The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004701 P47741 Tnfrsf4
257 260 CWGNSFRTPIQEEHTDAHFT TP --- Mus musculus (House mouse) 272

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0074 mutation analysis in vivo/in vitro Arch,1998 support certain FeatureDetection
experimental MI:0113 western blot in vitro Arch,1998 support certain ParticipantIdentification FeatureDetection
experimental MI:0018 two hybrid in vivo Arch,1998 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q13077) TRAF1_HUMAN IPR037306 (TNF receptor-associated factor 1, MATH domain)
TNF receptor-associated factor 1 (TRAF1) plays a role in the regulation of cell survival and apoptosis
267 413 [mitab][xml]
(Q12933) TRAF2_HUMAN IPR037305 (TNF receptor-associated factor 2, MATH domain)
TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis
334 497 [mitab][xml]
(Q13114) TRAF3_HUMAN IPR037304 (TRAF3, MATH domain)
Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated p...
378 563 [mitab][xml]
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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