ELM - instance LIG_SH3_2 in sequence P01106 at position 60

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002132	P01106 MYC MYC_HUMAN	60	65	FELLPTPPLSPSRRSGLCSP	TP	1MV0	Homo sapiens (Human)	439

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0077	nuclear magnetic resonance	in vitro	Pineda-Lucena,2005	support	certain	InteractionDetection FeatureDetection
experimental	MI:0018	two hybrid	in vivo	Pineda-Lucena,2005	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:

SWTI000182:

Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).
SWTI000324:

An intramolecular interaction of an SH3 binding motif, encoded by exon 12A, in Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1) with the SH3 domain of Bin1 prevents interaction of the Bin1 SH3 domain with the SH3 binding motif of Myc proto-oncogene protein (MYC).

Pathways

KEGG: The sequence P01106 is implicated in the following 34 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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