ELM - instance LIG_SH3_2 in sequence Q13444 at position 767

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002435	Q13444 ADAM15 ADA15_HUMAN	767	772	QASALSFPAPPSRPLPPDPV	TP	---	Homo sapiens (Human)	863

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0081	peptide array		Kleino,2009	support	certain	InteractionDetection
experimental	MI:0892	solid phase assay	in vitro	Kleino,2009	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Kleino,2009	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000489:

Alternative splicing removes the SH3-binding motif of Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15), abrogating binding to Proto-oncogene tyrosine-protein kinase Src (SRC). The overexpression of this splice variant has been linked to clinical aggressiveness of breast cancer.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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