Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001542 | P24394 IL4R IL4RA_HUMAN |
491 | 497 | TETPLVIAGNPAYRSFSNSL | TP |
1IRS |
Homo sapiens (Human) | 825 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Nelms,1998 | support | certain | FeatureDetection |
experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Nelms,1998 | support | certain | InteractionDetection |
experimental | MI:0018 | two hybrid | in vivo | Nelms,1998 | support | certain | InteractionDetection |
experimental | MI:0113 | western blot | in vitro | Nelms,1998 | support | certain | ParticipantIdentification FeatureDetection |
experimental | MI:0065 | isothermal titration calorimetry | in vitro | Zhou,1996 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Zhou,1996 | support | certain | FeatureDetection |
experimental | MI:0077 | nuclear magnetic resonance | in vitro | Zhou,1996 | support | certain | InteractionDetection FeatureDetection |
Interactions
Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
---|---|---|---|---|---|
(Q8WU20) FRS2_HUMAN | PF02174
(IRS)
PTB domain (IRS-1 type) |
17 | 109 | [mitab][xml] | |
(P35568) IRS1_HUMAN | PF02174
(IRS)
PTB domain (IRS-1 type) |
160 | 262 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000137:
Phosphorylation of Y497 in the PTB-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Insulin receptor substrate 1 (IRS1) protein.
Pathways
KEGG: The sequence P24394 is implicated in the following 8 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement