The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004426 P06729 CD2
CD2_HUMAN
327 332 VHQQKGPPLPRPRVQPKPPH TP 2J6O  
2J7I  
Homo sapiens (Human) 351

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0113 western blot in vitro Moncalian,2006 support certain ParticipantIdentification FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Moncalian,2006 support certain InteractionDetection
experimental MI:0007 anti tag coimmunoprecipitation in vivo Moncalian,2006 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Moncalian,2006 support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Moncalian,2006 support certain
experimental MI:0114 x-ray crystallography in vitro Moncalian,2006 support certain InteractionDetection FeatureDetection
experimental MI:0506 over expressed level in vivo Moncalian,2006 support certain
experimental MI:0114 x-ray crystallography in vitro Ceregido,2013 support certain InteractionDetection FeatureDetection
experimental MI:0077 nuclear magnetic resonance in vitro Ceregido,2013 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Ceregido,2013 support certain InteractionDetection
experimental MI:0818 molecular weight estimation by coomasie staining Hutchings,2003 support likely ParticipantIdentification
experimental MI:0808 comigration in sds page in vitro Hutchings,2003 support likely InteractionDetection
experimental MI:0089 protein array Hutchings,2003 support likely InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Hutchings,2003 support likely InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9Y5K6) CD2AP_HUMAN PF14604 (SH3_9)
Variant SH3 domain
6 55 100.0/100.0 [mitab][xml]
(Q96B97) SH3K1_HUMAN PF14604 (SH3_9)
Variant SH3 domain
6 54 9.9/9.9 [mitab][xml]
(Q96B97) SH3K1_HUMAN PF14604 (SH3_9)
Variant SH3 domain
105 153 [mitab][xml]
(Q96B97) SH3K1_HUMAN PF14604 (SH3_9)
Variant SH3 domain
274 324 [mitab][xml]

o  Pathways

KEGG: The sequence P06729 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM — the eukaryotic linear motif resource in 2020. (PMID:31680160)

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