ELM - instance LIG_PTB_Phospho_1 in sequence P24394 at position 491

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001542	P24394 IL4R IL4RA_HUMAN	491	497	TETPLVIAGNPAYRSFSNSL	TP	1IRS	Homo sapiens (Human)	825

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	Nelms,1998	support	certain	FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Nelms,1998	support	certain	InteractionDetection
experimental	MI:0018	two hybrid	in vivo	Nelms,1998	support	certain	InteractionDetection
experimental	MI:0113	western blot	in vitro	Nelms,1998	support	certain	ParticipantIdentification FeatureDetection
experimental	MI:0065	isothermal titration calorimetry	in vitro	Zhou,1996	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Zhou,1996	support	certain	FeatureDetection
experimental	MI:0077	nuclear magnetic resonance	in vitro	Zhou,1996	support	certain	InteractionDetection FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(Q8WU20) FRS2_HUMAN	PF02174 (IRS) PTB domain (IRS-1 type)	17	109		[mitab][xml]
(P35568) IRS1_HUMAN	PF02174 (IRS) PTB domain (IRS-1 type)	160	262		[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

Pathways

KEGG: The sequence P24394 is implicated in the following 8 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement