| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002040 | P07766 CD3E CD3E_HUMAN |
185 | 202 | PNPDYEPIRKGQRDLYSGLN | TP |
1A81 
|
Homo sapiens (Human) | 207 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Bu,1995 | support | certain | |
| experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Kesti,2007 | support | certain | |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Bu,1995 | support | certain | FeatureDetection |
| experimental | MI:0107 | surface plasmon resonance | in vitro | Bu,1995 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0114 | x-ray crystallography | in vitro | Futterer,1998 | support | certain | InteractionDetection FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P43405) KSYK_HUMAN | PF00017
(SH2)
SH2 domain |
15 | 92 | 0.0214/0.0272 | [mitab][xml] |
| (P43405) KSYK_HUMAN | PF00017
(SH2)
SH2 domain |
168 | 244 | 0.0214/0.0272 | [mitab][xml] |
| (P43403) ZAP70_HUMAN | PF00017
(SH2)
SH2 domain |
10 | 87 | [mitab][xml] | |
| (P43403) ZAP70_HUMAN | PF00017
(SH2)
SH2 domain |
163 | 239 | [mitab][xml] |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000287:
Phosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).
-
SWTI000346:
Phosphorylation of Y188 and Y199 in the ITAM motif of T-cell surface glycoprotein CD3 epsilon chain (CD3E) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).
Pathways
- Chagas disease
- Epstein Barr virus infection
- Hematopoietic cell lineage
- Human T cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Measles
- PD L1 expression and PD 1 checkpoint pathway in cancer
- Primary immunodeficiency
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement