DE]((K[RK])|(RK))[KRP][KR][^DE] 17 1
TRG_NLS_MonoExtC_3 Monopartite variant of the classical basically charged NLS. C-extended version. [^DE]((K[RK])|(RK))(([^DE][KR])|([KR][^DE]))(([PKR])|([^DE][DE])) 18 2
TRG_NLS_MonoExtN_4 Monopartite variant of the classical basically charged NLS. N-extended version. (([PKR].{0,1}[^DE])|([PKR]))((K[RK])|(RK))(([^DE][KR])|([KR][^DE]))[^DE] 26 2
TRG_PTS1 Generic PTS1 ELM for all eukaryotes (.[SAPTC][KRH][LMFI]$)|([KRH][SAPTC][NTS][LMFI]$) 5 1
TRG_PTS2 Generic PTS2 pattern for all eukaryotes (except lineages which have lost it) ^.{1,40}R[^P][^P][^P][LIV][^P][^P][HQ][LIF] 2 2
CLVHide/Show instances of class type CLV (cleavage sites)
DEGHide/Show instances of class type DEG (degradation sites)
DOCHide/Show instances of class type DOC (docking sites)
LIGHide/Show instances of class type LIG (ligand binding sites)
MODHide/Show instances of class type MOD (post-translational modification sites)
TRGHide/Show instances of class type TRG (targeting sites)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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