| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002041 | P20963 CD247 CD3Z_HUMAN |
69 | 86 | QNQLYNELNLGRREEYDVLD | TP | --- | Homo sapiens (Human) | 164 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Sunder-Plassmann,1997 | support | likely | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Sunder-Plassmann,1997 | support | likely | FeatureDetection |
| experimental | MI:0405 | competition binding | in vitro | Bu,1995 | support | likely | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P43405) KSYK_HUMAN | PF00017
(SH2)
SH2 domain |
15 | 92 | [mitab][xml] | |
| (P43405) KSYK_HUMAN | PF00017
(SH2)
SH2 domain |
168 | 244 | [mitab][xml] | |
| (P43403) ZAP70_HUMAN | PF00017
(SH2)
SH2 domain |
10 | 87 | [mitab][xml] | |
| (P43403) ZAP70_HUMAN | PF00017
(SH2)
SH2 domain |
163 | 239 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000344:
Phosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
Pathways
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement