ELM - instance LIG_SH3_CIN85_PxpxPR_1 in sequence P06729 at position 327

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI004426	P06729 CD2 CD2_HUMAN	327	332	VHQQKGPPLPRPRVQPKPPH	TP	2J6O 2J7I	Homo sapiens (Human)	351

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0113	western blot	in vitro	Moncalian,2006	support	certain	ParticipantIdentification FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Moncalian,2006	support	certain	InteractionDetection
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Moncalian,2006	support	certain	InteractionDetection
experimental	MI:0096	pull down	in vivo/in vitro	Moncalian,2006	support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Moncalian,2006	support	certain
experimental	MI:0114	x-ray crystallography	in vitro	Moncalian,2006	support	certain	InteractionDetection FeatureDetection
experimental	MI:0506	over expressed level	in vivo	Moncalian,2006	support	certain
experimental	MI:0114	x-ray crystallography	in vitro	Ceregido,2013	support	certain	InteractionDetection FeatureDetection
experimental	MI:0077	nuclear magnetic resonance	in vitro	Ceregido,2013	support	certain	InteractionDetection FeatureDetection
experimental	MI:0065	isothermal titration calorimetry	in vitro	Ceregido,2013	support	certain	InteractionDetection
experimental	MI:0818	molecular weight estimation by coomasie staining		Hutchings,2003	support	likely	ParticipantIdentification
experimental	MI:0808	comigration in sds page	in vitro	Hutchings,2003	support	likely	InteractionDetection
experimental	MI:0089	protein array		Hutchings,2003	support	likely	InteractionDetection
experimental	MI:0096	pull down	in vivo/in vitro	Hutchings,2003	support	likely	InteractionDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(Q9Y5K6) CD2AP_HUMAN	PF14604 (SH3_9) Variant SH3 domain	6	55	100.0/100.0	[mitab][xml]
(Q96B97) SH3K1_HUMAN	PF14604 (SH3_9) Variant SH3 domain	6	54	9.9/9.9	[mitab][xml]
(Q96B97) SH3K1_HUMAN	PF14604 (SH3_9) Variant SH3 domain	105	153		[mitab][xml]
(Q96B97) SH3K1_HUMAN	PF14604 (SH3_9) Variant SH3 domain	274	324		[mitab][xml]

Pathways

KEGG: The sequence P06729 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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