The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003227 P49768 PSEN1
PSN1_HUMAN
351 358 DSHLGPHRSTPESRAAVQEL TP --- Homo sapiens (Human) 467

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0517 radiolabel in vitro Lau,2002 support certain
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Lau,2002 support certain FeatureDetection
experimental MI:0424 protein kinase assay in vitro Lau,2002 support certain InteractionDetection
experimental MI:0424 protein kinase assay in vivo Lau,2002 support certain InteractionDetection
experimental MI:0413 electrophoretic mobility shift assay Lau,2002 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q00535) CDK5_HUMAN PF00069 (Pkinase)
Protein kinase domain
4 286 [mitab][xml]

o  Pathways

The sequence P49768 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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