The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001550 P14784 IL2RB
IL2RB_HUMAN
358 364 NHSLTSCFTNQGYFFFHLPD TP --- Homo sapiens (Human) 551

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Ravichandran,1996 support certain
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Ravichandran,1996 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Ravichandran,1996 support certain FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P29353) SHC1_HUMAN PF00640 (PID)
Phosphotyrosine interaction domain (PTB/PID)
162 318 0.75/0.85 [mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P14784 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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