| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001550 | P14784 IL2RB IL2RB_HUMAN |
358 | 364 | NHSLTSCFTNQGYFFFHLPD | TP | --- | Homo sapiens (Human) | 551 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Ravichandran,1996 | support | certain | |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Ravichandran,1996 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Ravichandran,1996 | support | certain | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P29353) SHC1_HUMAN | PF00640
(PID)
Phosphotyrosine interaction domain (PTB/PID) |
162 | 318 | 0.75/0.85 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000136:
Phosphorylation of Y364 in the PTB-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the SHC-transforming protein 1 (SHC1) protein.
Pathways
- Cytokine cytokine receptor interaction
- Endocytosis
- Human T cell leukemia virus 1 infection
- JAK STAT signaling pathway
- Measles
- PI3K Akt signaling pathway
- Pathways in cancer
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Transcriptional misregulation in cancer
- Viral protein interaction with cytokine and cytokine receptor
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement