Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI002132 | P01106 MYC MYC_HUMAN |
60 | 65 | FELLPTPPLSPSRRSGLCSP | TP |
1MV0 |
Homo sapiens (Human) | 439 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0077 | nuclear magnetic resonance | in vitro | Pineda-Lucena,2005 | support | certain | InteractionDetection FeatureDetection |
experimental | MI:0018 | two hybrid | in vivo | Pineda-Lucena,2005 | support | certain | InteractionDetection |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000182:
Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).
-
SWTI000324:
An intramolecular interaction of an SH3 binding motif, encoded by exon 12A, in Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1) with the SH3 domain of Bin1 prevents interaction of the Bin1 SH3 domain with the SH3 binding motif of Myc proto-oncogene protein (MYC).
Pathways
KEGG: The sequence P01106 is implicated in the following 34 Pathways: (color codes: This sequence=red, interacting sequence=orange)- Acute myeloid leukemia
- Bladder cancer
- Breast cancer
- Cell cycle
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis receptor activation
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- Epstein Barr virus infection
- ErbB signaling pathway
- Gastric cancer
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human T cell leukemia virus 1 infection
- Human cytomegalovirus infection
- JAK STAT signaling pathway
- Kaposi sarcoma associated herpesvirus infection
- MAPK signaling pathway
- MicroRNAs in cancer
- PI3K Akt signaling pathway
- Pathways in cancer
- Proteoglycans in cancer
- Salmonella infection
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- TGF beta signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Transcriptional misregulation in cancer
- Wnt signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement