| ELM Identifier | Description | RegEx | Instances | Instances in PDB | Articles.ELM |
|---|---|---|---|---|---|
| DOC_AGCK_PIF_1 | The DOC_AGCK_PIF_1 motif contains a phosphorylatable serine/threonine residue that allows fine-tuning of the affinity of the motif for the PIF pocket, with the phosphorylated motif showing a higher affinity. | F..[FWY][ST][FY] | 10 | 1 | articles.ELM |
| DOC_AGCK_PIF_2 | In the DOC_AGCK_PIF_2 motif the phosphorylatable serine/threonine residue is replaced by an acidic aspartate or glutamate residue. | F..[FWY][DE][FY] | 5 | 0 | articles.ELM |
| DOC_AGCK_PIF_3 | The DOC_AGCK_PIF_3 variant consists only of the first two core aromatic residues preceding the phosphorylatable or acidic site in the other variants, and the latter of these two aromatic residues is the C-terminal residue of the kinase sequence. | F..F$ | 5 | 1 | articles.ELM |
| DOC_ANK_TNKS_1 | The Tankyrase binding motif interacts with the ankyrin repeat domain region in Tankyrase-1 and Tankyrase-2 to facilitate the PARsylation of the target proteins. | .R..[PGAV][DEIP]G. | 17 | 5 | articles.ELM |
| DOC_CDC14_PxL_1 | The PxL substrate docking motif enhances the Cdc14 phosphatase–substrate interaction and promotes subsequent dephosphorylation. |
[FYLIM]..[YVILA]P.L.. | 10 | 2 | articles.ELM |
| DOC_CKS1_1 | Phospho-dependent motif that mediates docking of CDK substrates and regulators to cyclin-CDK-bound Cks1. | [MPVLIFWYQ].(T)P.. | 8 | 1 | articles.ELM |
| DOC_CYCLIN_D_Helix_1 | The Cyclin D Helical docking motif mediates binding of substrates to a site on Cyclin D different from the hydrophobic pocket and enhances substrate phosphorylation by CyclinD/Cdk4-6 complexes. | [FLV][^P][^P][KR]L[^P][^P][LMIV][^P][^P][^P]R | 3 | 0 | articles.ELM |
| DOC_CYCLIN_RevRxL_6 | The hydrophobic patch (hp) of Cyclin A2 can bind an RxL-like motif the reverse orientation. | [EDST].{0,3}[FL].[ILV][^D][RK][^PD][^EDWNG]((.{0,3}[KRH])|.) | 1 | 1 | articles.ELM |
| DOC_CYCLIN_RxL_1 | Both fungal and mammalian S-phase Cyclin/CDK complexes recognize specific RxL docking motifs in their target proteins. | (.|([KRH].{0,3}))[^EDWNSG][^D][RK][^D]L.{0,1}[FL].{0,3}[EDST] | 31 | 7 | articles.ELM |
| DOC_CYCLIN_yClb1_LxF_4 | The LxF motif found in budding yeasts serves as a docking site for mitotic cyclin-CDK complexes (M-CDK). It is found in both regulators and mitotic phosphorylation target proteins. | (P.[KR]L.F)|(.N[KR]L.F)|(.N.L.F[LMIVFY]) | 13 | 0 | articles.ELM |
| DOC_CYCLIN_yClb3_PxF_3 | The hydrophobic patch (hp) of the G2 phase cyclin from budding yeast, Clb3, binds a specific PxF docking motif on regulators and target proteins. | (PP..P.F)|(P..P.F..[KR]) | 4 | 0 | articles.ELM |
| DOC_CYCLIN_yClb5_NLxxxL_5 | Cyclin hydrophobic patch docking motif NLxxxL specific for S-phase cyclins Clb5 and Clb6 in budding yeasts. | ([ILVMF]...NL...L)|([KR].{0,2}NL...L) | 5 | 0 | articles.ELM |
| DOC_CYCLIN_yCln2_LP_2 | The budding yeast G1/S cyclins Cln1 and 2 bind a specific leucine- and proline-rich (LP) docking motif on G1-specific target proteins. | (L[MLIV]PP)|(((L[LMIV]PA)|(L..P))[ILMVAFYW].[MLIVFHPAY]) | 18 | 0 | articles.ELM |
| DOC_GSK3_Axin_1 | Docking motif present in Axin protein binds the GSK-3β kinase and aids the phosphorylation of components in the APC destruction complex. | V[ED]P[^P][RK]FA[^P]ELI[^P]RLE[^P][VIL] | 6 | 1 | articles.ELM |
| DOC_MAPK_DCC_7 | A kinase docking motif mediating interaction towards the ERK1/2 and p38 subfamilies of MAP kinases | [RK].{2,4}[LIVP]P.[LIV].[LIVMF]|[RK].{2,4}[LIVP].P[LIV].[LIVMF] | 11 | 2 | articles.ELM |
| DOC_MAPK_FxFP_2 | MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motif that help to regulate specific interaction in the MAPK cascade. | F.[FY]P | 15 | 1 | articles.ELM |
| DOC_MAPK_gen_1 | MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motif that help to regulate specific interaction in the MAPK cascade. The classic motif approximates (R/K)xxxx#x# where # is a hydrophobic residue. | [KR]{0,2}[KR].{0,2}[KR].{2,4}[ILVM].[ILVF] | 15 | 0 | articles.ELM |
| DOC_MAPK_GRA24_9 | A kinase docking motif that mediates interaction towards the ERK1/2 and p38 subfamilies of MAP kinases | [LIV][^P][^P][RK][RK]G.{3,6}[LIVP]P.[LIV].[LIVMF]|[LIV][^P][^P][RK][RK]G.{3,6}[LIVP].P[LIV].[LIVMF] | 2 | 1 | articles.ELM |
| DOC_MAPK_HePTP_8 | A kinase docking motif that interacts with the ERK1/2 and p38 subfamilies of MAP kinases. | ([LIV][^P][^P][RK]....[LIVMP].[LIV].[LIVMF])|([LIV][^P][^P][RK][RK]G.{4,7}[LIVMP].[LIV].[LIVMF]) | 10 | 3 | articles.ELM |
| DOC_MAPK_JIP1_4 | A shorter D site specifically recognized by the JNK kinases | [RK]P[^P][^P]L.[LIVMF] | 29 | 2 | articles.ELM |
| DOC_MAPK_MEF2A_6 | A kinase docking motif that mediates interaction towards the ERK1/2 and p38 subfamilies of MAP kinases. | [RK].{2,4}[LIVMP].[LIV].[LIVMF] | 27 | 2 | articles.ELM |
| DOC_MAPK_NFAT4_5 | An extended D site specifically recognized by the JNK kinases | [RK][^P][^P][LIM].L.[LIVMF]. | 17 | 1 | articles.ELM |
| DOC_MAPK_RevD_3 | Reverse (C to N direction) of the classical MAPK docking motif DOC_MAPK_gen_1 with an often extended linker region of the bipartite motif. | [LIVMPFA].[LIV].{1,2}[LIVMP].{4,6}[LIV]..[RK][RK] | 6 | 3 | articles.ELM |
| DOC_MIT_MIM_1 | C-terminal LxxR[FL]xxL based type 1 MIT interacting motif (MIM1) that docks at the MIT domain present in some ESCRT-III proteins. | ((F[^P][^P])|([DE].{0,2}))L[^P][^P]R[FL][^P][^P]L[KR]{0,2} | 5 | 5 | articles.ELM |
| DOC_PIKK_1 | DOC_PIKK_1 motif is located in the C terminus of Nbs1 and its homologues and interacts with PIKK family members. | [DEN][DEN].{2,3}[ILMVA][DEN][DEN]L | 4 | 0 | articles.ELM |
| DOC_PP1_MyPhoNE_1 | Docking motif that binds to the catalytic subunit of Protein Phosphatase 1 (PP1c) and is generally located N-terminal to an RVxF motif. | R[^P][DEQ]Q[VIL]([RK][^P]|[^P][RK])[YW] | 9 | 1 | articles.ELM |
| DOC_PP1_RVXF_1 | Protein phosphatase 1 catalytic subunit (PP1c) interacting motif binds targeting proteins that dock to the substrate for dephosphorylation. The motif defined is [RK]{0,1}[VI][^P][FW]. | ..[RK].{0,1}[VIL][^P][FW]. | 19 | 4 | articles.ELM |
| DOC_PP1_SILK_1 | Protein phosphatase 1 catalytic subunit (PP1c) interacting motif that often cooperates with and is located N-terminal to the RVXF motif to dock proteins to PP1c. | .[GS]IL[KR][^DE] | 14 | 1 | articles.ELM |
| DOC_PP2A_B56_1 | Docking site required for the regulatory subunit B56 of PP2A for protein dephosphorylation. | ([LMFYWIC]..I.E)|(L..[IVLWC].E). | 18 | 2 | articles.ELM |
| DOC_PP2B_LxvP_1 | Docking motif in calcineurin substrates that binds at the interface of the catalytic CNA and regulatory CNB subunits. | L.VP | 50 | 1 | articles.ELM |
| DOC_PP2B_PxIxIT_1 | PxIxIT docking motif in calcineurin substrates that binds the catalytic CNA subunit. | P[^P][ILVF][^P][ILVF][TSHDEQNKR] | 27 | 4 | articles.ELM |
| DOC_PP4_FxxP_1 | The FxxP-like docking motif recognized by the EVH1 domains of the PPP4R3 regulatory subunits of the PP4 holoenzyme | F..P | 15 | 0 | articles.ELM |
| DOC_PP4_MxPP_1 | The MxPP-like docking motif recognized by the EVH1 domains of the PPP4R3 regulatory subunits of the PP4 holoenzyme | M.PP | 2 | 0 | articles.ELM |
| DOC_PUB_PIM_1 | The PIM motif binds to the PUB domain of proteins involved in the regulation of ubiquitination | .D[LM]Y. | 2 | 2 | articles.ELM |
| DOC_RSK_DDVF_1 | This short, partly acid [DE]-[DE]-V-F motif binds to the surface region of the RSK N-terminal kinase domain | [DE][DE]VF | 5 | 1 | articles.ELM |
| DOC_SPAK_OSR1_1 | SPAK/OSR1 kinase binding motif acts as a docking site which aids the interaction with their binding partners including the upstream activators and the phosphorylated substrates. | RF[^P][IV]. | 13 | 1 | articles.ELM |
| DOC_USP7_MATH_1 | The USP7 MATH domain binding motif variant based on the MDM2 and p53 interactions. | [PA][^P][^FYWIL]S[^P] | 10 | 6 | articles.ELM |
| DOC_USP7_MATH_2 | The USP7 MATH domain binding motif variant based on the EBV EBNA1 interaction. | P.E[^P].S[^P] | 1 | 1 | articles.ELM |
| DOC_USP7_UBL2_3 | The USP7 CTD domain binding motif variant based on the ICP0 and DNMT1 interactions | K...K | 7 | 2 | articles.ELM |
| DOC_WD40_RPTOR_TOS_1 | The TOR pathway adaptor protein Raptor links the mTOR kinase to the TOS motif containing substrates 4E-BP1 and S6-beta kinases. Proteins with TOR motif (e.g. 4E-BP1, S6KB1) participate in the transcription mechanism. |
F[EDQS][MILV][ED][MILV]((.{0,1}[ED])|($)) | 5 | 0 | articles.ELM |
| DOC_WW_Pin1_4 | The Class IV WW domain interaction motif is recognised primarily by the Pin1 phosphorylation-dependent prolyl isomerase. | ...([ST])P. | 96 | 1 | articles.ELM |
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Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
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ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement