ELM - instance DOC_ANK_TNKS_1 in sequence P78314 at position 414

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002044	P78314 SH3BP2 3BP2_HUMAN	414	421	PQLPHLQRSPPDGQSFRSFS	TP	---	Homo sapiens (Human)	561

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Guettler,2011	support	certain
experimental	MI:0053	fluorescence polarization spectroscopy	in vitro	Guettler,2011	support	certain	InteractionDetection
experimental	MI:0005	alanine scanning	in vivo/in vitro/in silico	Guettler,2011	support	certain	FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Guettler,2011	support	certain	InteractionDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(Q9H2K2) TNKS2_HUMAN	PF00023 (Ank) Ankyrin repeat	525	557		[mitab][xml]

Pathways

KEGG: The sequence P78314 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Diseases

Sequence Variation VAR_013260 (Pos 418) has been implicated in Cherubism (O MIM:118400).
Sequence Variation VAR_013261 (Pos 418) has been implicated in Cherubism (O MIM:118400).
Sequence Variation VAR_013262 (Pos 420) has been implicated in Cherubism (O MIM:118400).
Sequence Variation VAR_013263 (Pos 420) has been implicated in Cherubism (O MIM:118400).
Sequence Variation VAR_013259 (Pos 418) has been implicated in Cherubism (O MIM:118400).
Sequence Variation VAR_013258 (Pos 415) has been implicated in Cherubism (O MIM:118400).
Sequence Variation VAR_013257 (Pos 415) has been implicated in Cherubism (O MIM:118400).

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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