The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI000914 P25054 APC
APC_HUMAN
163 176 AQLQNLTKRIDSLPLTENFS TP 1M5I  
pdb:1M5I
Homo sapiens (Human) 2843

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0114 x-ray crystallography in vitro Tickenbrock,2002 contradict unlikely InteractionDetection FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Tickenbrock,2002 support likely FeatureDetection
experimental MI:0405 competition binding in vitro Neufeld,2000 support likely InteractionDetection

o  Pathways

The sequence P25054 is implicated in the following 10 Pathways: (color codes: This sequence=red, interacting sequence=orange)

o  Diseases

  • Sequence Variation VAR_005032 (Pos 171) has been implicated in Familial Adenomatous Polyposis 1; Fap1 (OMIM:175100).
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org