The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003687 P29353-2 SHC1
SHC1_HUMAN
317 320 RELFDDPSYVNVQNLDKARQ TP 1JYR  
5CDW  
Homo sapiens (Human) 473

o  Instance evidence

Evidence classPSMI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0113 western blot in vitro Skolnik,1993 support certain ParticipantIdentification FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Skolnik,1993 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Skolnik,1993 support certain InteractionDetection
experimental MI:0968 biosensor Skolnik,1993 support certain InteractionDetection
experimental MI:0065 isothermal titration calorimetry in vitro Papaioannou,2016 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Papaioannou,2016 support certain InteractionDetection FeatureDetection
experimental MI:0077 nuclear magnetic resonance in vitro Nioche,2002 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P62993) GRB2_HUMAN PF00017 (SH2)
SH2 domain
60 135 0.023/0.023 [mitab][xml]
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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