The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
LIG_SH3_CIN85_PxpxPR_1

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004428 Q13191 CBLB
CBLB_HUMAN 		906 911 SQAPARPPKPRPRRTAPEIH TP 2BZ8  
2J6F  
Homo sapiens (Human) 982

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0113 western blot in vitro Moncalian,2006 support certain ParticipantIdentification FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Moncalian,2006 support certain InteractionDetection
experimental MI:0007 anti tag coimmunoprecipitation in vivo Moncalian,2006 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Moncalian,2006 support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Moncalian,2006 support certain
experimental MI:0114 x-ray crystallography in vitro Moncalian,2006 support certain InteractionDetection FeatureDetection
experimental MI:0506 over expressed level in vivo Moncalian,2006 support certain
experimental MI:0077 nuclear magnetic resonance in vitro Ceregido,2013 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Ceregido,2013 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Jozic,2005 support likely InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Jozic,2005 support likely FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Jozic,2005 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Jozic,2005 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Jozic,2005 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Jozic,2005 support certain InteractionDetection
experimental MI:0113 western blot in vitro Kowanetz,2003 support likely ParticipantIdentification FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Kowanetz,2003 support likely InteractionDetection
experimental MI:0065 isothermal titration calorimetry in vitro Kowanetz,2003 support likely InteractionDetection
experimental MI:0077 nuclear magnetic resonance in vitro Ababou,2009 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Ababou,2009 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Szymkiewicz,2002 support likely InteractionDetection
experimental MI:0018 two hybrid in vivo Szymkiewicz,2002 support likely InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9Y5K6) CD2AP_HUMAN PF14604 (SH3_9)
Variant SH3 domain 		6 55 0.017/0.21 [mitab][xml]
(Q96B97) SH3K1_HUMAN PF14604 (SH3_9)
Variant SH3 domain 		6 54 1.6/2.0 [mitab][xml]
(Q96B97) SH3K1_HUMAN PF14604 (SH3_9)
Variant SH3 domain 		105 153 2.7/2.7 [mitab][xml]
(Q96B97) SH3K1_HUMAN PF14604 (SH3_9)
Variant SH3 domain 		274 324 14.5/14.5 [mitab][xml]

o  Pathways

KEGG: The sequence Q13191 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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