ELM - instance TRG_ENDOCYTIC_2 in sequence P09793 at position 201

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002109	P09793 Ctla4 CTLA4_MOUSE	201	204	RSPLTTGVYVKMPPTEPECE	TP	---	Mus musculus (House mouse)	223

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Shiratori,1997	support	certain	InteractionDetection
experimental	MI:0018	two hybrid	in vivo	Shiratori,1997	support	certain	InteractionDetection
experimental	MI:0405	competition binding	in vitro	Shiratori,1997	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Shiratori,1997	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000280:

Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.

Pathways

KEGG: The sequence P09793 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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