| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI000914 | P25054 APC APC_HUMAN |
163 | 176 | AQLQNLTKRIDSLPLTENFS | TP |
1M5I 
|
Homo sapiens (Human) | 2843 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0114 | x-ray crystallography | in vitro | Tickenbrock,2002 | contradict | unlikely | InteractionDetection FeatureDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Tickenbrock,2002 | support | likely | FeatureDetection |
| experimental | MI:0405 | competition binding | in vitro | Neufeld,2000 | support | likely | InteractionDetection |
Pathways
- Alzheimer disease
- Basal cell carcinoma
- Breast cancer
- Colorectal cancer
- Cushing syndrome
- Endometrial cancer
- Gastric cancer
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human papillomavirus infection
- MicroRNAs in cancer
- Pathways in cancer
- Pathways of neurodegeneration multiple diseases
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
- Wnt signaling pathway
Diseases
- Sequence Variation VAR_005032 (Pos 171) has been implicated in Familial Adenomatous Polyposis 1; Fap1 (OMIM:175100).
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement