The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI000016 P25942 CD40
TNR5_HUMAN
231 239 APHPKQEPQEINFPDDLPGS TP 1LB6  
Homo sapiens (Human) 277

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0065 isothermal titration calorimetry in vitro Ye,2002 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Ye,2002 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Ye,2002 support certain InteractionDetection FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Pullen,1999 support certain FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9Y4K3) TRAF6_HUMAN IPR037309 (TNF receptor-associated factor 6, MATH domain)
TNF receptor-associated factor 6 (TRAF6) regulates a diverse array of processes, including adaptive immunity, innate immunity, bone metabolism and tissue development
351 500 84.0/84.0 [mitab][xml]

o  Pathways

KEGG: The sequence P25942 is implicated in the following 17 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org